Results 91 to 100 of about 817,572 (203)
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Shiga toxin (STx) belongs to the AB(5) toxin family and is transiently localized in the periplasm before secretion into the extracellular milieu. While producing outer membrane vesicles (OMVs) containing only A subunit of the toxin (STxA), we created specific STx1B- and STx2B-deficient mutants of E. coli O157:H7.
Kim, SH Kim, Sang-Hyun +11 more
openaire +3 more sources
Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study [PDF]
, 2009 Aim: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. Methods: Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport (R)). The primary endpoint was reduction in
Toelle, Thomas +13 more
core +1 more source
Structural investigation of the Yersinia pseudotuberculosis AB-toxin CNFy
, 2015 Yersinia cytotoxic necrotizing factor (CNFy) is a recently discovered AB-toxin essential for the invasion process of Yersinia. Due to its ability to deamidate and thereby constitutively activate small Rho-GTPases CNFy was combined with CNF1 to CNF3 of E.
openaire +1 more source
BiP Negatively Affects Ricin Transport
Toxins, 2013 The AB plant toxin ricin binds both glycoproteins and glycolipids at the cell surface via its B subunit. After binding, ricin is endocytosed and then transported retrogradely through the Golgi to the endoplasmic reticulum (ER).
Kirsten Sandvig +4 more
doaj +1 more source
The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]
, 1989 The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
M. Gratzl +10 more
core +1 more source
Cell Reports, 2013 Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but also ...
Laurence Abrami +6 more
doaj +1 more source
Prevalence and genetic characterization of shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh [PDF]
, 2008 To determine the prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) in slaughter animals in Dhaka, Bangladesh, we collected rectal contents immediately after animals were slaughtered.
Beumer, R.R. +7 more
core +1 more source
Toxins, 2015 Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be performed.
T. Scott Devera +4 more
doaj +1 more source
PLoS ONE, 2011 Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin.
Michael Taylor +8 more
doaj +1 more source
Botulinum Toxin A for the Treatment of Keloids [PDF]
, 2012 Introduction: Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity.
Bureik, D. +11 more
core +1 more source