Results 51 to 60 of about 8,844 (171)

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Quantitative Assay for Crude Anthrax Toxins [PDF]

Journal of Bacteriology, 1965
Haines, Bertram W. (U.S. Army Biological Laboratories, Frederick, Md.), Frederick Klein, and Ralph E. Lincoln . Quantitative assay for crude anthrax toxins. J. Bacteriol. 89: 74–83.
B W, HAINES, F, KLEIN, R E, LINCOLN
openaire   +2 more sources

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Epidemiologic Investigation of Two Welder’s Anthrax Cases Caused by Bacillus cereus Group Bacteria: Occupational Link Established by Environmental Detection

Pathogens, 2022
Bacillus cereus group bacteria containing the anthrax toxin genes can cause fatal anthrax pneumonia in welders. Two welder’s anthrax cases identified in 2020 were investigated to determine the source of each patient’s exposure. Environmental sampling was
Patrick Dawson, Johanna S. Salzer, Caroline A. Schrodt, Karl Feldmann, Cari B. Kolton, Jay E. Gee, Chung K. Marston, Christopher A. Gulvik, Mindy G. Elrod, Aaron Villarma, Rita M. Traxler, María E. Negrón, Kate A. Hendricks, Heather Moulton-Meissner, Laura J. Rose, Paul Byers, Kathryn Taylor, Daphne Ware, Gary A. Balsamo, Theresa Sokol, Bret Barrett, Erica Payne, Saad Zaheer, Ga On Jung, Stephen Long, Ricardo Quijano, Lindsey LeBouf, Briana O’Sullivan, Erin Swaney, James M. Antonini, Marie A. de Perio, Zachary Weiner, William A. Bower, Alex R. Hoffmaster   +33 more
doaj   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. [PDF]

PLoS ONE, 2015
Anthrax toxin receptors act as molecular clamps or switches that control anthrax toxin entry, pH-dependent pore formation, and translocation of enzymatic moieties across the endosomal membranes.
Pedro Jacquez, Gustavo Avila, Kyle Boone, Agamyrat Altiyev, Jens Puschhof, Roland Sauter, Emma Arigi, Blanca Ruiz, Xiuli Peng, Igor Almeida, Michael Sherman, Chuan Xiao, Jianjun Sun   +12 more
doaj   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice

mSphere, 2020
Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have complicated the ...
Fabiana Freire Mendes de Oliveira, Sireesha Mamillapalli, Srinivas Gonti, Robert N. Brey, Han Li, Jarad Schiffer, Arturo Casadevall, James G. Bann   +7 more
doaj   +1 more source

Decoding Biothreats With FT‐ICR‐MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Genome sequencing is the gold standard for microbial identification. However, it fails to distinguish closely related species with overlapping genetic features. This is the case of Bacillus cereus and Bacillus cytotoxicus, two members of the B. cereus group with distinct pathogenic profiles. While B. cereus, a well‐known opportunistic pathogen
Maria Inês Romão, Inês Gomes, Wilson Antunes, Petr Novak, Marta Sousa Silva, Carlos Cordeiro   +5 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source