Results 101 to 110 of about 11,668 (212)
Neutralization of ricin with polyclonal ricin antibodies.
, 2013 Survival percentage of mice dosed iv (A) or ig (B) with ricin were plotted over 160 h post-intoxication. Goat anti-ricin antibodies were introduced iv either prior-to or post-intoxication at indicated times.
Xiaohua He (361530) +4 more
core +1 more source
The seeds of the Ricinus communis (Castor bean) plant are the source of the economically important commodity castor oil. Castor seeds also contain the proteins ricin and R.
core
, 1997 International audienceRicin is internalized after binding at the cell surface via lectin activity of the B-chain recognizing terminal galactose residues. Ricin-A chain is then translocated to the cytosol from various endocytic structures.
Taupiac, Marie-Pierre +2 more
core +1 more source
International Journal of Medical Microbiology, 2001 The plant toxin ricin binds to terminal galactose-containing cell-surface receptors. The toxin is endocytosed and transported to the Golgi apparatus. Recent evidence suggests that ricin binds to galactosylated calreticulin, which may carry the toxin from the Golgi apparatus to the endoplasmic reticulum (ER).
openaire +2 more sources
How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]
, 2012 A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core
Routing of internalized ricin and ricin conjugates to the Golgi complex.
, 1986 Receptor-mediated endocytosis and intracellular routing of native ricin, and of ricin conjugated to colloidal gold (Ri-Au) and to horseradish peroxidase (Ri-HRP), have been studied in cultured MCF-7 and Vero cells by electron microscopical techniques ...
T I Tønnessen +9 more
core +1 more source
Immunoblot of ricin identified by several anti-ricin antibodies.
, 2013 2 µg of ricin was migrated in 15% SDS-PAGE and blotted onto PVDF membrane. Primary monoclonal antibodies obtained against the A or B chain were incubated for 1 h to bind to ricin.
Laetitia Panigai (350887) +8 more
core +1 more source
Ricin is a toxic protein derived from the castor bean plant (Ricinus communis) and has potential for bioterrorism or criminal use. Therefore, sensitive and rapid analytical methods are needed for its confirmatory detection in environmental samples.
core
In vivo evaluation of each neutralising anti-ricin antibody administered after ricin challenge.
, 2013 (A) Survival curve. CD1 mice were intranasally challenged with 5 LD50 of ricin alone (Δ) or ricin followed by intravenous injection of 5 mg/kg of RB34 antibody (▪), RB37 antibody (•), or RA36 antibody (□) 1 h after ricin challenge. (B) Weight change.
Laetitia Panigai (350887) +8 more
core +1 more source
, 1987 Hybridoma cells which synthesize monoclonal antibodies (mAb) that block ricin toxicity were 50-300-fold resistant to ricin compared with other hybridomas.
COLOMBATTI, Marco, R. J. Youle
core +1 more source