Results 71 to 80 of about 8,844 (171)

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

Toxins, 2010
Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White, Chih-Shia Lee, Nicholas Duesbery   +2 more
doaj   +1 more source

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 439-451, March 2026.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

Novel applications of the tomato microbiome: Roles and considerations for agriculture, human health, and society

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 530-555, March 2026.
Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert, Kathryn Kingsley, Peerapol Chiaranunt, James F. White   +3 more
wiley   +1 more source

Experts' Opinion on Decontamination and Antidote Strategies: Complementing Contemporary Expert Consensus and Evidence to Optimize Preparedness and Response to CBRN Threats in the Middle East and North Africa

Journal of Contingencies and Crisis Management, Volume 34, Issue 1, March 2026.
ABSTRACT Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating challenges, particularly in geopolitically unstable regions such as the Middle East and North Africa. Despite advances, gaps exist regarding optimal decontamination protocols and agent‐specific antidote selection algorithms, exacerbated by variable operational ...
Hassan Farhat, Derrick Tin, Heejun Shin, Saleh Fares Al‐Ali, Daren Morchrie, Brendon Morris, Gregory Ciottone   +6 more
wiley   +1 more source

A Human/Murine Chimeric Fab Antibody Neutralizes Anthrax Lethal Toxin In Vitro

Clinical and Developmental Immunology, 2013
Human anthrax infection caused by exposure to Bacillus anthracis cannot always be treated by antibiotics. This is mostly because of the effect of the remaining anthrax toxin in the body.
Guipeng Ding, Ximin Chen, Jin Zhu, Nicholas S. Duesbery, Xunjia Cheng, Brian Cao   +5 more
doaj   +1 more source

Anthrax: Transmission, Pathogenesis, Prevention and Treatment

Toxins
Bacillus anthracis is a deadly pathogen that under unfavourable conditions forms highly resistant spores which enable them to survive for a long period of time. Spores of B.
Nitika Sangwan, Aakriti Gangwal, Preksha Jain, Chokey Langtso, Shruti Srivastava, Uma Dhawan, Renu Baweja, Yogendra Singh   +7 more
doaj   +1 more source

Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system

mBio
Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Jie Liu, Zehua Zuo, Rasem Fattah, Toren Finkel, Stephen H. Leppla, Shihui Liu   +5 more
doaj   +1 more source

Anthrax toxins and the host: a story of intimacy

Cellular Microbiology, 2003
Although the dramatic events of the year 2001 have revitalized the interest in anthrax, research on Bacillus anthracis and its major virulence factors is one of the oldest theme in microbiology and started with the early works of Robert Koch and Louis Pasteur. The anthrax toxins are central to anthrax pathogenesis. They were discovered in the mid-1950s
Michèle, Mock, Tâm, Mignot
openaire   +2 more sources

Raxibacumab: potential role in the treatment of inhalational anthrax

Infection and Drug Resistance, 2014
Carlos E KummerfeldtDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USAAbstract: Anthrax is a highly contagious and potentially fatal human disease caused by Bacillus anthracis, an ...
Kummerfeldt CE
doaj  

Anthrax Toxins—Roadblocks for Exocytic Trafficking [PDF]

Developmental Cell, 2010
Anthrax toxins cause vascular dysfunction, in part by perturbing the endothelial cell barrier. Reporting in Nature, Guichard et al. shed new light on the mechanism by which this occurs and show that anthrax toxins interfere with exocytic delivery of cadherins to endothelial cell junctions by antagonizing the exocyst complex.
openaire   +2 more sources