Results 111 to 120 of about 10,314 (165)

Anthrax Toxin Targeting of Myeloid Cells through the CMG2 Receptor Is Essential for Establishment of Bacillus anthracis Infections in Mice

, 2010
SummaryBacillus anthracis kills through a combination of bacterial infection and toxemia. Anthrax toxin working via the CMG2 receptor mediates lethality late in infection, but its roles early in infection remain unclear.
Inka Sastalla, Miller-Randolph, Sharmina, Liu, Shihui, Devorah Crown, Mahtab Moayeri, Crown, Devorah, Shu Okugawa, Okugawa, Shu, Stephen H. Leppla, Leppla, Stephen H., Moayeri, Mahtab, Sastalla, Inka, Sharmina Miller-Randolph, Shihui Liu   +13 more
core   +1 more source

Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin. [PDF]

Pharmaceutics, 2021
Becker L, Singh Badwal J, Brandl F, Verdurmen WPR, Plückthun A.   +4 more
europepmc   +1 more source

Latest therapeutic target for gastric cancer: Anthrax toxin receptor 1. [PDF]

World J Gastrointest Oncol, 2021
Sun KR, Lv HF, Chen BB, Nie CY, Zhao J, Chen XB.   +5 more
europepmc   +1 more source

Recombinant Anthrax Toxin Receptor-Fc Fusion Proteins Produced in Plants Protect Rabbits against Inhalational Anthrax†

, 2010
Inhalational anthrax, a zoonotic disease caused by the inhalation of Bacillus anthracis spores, has a 50% fatality rate even when treated with antibiotics.
Simone Haase, Stephen H. Leppla, Leah Schaefer, James M. Maclean, Keith L. Wycoff, Johnny W. Peterson, Jennifer Pawlik, Dorothée Deppe, Anke K. Trilling, Shihui Liu, Archana Belle, Isin N. Geren   +11 more
core   +1 more source

CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin. [PDF]

Front Pharmacol, 2021
Hirschenberger M, Stadler N, Fellermann M, Sparrer KMJ, Kirchhoff F, Barth H, Papatheodorou P.   +6 more
europepmc   +1 more source

Receptors of anthrax toxin and cell entry

Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 ...
van der Goot, Gisou, Young, John A. T.
core   +1 more source

Drug Repurposing Using the Anthrax Toxin Internalization Pathway

, 2017
Pathogens and pathogenic agents such as lethal toxin, exploit host proteins for their success. Antibiotic discovery efforts have been focused on developing drugs that selectively target pathogens, despite the potential for drug resistance and providing ...
Zilbermintz, Leeor
core   +1 more source

Ecological Niche Model of Bacillus cereus Group Isolates Containing a Homologue of the pXO1 Anthrax Toxin Genes Infecting Metalworkers in the United States. [PDF]

Pathogens, 2022
Deka MA, Marston CK, Garcia-Diaz J, Drumgoole R, Traxler RM.   +4 more
europepmc   +1 more source

Disruption of anthrax toxin receptor 1 in pigs leads to a rare disease phenotype and protection from senecavirus A infection. [PDF]

Sci Rep, 2022
Chen PR, Rowland RRR, Stoian AM, Petrovan V, Sheahan M, Ganta C, Cino-Ozuna G, Kim DY, Dunleavey JM, Whitworth KM, Samuel MS, Spate LD, Cecil RF, Benne JA, Yan X, Fang Y, Croix BS, Lechtenberg K, Wells KD, Prather RS.   +19 more
europepmc   +1 more source

BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

, 2015
Anthrax lethal toxin, composed of protective antigen and lethal factor, was tested for cytotoxicity to human melanoma cell lines and normal human cells. Eleven of 18 melanoma cell lines were sensitive to anthrax lethal toxin (IC50 < 400 pmol/L) and 10 of
Frankel, Arthur E., Duesbery, Nicholas S., Leppla, Stephen H., Urieto, Jeffrey O., Abi-Habib, Ralph J.   +4 more
core   +1 more source