The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network [PDF]
, 2008 The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion ...
Amessou, M +37 more
core +1 more source
Cell-Free Systems Enable the Production of AB5 Toxins for Diagnostic Applications
Toxins, 2022 Cell-free protein synthesis (CFPS) represents a versatile key technology for the production of toxic proteins. As a cell lysate, rather than viable cells, is used, the toxic effects on the host organism can be circumvented. The open nature of cell-free systems allows for the addition of supplements affecting protein concentration and folding.
Franziska Ramm +5 more
openaire +3 more sources
How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]
, 2012 A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core
Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops [PDF]
, 2002 Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and humans. Natural and experimental infection of calves with STEC may result in acute enteritis or subclinical infection ...
Campbell, June +23 more
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Botulinum toxin a in the treatment of blepharospasm - A 10-year experience [PDF]
, 2005 To evaluate the long-term effect of botulinum toxin type A (BTX) in the treatment of blepharospasm, a retrospective analysis was conducted from the patients seen at the Movement Disorders Clinic of the Department of Neurology, Hospital das Clinicas ...
Goncalves, LR +7 more
core +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J. +7 more
core +1 more source
EFFECT OF AFLATOXINS ON GOATS MILK PRODUCTION AND ITS CHEMICAL AND PHYSICAL COMPOSITION [PDF]
Mesopotamia Journal of Agriculture, 2008 This study was conducted to show the effects of each aflatoxins (AF) or activated sodum bentonite(AB) .Singly or combination in the following groups:1- animals fed Diet (AF) alone at 2.5mg/kg.2-animal fed died (AF)at 2.5mg/kgwith AB(5g/kg).
doaj +1 more source
Modulation of toxin stability by 4-phenylbutyric acid and negatively charged phospholipids. [PDF]
PLoS ONE, 2011 AB toxins such as ricin and cholera toxin (CT) consist of an enzymatic A domain and a receptor-binding B domain. After endocytosis of the surface-bound toxin, both ricin and CT are transported by vesicle carriers to the endoplasmic reticulum (ER).
Supriyo Ray +4 more
doaj +1 more source
Biomedical Community and the Biological and Toxin Weapons Convention [PDF]
, 2001 YesNegotiations to find a legally binding way to strengthen the Biological and Toxin Weapons Convention (BTWC) of 1972 [1]are in danger of failing. The crisis was precipitated during the current round of talks, now in its final week in Geneva, when the
Whitby, Simon M., Dando, Malcolm
core +4 more sources
, 2021 Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.
Taruna Anand (828898) +4 more
core +1 more source