Results 41 to 50 of about 8,844 (171)

c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

Microbiology Spectrum
The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu, Junmin Yao, Chengfeng Lei, Xiulian Sun   +3 more
doaj   +1 more source

Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection. [PDF]

PLoS ONE, 2015
Protective antigen (PA), one of the components of the anthrax toxin, is the major component of human anthrax vaccine (Biothrax). Human anthrax vaccines approved in the United States and Europe consist of an alum-adsorbed or precipitated (respectively ...
Matthew D Reed, Julie A Wilder, William M Mega, Julie A Hutt, Philip J Kuehl, Michelle W Valderas, Lawrence L Chew, Bertrand C Liang, Charles H Squires   +8 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Membrane translocation by anthrax toxin [PDF]

Molecular Aspects of Medicine, 2009
Much attention has been focused on anthrax toxin recently, both because of its central role in the pathogenesis of Bacillus anthracis and because it has proven to be one of the most tractable toxins for studying how enzymic moieties of intracellularly acting toxins traverse membranes.
openaire   +2 more sources

Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri, Jason F, Wiggins, Robin E, Lindeman, Stephen H, Leppla   +3 more
openaire   +2 more sources

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Carrion ecology: concepts, interdisciplinary synthesis, and perspectives

Biological Reviews, EarlyView.
ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón, José A. Sánchez‐Zapata, Travis L. DeVault, Wayne M. Getz, Zebensui Morales‐Reyes, Daniel Redondo‐Gómez, Lara Naves‐Alegre, Solange A. Batista‐Nunes, Esther Sebastián‐González, Juan M. Pérez‐García, Kelly A. Waters, Thijs van Overveld, Craig Smith, Nuria Selva, Thomas A. Schlacher, Graeme Ruxton, Jesús Rodríguez, Martina‐M. Quaggiotto, Paula L. Perrig, Norman Owen‐Smith, Thomas M. Newsome, Isabel Navas, Yoshihiro Nakashima, Ana Mateos, Carlos Martínez‐Carrasco, Daniel Martín‐Vega, Berta Martín‐López, Antoni Margalida, Sergio A. Lambertucci, Adam Kane, Kevin Healy, Akane Hashizume, Antonio J. García‐Fernández, José A. Donázar, M. Eric Benbow, James C. Beasley, Philip S. Barton, Kathleen A. Alexander, Eneko Arrondo   +38 more
wiley   +1 more source

Role of the Antigen Capture Pathway in the Induction of a Neutralizing Antibody Response to Anthrax Protective Antigen

mBio, 2018
Toxin neutralizing antibodies represent the major mode of protective immunity against a number of toxin-mediated bacterial diseases, including anthrax; however, the cellular mechanisms that lead to optimal neutralizing antibody responses remain ill ...
Anita Verma, Miriam M. Ngundi, Gregory A. Price, Kazuyo Takeda, James Yu, Drusilla L. Burns   +5 more
doaj   +1 more source

The Intriguing History of Gloves and Their Application to Surgery

ANZ Journal of Surgery, EarlyView.
Gloves were first worn to protect against cold and injury. In surgery, their purpose now is to reduce surgical site infection and blood‐borne transmission of disease. Surprisingly, their adoption in surgery as a routine has been remarkably recent and had a bizarre origin.
Spencer W. Beasley
wiley   +1 more source

A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]

PLoS Pathogens, 2007
The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani, Diane Thomas, Kelly A Dryden, Vijay Reddy, Marc E Siladi, John M Marlett, G Jonah A Rainey, Michael E Pique, Heather M Scobie, Mark Yeager, John A T Young, Marianne Manchester, Anette Schneemann   +12 more
doaj   +1 more source