The Ins and Outs of Anthrax Toxin [PDF]
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
F Gisou Van Der Goot, Jérôme Bürgi
exaly +4 more sources
Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation [PDF]
Toxins, 2016 Interaction between bacterial toxins and cellular surface receptors is an important component of the host-pathogen interaction. Anthrax toxin protective antigen (PA) binds to the cell surface receptor, enters the cell through receptor-mediated ...
Jianjun Sun, Pedro Jacquez
doaj +5 more sources
Anthrax Toxin: A Pioneer of Targeted Protein Toxins [PDF]
ToxinsWith anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells.
Sandy Richter, Gudula Schmidt
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Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism [PDF]
Scientific Reports, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Alexandra J. Machen +2 more
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Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics [PDF]
Toxins, 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang +3 more
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Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas [PDF]
Toxins, 2020 Canine oral mucosal melanomas (OMM) are the most common oral malignancy in dogs and few treatments are available. Thus, new treatment modalities are needed for this disease.
Adriana Tomoko Nishiya +13 more
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Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin [PDF]
iScience, 2022 Summary: The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis.
Matthias Przyklenk +8 more
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Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage [PDF]
ToxinsAnthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax.
Lihong Wu +10 more
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Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins [PDF]
Journal of Biological Chemistry, 2014 Anthrax spores can be aerosolized and dispersed as a bioweapon. Current postexposure treatments are inadequate at later stages of infection, when high levels of anthrax toxins are present. Anthrax toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2).
Shan Chen, Diana Diaz-Arevalo
exaly +3 more sources
Anthrax Toxin Characterization [PDF]
Acta Medica, 2002 The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled.
Jiří Patočka, Miroslav Špliňo
doaj +3 more sources