Results 51 to 60 of about 10,488 (210)

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
core   +1 more source

Characterization of MicroRNA and Gene Expression Profiles Following Ricin Intoxication

Toxins, 2019
Ricin, derived from the castor bean plant, is a highly potent toxin, classified as a potential bioterror agent. Current methods for early detection of ricin poisoning are limited in selectivity. MicroRNAs (miRNAs), which are naturally occurring, negative
Nir Pillar, Danielle Haguel, Meitar Grad, Guy Shapira, Liron Yoffe, Noam Shomron   +5 more
doaj   +1 more source

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +1 more source

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source

Two kinds of anti-ricin antibody and ricin interaction evaluated by biosensor based on imaging ellipsometry

, 2011
In order to meet the requirements of antibody comparison and evaluation, the optimization for the surface modification, ligand immobilization, unspecific blocking and ligand receptor interaction condition is introduced to the biosensor based on imaging ...
牛宇, Yan XY, 靳刚, Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China, Zhuang J, 刘丽   +5 more
core   +1 more source

Recommended Immunological Assays to Screen for Ricin-Containing Samples

Toxins, 2015
Ricin, a toxin from the plant Ricinus communis, is one of the most toxic biological agents known. Due to its availability, toxicity, ease of production and absence of curative treatments, ricin has been classified by the Centers for Disease Control and ...
Stéphanie Simon, Sylvia Worbs, Marc-André Avondet, Dobryan M. Tracz, Julie Dano, Lisa Schmidt, Hervé Volland, Brigitte G. Dorner, Cindi R. Corbett   +8 more
doaj   +1 more source

Ricin Poisoning [PDF]

JAMA, 2005
The recent discoveries of ricin, a deadly biologic toxin, at a South Carolina postal facility, a White House mail facility, and a US senator's office has raised concerns among public health officials, physicians, and citizens. Ricin is one of the most potent and lethal substances known, particularly when inhaled.
Jennifer, Audi, Martin, Belson, Manish, Patel, Joshua, Schier, John, Osterloh   +4 more
openaire   +2 more sources

Soil and Genotype Shape the Sugarcane Phytobiome for Enhanced Environmental Adaptation

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Soil type and sugarcane genotype, differing in their adaptability to low‐fertility soils, interact to shape microbial recruitment and host transcriptional responses. In sandy soils, the better‐adapted genotype IACSP‐5503 recruits more plant growth‐promoting bacteria and activates growth‐related genes, while in clayey soils the less‐adapted IACSP‐6007 ...
J. D. Ferreti, B. Ribeiro, J. de A. Bonetti, L. E. A. Camargo, S. Creste, E. E. Kuramae, C. B. Monteiro‐Vitorello   +6 more
wiley   +1 more source

Identification and Biological Evaluation of a Novel Small-Molecule Inhibitor of Ricin Toxin

Molecules
The plant-derived toxin ricin is classified as a type 2 ribosome-inactivating protein (RIP) and currently lacks effective clinical antidotes. The toxicity of ricin is mainly due to its ricin toxin A chain (RTA), which has become an important target for ...
Xinran Yang, Aili Wei, Xiyuan Cao, Zicheng Wang, Hongzhi Wan, Bo Wang, Hui Peng   +6 more
doaj   +1 more source

Targeting ricin to the ribosome [PDF]

Toxicon, 2013
The plant toxin ricin is highly toxic for mammalian cells and is of concern for bioterrorism. Ricin belongs to a family of functionally related toxins, collectively referred to as ribosome inactivating proteins (RIPs), which disable ribosomes and halt protein synthesis. Currently there are no specific antidotes against ricin or related RIPs.
Kerrie L, May, Qing, Yan, Nilgun E, Tumer   +2 more
openaire   +2 more sources