Results 41 to 50 of about 19,232 (195)

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]

PLoS Pathogens, 2007
Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery, Nicholas S Duesbery   +8 more
doaj   +1 more source

Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin [PDF]

, 2012
The successful use of Bacillus anthracis as a lethal biological weapon has prompted renewed research interest in the development of more effective vaccines against anthrax.
Roehrl, Michael H, Wang, Jun-Xia
core   +1 more source

Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis.

PLoS Neglected Tropical Diseases, 2019
Bacillus anthracis and Yersinia pestis are zoonotic bacteria capable of causing severe and sometimes fatal infections in animals and humans. Although considered as diseases of antiquity in industrialized countries due to animal and public health ...
Theresa B Gallagher, Gabriela Mellado-Sanchez, Ana L Jorgensen, Stephen Moore, James P Nataro, Marcela F Pasetti, Les W Baillie   +6 more
doaj   +1 more source

Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets. [PDF]

, 2019
The ability of antibodies to bind a wide variety of analytes with high specificity and high affinity makes them ideal candidates for therapeutic and diagnostic applications. However, the poor stability and high production cost of antibodies have prompted
Abate, Adam R, Cardiel, Joshua, Chen, Chun-Long, Chen, Yulin, Connolly, Michael D, Dehigaspitiya, Dilani C, Grzincic, Elissa M, Jian, Tengyue, Karbaschi, Mohsen, Kim, Jae Hong, Kim, Samuel C, Kirshenbaum, Kent, Kline, Mark A, Liu, Jianfang, Murray, Daniel J, Ren, Gang, Tresca, Blakely W, Udumula, Venkatareddy, Yun, Lisa, Zuckermann, Ronald N   +19 more
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A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis

Scientific Reports, 2018
Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder, Shreya Das, Vikas Somani, Shivakiran S. Makam, Kingston J. Joseph, Rakesh Bhatnagar   +5 more
doaj   +1 more source

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

Frontiers in Cellular and Infection Microbiology, 2018
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu, Syed R. Ali, Ethan Bier, Victor Nizet, Victor Nizet   +4 more
doaj   +1 more source

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. [PDF]

PLoS ONE, 2011
Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells.
Angelika Kronhardt, Monica Rolando, Christoph Beitzinger, Caroline Stefani, Michael Leuber, Gilles Flatau, Michel R Popoff, Roland Benz, Emmanuel Lemichez   +8 more
doaj   +1 more source

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

Toxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse, Xizhong Cui, Yan Li, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker   +5 more
doaj   +1 more source

Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri, Jason F, Wiggins, Robin E, Lindeman, Stephen H, Leppla   +3 more
openaire   +2 more sources

A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015 [PDF]

, 2018
Background People who inject drugs (PWID) are at an increased risk of wound botulism, a potentially fatal acute paralytic illness. During the first 6 months of 2015, a large outbreak of wound botulism was confirmed among PWID in Scotland, which resulted ...
Amanda Weir, Andrew McAuley, CC McGuigan, CN Ramsay, Corinne Amar, D Akbulut, DJ Passaro, E MacDonald, E Tweed, European Centre for Disease Prevention and Control, Gauri Godbole, Gillian Penrice, GY Chang, Health Protection Scotland, Information Services Division (ISD), J McLauchlin, J Sobel, J Strang, JA Jones, JA Stoltz, K Alpers, K Dunleavy, Kathie Grant, Kirsten M. A. Trayner, Kirsty Roy, M Desai, M Harris, M Ragonnet-Cronin, M Schroeter, MG Booth, N Markwick, National Records of Scotland, NE Palmateer, Public Health England, Health Protection Scotland, Public Health Wales, and Public Health Agency Northern Ireland, RJ Gordon, SB Werner, Scottish Government, Scottish Health Protection Network, SJ Hahné, SR Offerman, TN Wenham, VD Hope, VD Hope, Y Soukup-Baljak   +43 more
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