The Ins and Outs of Anthrax Toxin [PDF]
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Françoise Gisou van der Goot +2 more
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Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics. [PDF]
Toxins (Basel), 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Ouyang W, Xie T, Fang H, Frucht DM.
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Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas. [PDF]
Toxins (Basel), 2020 Canine oral mucosal melanomas (OMM) are the most common oral malignancy in dogs and few treatments are available. Thus, new treatment modalities are needed for this disease.
Nishiya AT +13 more
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Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin. [PDF]
iScience, 2022 Summary: The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis.
Przyklenk M +8 more
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Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage. [PDF]
Toxins (Basel)Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax.
Wu L +10 more
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Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation. [PDF]
Toxins (Basel), 2016 Interaction between bacterial toxins and cellular surface receptors is an important component of the host-pathogen interaction. Anthrax toxin protective antigen (PA) binds to the cell surface receptor, enters the cell through receptor-mediated ...
Sun J, Jacquez P.
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Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism. [PDF]
Sci Rep, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Machen AJ, Fisher MT, Freudenthal BD.
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Anthrax toxin component, Protective Antigen, protects insects from bacterial infections. [PDF]
PLoS Pathog, 2020 Anthrax is a major zoonotic disease of wildlife, and in places like West Africa, it can be caused by Bacillus anthracis in arid nonsylvatic savannahs, and by B. cereus biovar anthracis (Bcbva) in sylvatic rainforests.
Alameh S +11 more
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Cytoskeleton as an Emerging Target of Anthrax Toxins
Toxins, 2012 Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET).
Jean-Nicolas Tournier, Yannick Trescos
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Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system.
MBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Stephen H. Leppla +2 more
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