Results 61 to 70 of about 142,050 (194)
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino +2 more
wiley +1 more source
Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri +3 more
openaire +2 more sources
Pathogens, 2022 Bacillus cereus group bacteria containing the anthrax toxin genes can cause fatal anthrax pneumonia in welders. Two welder’s anthrax cases identified in 2020 were investigated to determine the source of each patient’s exposure. Environmental sampling was
Patrick Dawson +33 more
doaj +1 more source
Changing the Receptor Specificity of Anthrax Toxin [PDF]
mBio, 2012 ABSTRACT The actions of many bacterial toxins depend on their ability to bind to one or more cell-surface receptors. Anthrax toxin acts by a sequence of events that begins when the protective-antigen (PA) moiety of the toxin binds to either one of two cell-surface proteins, ANTXR1 and ANTXR2, and is proteolytically activated. The
Mechaly, Adva +2 more
openaire +5 more sources
The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. [PDF]
PLoS ONE, 2015 Anthrax toxin receptors act as molecular clamps or switches that control anthrax toxin entry, pH-dependent pore formation, and translocation of enzymatic moieties across the endosomal membranes.
Pedro Jacquez +12 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 31, 21 August 2026.Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco +7 more
wiley +1 more source
Requirements for anthrax toxin entry into cells [PDF]
, 2010 Bacillus anthracis secretes a harmful exotoxin called anthrax toxin. Anthrax toxin has deleterious effects on several host cell types and is a significant contributor to anthrax pathogenesis. Toxin-deleted strains of B.
Ryan, Patricia Lynn
core
mSphere, 2020 Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have complicated the ...
Fabiana Freire Mendes de Oliveira +7 more
doaj +1 more source
Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Advanced Science, Volume 13, Issue 46, 17 August 2026.Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li +9 more
wiley +1 more source
Quantitative Assay for Crude Anthrax Toxins [PDF]
Journal of Bacteriology, 1965 Haines, Bertram W. (U.S. Army Biological Laboratories, Frederick, Md.), Frederick Klein, and Ralph E. Lincoln . Quantitative assay for crude anthrax toxins. J. Bacteriol. 89: 74–83.
B W, HAINES, F, KLEIN, R E, LINCOLN
openaire +2 more sources