Results 71 to 80 of about 817,572 (203)

Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation [PDF]

, 2009
Single-domain antibody fragments (VHHs) have several beneficial properties as compared to conventional antibody fragments. However, their small size complicates their toxin- and virus-neutralizing capacity.
Fijten, H.P.D., Smits, C.B., H. P. D. Fijten, C. B. van Solt, Harmsen, M.M., M. M. Harmsen   +5 more
core   +1 more source

Novel Strategies to Inhibit Pertussis Toxin

Toxins, 2022
Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT).
Katharina Ernst
doaj   +1 more source

The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors [PDF]

Nature Communications, 2014
Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology are poorly understood.
Spaan, András N., Vrieling, Manouk, Wallet, Pierre, Badiou, Cédric, Reyes-Robles, Tamara, Ohneck, Elizabeth A., Benito, Yvonne, Haas, Carla J. C., Day, Christopher J., Jennings, Michael P., Lina, Gérard, Vandenesch, François, Kessel, Kok P. M., Torres, Victor J., Strijp, Jos A. G., Henry, Thomas   +15 more
openaire   +4 more sources

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
core   +1 more source

Role of Fc in Antibody-Mediated Protection from Ricin Toxin

Toxins, 2014
We have studied the role of the antibody (Ab) Fc region in mediating protection from ricin toxicity. We compared the in vitro and in vivo effects of intact Ig and of Fab fragments derived from two different neutralizing Ab preparations, one monoclonal ...
Seth. H. Pincus, Anushka Das, Kejing Song, Grace A. Maresh, Miriam Corti, Jody Berry   +5 more
doaj   +1 more source

Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. [PDF]

PLoS ONE, 2013
We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization.
Yoshiko Fukuyama, Daisuke Tokuhara, Shinichi Sekine, Kazuyoshi Aso, Kosuke Kataoka, Julia Davydova, Masato Yamamoto, Rebekah S Gilbert, Yuka Tokuhara, Keiko Fujihashi, Jun Kunisawa, Yoshikazu Yuki, Hiroshi Kiyono, Jerry R McGhee, Kohtaro Fujihashi   +14 more
doaj   +1 more source

The Chaperonin TRiC/CCT Inhibitor HSF1A Protects Cells from Intoxication with Pertussis Toxin

Toxins
Pertussis toxin (PT) is a bacterial AB5-toxin produced by Bordetella pertussis and a major molecular determinant of pertussis, also known as whooping cough, a highly contagious respiratory disease.
Jinfang Jia, Manuel Zoeschg, Holger Barth, Arto T. Pulliainen, Katharina Ernst   +4 more
doaj   +1 more source

Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin [PDF]

, 1992
Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy
Stecher, Brigitte, Weller, U., De Graan, P., Gratzl, Manfred, Graan, P.N.E. de, Gratz, M., Hens, Jacques J.H., Stecher, B., Gispen, W. H., De Graan, Pierre N.E., Hens, J.J.H., Hens, J., Jacques J.H. Hens, Ulrich Weller, Willem-Hendrik Gispen, Pierre N.E. De Graan, Manfred Gratzl, Gispen, Willem-Hendrik, Gispen, W.H., Weller, Ulrich, Brigitte Stecher   +20 more
core   +2 more sources

Laboratory diagnostic methods for clostridioides difficile infection

One Health & Risk Management, 2023
Introduction. Clostridioides difficile is an anaerobic gram-positive, sporeforming, toxin-producing bacillus that is transmitted among humans through the fecal-oral route, as a result of ingestion of spores. Colonization of C.
Anastasia ALEXANDROV
doaj  

High Affinity Binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM Adhesion Glycoprotein

Toxins, 2017
The protein toxin Cytotoxic Necrotizing Factor 1 (CNF1) is a major virulence factor of pathogenic Escherichia coli strains. It belongs to a family of single chain AB-toxins, which enter mammalian cells by receptor-mediated endocytosis.
Franziska Reppin, Sylvie Cochet, Wassim El Nemer, Günter Fritz, Gudula Schmidt   +4 more
doaj   +1 more source