Results 51 to 60 of about 10,314 (165)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin

, 2010
Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly [PDF]

, 2004
A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non ...
Jiang, I., Kang, A.S., Morrow, P.R., Sawada-Hirai, R., Ruther, P., Wang, F., Sun, S.M., Nedellec, R.   +7 more
core  

Decoding Biothreats With FT‐ICR‐MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Genome sequencing is the gold standard for microbial identification. However, it fails to distinguish closely related species with overlapping genetic features. This is the case of Bacillus cereus and Bacillus cytotoxicus, two members of the B. cereus group with distinct pathogenic profiles. While B. cereus, a well‐known opportunistic pathogen
Maria Inês Romão, Inês Gomes, Wilson Antunes, Petr Novak, Marta Sousa Silva, Carlos Cordeiro   +5 more
wiley   +1 more source

Role of the Antigen Capture Pathway in the Induction of a Neutralizing Antibody Response to Anthrax Protective Antigen

mBio, 2018
Toxin neutralizing antibodies represent the major mode of protective immunity against a number of toxin-mediated bacterial diseases, including anthrax; however, the cellular mechanisms that lead to optimal neutralizing antibody responses remain ill ...
Anita Verma, Miriam M. Ngundi, Gregory A. Price, Kazuyo Takeda, James Yu, Drusilla L. Burns   +5 more
doaj   +1 more source

A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]

PLoS Pathogens, 2007
The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani, Diane Thomas, Kelly A Dryden, Vijay Reddy, Marc E Siladi, John M Marlett, G Jonah A Rainey, Michael E Pique, Heather M Scobie, Mark Yeager, John A T Young, Marianne Manchester, Anette Schneemann   +12 more
doaj   +1 more source

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source

A Pilot Metagenomic Study Demonstrating Virtual Reality Head Mounted Displays Utilized in Medical Education Are Reservoirs of Viable Pathogenic Microbes

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Metagenomic analysis identified 27 pathogenic bacteria including 4 "ESKAPE" pathogens (Enterobacter sp., Staphylococcus aureus, Klebsiella spp., and Escherichia coli) and numerous organisms associated with ocular infections. A broad range of antimicrobial resistance genes were identified conveying resistance to Methicillin, Aminoglycosides, Macrolides,
Adrian Goldsworthy, Matthew Olsen, Mohd Fairuz Shiratuddin, Simon McKirdy, Rashed Alghafri, Abiola Senok, Hamda Alfalasi, Kok Wai Wong, Lotti Tajouri   +8 more
wiley   +1 more source

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406), Norais Nathalie, Jeffrey T. Rubino (490079), Norais, Nathalie, Leuzzi, Rosanna, Massimiliano Biagini, Biagini Massimiliano, Martinelli Manuele, Scarselli, Maria, Jeffrey T Rubino, Serruto Davide, Manuele Martinelli, Rosanna Leuzzi (490078), Nathalie Norais, Davide Serruto, Rosanna Leuzzi, Rubino, Jeffrey T., Nathalie Norais (159651), Serruto, Davide, Unnikrishnan, Meera, Manuele Martinelli (272421), Cantini Francesca, Francesca Cantini, Maria Scarselli, Martinelli, Manuele, Cantini, Francesca, Biagini, Massimiliano, Meera Unnikrishnan, Rubino Jeffrey T., Valeria Cafardi (490077), Massimiliano Biagini (247421), Unnikrishnan Meera, Cafardi, Valeria, Leuzzi Rosanna, Cafardi Valeria, Valeria Cafardi, Meera Unnikrishnan (183268), Scarselli Maria, Francesca Cantini (208272), Davide Serruto (148434)   +39 more
core   +1 more source