The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +3 more sources
BMC Infectious Diseases, 2018 Background Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the early stage.
Qi Tang +7 more
doaj +1 more source
Lawrence O. Gostin on Biosecurity Policy: Are We Safer Today? [PDF]
, 2008 World-acclaimed authority Lawrence O. Gostin analyzes biosecurity policy since 9/11. He begins with the question: Are we safer now? Then comes a review of biosecurity legislation, followed by discussion of planning to deal with specific diseases and the ...
Gostin, Lawrence O.
core +1 more source
Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis. [PDF]
Front Cell Dev Biol, 2023 Huang X +7 more
europepmc +1 more source
Treatment of ovarian cancer with modified anthrax toxin. [PDF]
Proc Natl Acad Sci U S A, 2022 Aktories K.
europepmc +1 more source
Identification, and Clinical Relevance of Gram–Positive Spore Formers [PDF]
, 2010 The gram positive spore former constitutes a group of widely distributed infectious microorganism which has posed serious threat to public health. This group comprises the Bacillus, Clostridium, Staphylococcus and Streptococcus species.
Ajani, Olayinka O., Nwinyi, Obinna
core
DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin. [PDF]
Sci Rep, 2023 Becker L, Plückthun A.
europepmc +1 more source
The US Statement at the Fifth Review Conference: Compounding the Error in Rejecting the Composite Protocol [PDF]
, 2002 Ye
Dando, Malcolm R. +2 more
core
Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra
, 2015 The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson +4 more
core +1 more source
Multiple stages of evolutionary change in anthrax toxin receptor expression in humans. [PDF]
Nat Commun, 2021 Choate LA +7 more
europepmc +1 more source