Results 41 to 50 of about 142,050 (194)
Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis [PDF]
PeerJ, 2019 The anthrax toxin is a virulence factor produced by the bacterium Bacillus anthracis. Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of B.
Kochi Toyomane +3 more
doaj +2 more sources
Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin [PDF]
, 2010 Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core +1 more source
PLoS Neglected Tropical Diseases, 2019 Bacillus anthracis and Yersinia pestis are zoonotic bacteria capable of causing severe and sometimes fatal infections in animals and humans. Although considered as diseases of antiquity in industrialized countries due to animal and public health ...
Theresa B Gallagher +6 more
doaj +1 more source
Innate Immune Interactions between Bacillus anthracis and Host Neutrophils
Frontiers in Cellular and Infection Microbiology, 2018 Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu +4 more
doaj +1 more source
Toxins, 2021 Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse +5 more
doaj +1 more source
Scientific Reports, 2018 Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder +5 more
doaj +1 more source
Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. [PDF]
PLoS ONE, 2011 Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells.
Angelika Kronhardt +8 more
doaj +1 more source
Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]
, 2009 The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core +1 more source
Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells [PDF]
Molecular Microbiology, 2006 Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by a third factor, protective antigen (PA), which binds ...
Francisco J, Maldonado-Arocho +3 more
openaire +2 more sources
Microbiology SpectrumThe Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu +3 more
doaj +1 more source