The Ins and Outs of Anthrax Toxin [PDF]
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Gisou Van Der Goot +2 more
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Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation [PDF]
Toxins, 2016 Interaction between bacterial toxins and cellular surface receptors is an important component of the host-pathogen interaction. Anthrax toxin protective antigen (PA) binds to the cell surface receptor, enters the cell through receptor-mediated ...
Jianjun Sun, Pedro Jacquez
doaj +5 more sources
Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism [PDF]
Scientific Reports, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Alexandra J. Machen +2 more
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Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics [PDF]
Toxins, 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang +3 more
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Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas [PDF]
Toxins, 2020 Canine oral mucosal melanomas (OMM) are the most common oral malignancy in dogs and few treatments are available. Thus, new treatment modalities are needed for this disease.
Adriana Tomoko Nishiya +13 more
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Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin [PDF]
iScience, 2022 Summary: The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis.
Matthias Przyklenk +8 more
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Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage [PDF]
ToxinsAnthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax.
Lihong Wu +10 more
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Tumor Targeting and Drug Delivery by Anthrax Toxin [PDF]
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
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Anthrax toxin component, Protective Antigen, protects insects from bacterial infections. [PDF]
PLoS Pathogens, 2020 Anthrax is a major zoonotic disease of wildlife, and in places like West Africa, it can be caused by Bacillus anthracis in arid nonsylvatic savannahs, and by B. cereus biovar anthracis (Bcbva) in sylvatic rainforests.
Saleem Alameh +11 more
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Pathogens, 2022 Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876―when Robert Koch demonstrated that Bacillus anthracis caused anthrax―it has been ...
William A. Bower +6 more
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