Results 71 to 80 of about 232 (115)

Structural investigations of a novel bacterial AB₅toxin [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2011
Nours J. Le, L. Tan, S. Troy, E. Byres, D. Smith, A. W. Paton, J. C. Paton, J. Rossjohn, T. Beddoe   +8 more
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Identification and characterization of human endogenous proteins and peptides as novel inhibitors for the Bordetella pertussis toxin and related AB-type protein toxins

Pertussis also called whooping cough is a highly infectious respiratory disease caused by an infection with Bordetella (B.) pertussis. The secreted virulence factor pertussis toxin (PT) is an AB-type protein toxin and associated with the symptoms and the life-threatening complications of severe pertussis, especially in human infants.
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Impact of Clostridium botulinum C2 Toxin on the ultrastructure of cells [PDF]

BIO Web of Conferences
Bellemann Jasmin Christine, Borho Joscha, Read Clarissa, Walther Paul, Barth Holger   +4 more
doaj   +1 more source

A double-edged sword: AB toxins as attack (cholera toxin) and defense (CCTX2) mechanisms

AB toxins are proteins often used by pathogens as an attack molecule. However, some organisms use them as a defense molecule, when threatened by a predator. This PhD thesis provides insights on the understanding of the molecular mechanism of two AB toxins, representing the two distinct roles of attack and defense.
openaire   +2 more sources

Investigation of Clostridium difficile antigen, toxin A+B and toxin genes in cases of hospital acquired diarrhea

International Journal of Infectious Diseases, 2014
S. Kescioglu, O. Coskun, O. Bedir, A. Karakas, C. Artuk, C.P. Eyigun   +5 more
doaj   +1 more source

Biotechnological application of AIP56, an AB-toxin from Photobacterium damselae subsp. piscicida

, 2021
openaire   +2 more sources

Novel endogenous protein-based strategies to inhibit clinically relevant bacterial AB-type toxins including pertussis toxin

Archives of Toxicology
Stefanie Lietz, Holger Barth
openaire   +1 more source

Intracellular trafficking of AIP56, a bacterial AB toxin trageting NF - кB

, 2015
openaire   +2 more sources

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Bacterial AB toxins and host–microbe interactions

2022
AB toxins are protein virulence factors secreted by many bacterial pathogens, contributing to the pathogenicity of the cognate bacteria. AB toxins consist of two functionally distinct components: the enzymatic "A" component for pathogenicity and the receptor-binding "B" component for toxin delivery.
openaire   +2 more sources

Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics.

Journal of molecular medicine (Berlin, Germany), 2014
Bacterial AB5 toxins are a clinically relevant class of exotoxins that include several well-known members such as Shiga, cholera, and pertussis toxins. Infections with toxin-producing bacteria cause devastating human diseases that affect millions of individuals each year and have no definitive medical treatment.
Somshuvra, Mukhopadhyay, Adam D, Linstedt   +1 more
openaire   +2 more sources