Results 61 to 70 of about 232 (115)

Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin

Toxins, 2018
Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach, Anita Sapoznikov, Ron Alcalay, Moshe Aftalion, Sharon Ehrlich, Arik Makovitzki, Avi Agami, Avishai Mimran, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +11 more
doaj   +1 more source

Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin

Scientific Reports
The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity.
Stefanie Lietz, Lena-Marie Sokolowski, Holger Barth, Katharina Ernst   +3 more
doaj   +1 more source

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors

Toxins
The life-threatening disease pertussis, also known as whooping cough, is caused by a complex interplay of several virulence factors produced by the bacterium Bordetella (B.) pertussis.
Stefanie Lietz, Holger Barth
doaj   +1 more source

Studies on the mode of action of bacterial AB5 toxins

Nippon Saikingaku Zasshi, 2013
Bacterial AB5 toxins are proteins, produced by pathogenic bacteria including of Vibrio cholerae, Shigella dysenteriae, and enterohaemorrhagic Escherichia coli, which are usually released into the extracellular medium and cause disease by killing or altering the metabolism of target eukaryotic cells.
openaire   +3 more sources

Characterization of Rabbit Polyclonal Sera against Recombinant Shiga Toxin and its Subunits for Detection of Stx-Producing E. coli

Iranian Journal of Allergy, Asthma and Immunology, 2011
Shiga toxin (Stx) is the principal virulence factor of Shigatoxigenic Escherichia coli (STEC), a food-born pathogen associated disease with uncomplicated diarrhea or the hemolytic-uremic syndrome.
Mana Oloomi, Saeid Bouzari
doaj  

Structure and function of a fungal AB toxin-like chimerolectin involved in anti-nematode defense

The EMBO Journal
ABSTRACT Fungal defense against predators largely relies on protein toxins, many of which are lectins. We previously showed that the production of the nematotoxin CCTX2 is upregulated in the Agaricomycete Coprinopsis cinerea upon predation by nematodes.
Stefanie S Schmieder, Gabriele Cordara, Flore Kersten, Kevin Steiner, Clara H Samim, David F Plaza, Ahmad Ali-Ahmad, Andreas Boeggild, Jesper L Karlsen, Blanka O Sokolowska, Thomas Boesen, Ute Krengel, Markus Künzler   +12 more
openaire   +1 more source

AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida , has tropism for myeloid cells

Frontiers in Immunology
Abstract The AB-type toxin AIP56 is a key virulence factor of Photobacterium damselae subsp. piscicida ( Phdp ), inducing apoptosis in fish immune cells.
Inês Lua Freitas, Inês Lua Freitas, Inês Lua Freitas, Maria Fátima Macedo, Maria Fátima Macedo, Liliana Oliveira, Liliana Oliveira, Pedro Oliveira, Ana do Vale, Ana do Vale, Nuno M.S. dos Santos, Nuno M.S. dos Santos   +11 more
openaire   +4 more sources

Deciphering the Emergence of Biofilm-Independent Colistin Persistence and Resistance in A. baumannii: Toxin–Antitoxin Omics and Novel T/A mRNA-asRNA Balance Regulatory Models

Antibiotics
Background: Persistence represents a critical evolutionary reservoir for the development of antimicrobial resistance in Acinetobacter baumannii (Ab). Understanding the basal mechanisms that enable this survival strategy is crucial for elucidating how ...
Eleonora Chines, Ludovica Boscarelli, Gaia Vertillo Aluisio, Maria Santagati, Maria Lina Mezzatesta, Viviana Cafiso   +5 more
doaj   +1 more source

Identification and characterization of novel inhibitors of bacterial AB-type toxins

AB-type toxins are extremely potent bacterial virulence factors and in many cases, the causative agents of severe disease. Their detrimental effects on the host and importance during the infection process make bacterial AB-type toxins a promising therapeutic target.
openaire   +1 more source

Theab initiostructure and refinement of a scorpion protein toxin [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
G. D. Smith, R. H. Blessing, S. E. Ealick, J. C. Fontecilla-Camps, H. A. Hauptman, D. Housset, D. A. Langs, R. Miller   +7 more
openaire   +1 more source