Results 1 to 10 of about 525,418 (162)

Recombinant full-length Bacillus Anthracis protective antigen and its 63 kDa form elicits protective response in formulation with addavax [PDF]

Frontiers in Immunology, 2023
IntroductionBacillus anthracis is the causative agent for the lethal disease anthrax, primarily affecting animals and humans in close contact with an infected host. The pathogenicity of B. anthracis is attributed to the secreted exotoxins and their outer
Shikhar Sharma, Shikhar Sharma, Vanndita Bahl, Gaurav Srivastava, Risha Shamim, Rakesh Bhatnagar, Deepak Gaur   +6 more
doaj   +4 more sources

PaR1 secreted by the type IX secretion system is a protective antigen of Riemerella anatipestifer [PDF]

Frontiers in Microbiology, 2023
Riemerella anatipestifer mainly infects domestic ducks, geese, turkeys, and other birds, and causes considerable economic losses to the global duck industry. Previous studies have shown that concentrated cell-free culture filtrates of R.
Jialing Wang, Yan Chen, Xiaohua He, Xiaoli Du, Yongheng Gao, Xinggen Shan, Zhiqun Hu, Qinghai Hu   +7 more
doaj   +2 more sources

Impact of HLA Polymorphism on the Immune Response to Bacillus Anthracis Protective Antigen in Vaccination versus Natural Infection [PDF]

Vaccines, 2022
The causative agent of anthrax, Bacillus anthracis, evades the host immune response and establishes infection through the production of binary exotoxins composed of Protective Antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF).
Stephanie Ascough, Rebecca J. Ingram, Karen K. Y. Chu, Stephen J. Moore, Theresa Gallagher, Hugh Dyson, Mehmet Doganay, Gökhan Metan, Yusuf Ozkul, Les Baillie, E. Diane Williamson, John H. Robinson, Bernard Maillere, Rosemary J. Boyton, Daniel M. Altmann   +14 more
doaj   +2 more sources

Two approaches for the stabilization of Bacillus anthracis recombinant protective antigen [PDF]

Human Vaccines & Immunotherapeutics, 2021
Anthrax is a zoonotic disease caused by the gram-positive spore-forming bacteria Bacillus anthracis. There is a need for safe, highly effective, long-term storage vaccine formulations for mass vaccination. However, the development of new subunit vaccines
Ekaterina M. Ryabchevskaya, Ekaterina A. Evtushenko, Dmitry L. Granovskiy, Peter A. Ivanov, Joseph G. Atabekov, Olga A. Kondakova, Nikolai A. Nikitin, Olga V. Karpova   +7 more
doaj   +2 more sources

Polysaccharide PCP-I isolated from Poria cocos enhances the immunogenicity and protection of an anthrax protective antigen-based vaccine [PDF]

Human Vaccines & Immunotherapeutics, 2020
Polysaccharides isolated from natural plants may represent a novel source of vaccine adjuvants. In this research, we focused on a natural plant polysaccharide, PCP-I, which is derived from Poria cocos, a Chinese traditional herbal medicine.
Kun Liu, Ying Yin, Jun Zhang, Xiaodong Zai, Ruihua Li, Hao Ma, Junjie Xu, Junjie Shan, Wei Chen   +8 more
doaj   +2 more sources

Antigenic identity of immunodominant proteins of Bacillus anthracis genovariants

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Introduction. The main biological raw materials for the production of immunobiological preparations for identification of Bacillus anthracis are its specific antigens, the protective antigen and the EA1 protein. Purpose.
Margarita P. Izhberdeeva, Anastasiya A. Sautkina, Irina A. Barkova, Dmitry V. Viktorov   +3 more
doaj   +1 more source

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications

Microorganisms, 2020
Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier, Clémence Rougeaux   +1 more
doaj   +1 more source

A Quantum Vaccinomics Approach for the Design and Production of MSP4 Chimeric Antigen for the Control of Anaplasma phagocytophilum Infections

Vaccines, 2022
Anaplasma phagocytophilum Major surface protein 4 (MSP4) plays a role during infection and multiplication in host neutrophils and tick vector cells. Recently, vaccination trials with the A.
José de la Fuente, Alberto Moraga-Fernández, Pilar Alberdi, Sandra Díaz-Sánchez, Olga García-Álvarez, Rubén Fernández-Melgar, Marinela Contreras   +6 more
doaj   +1 more source

Genetic Construction of Bacillus subtilis Recombinant Strain, Producing Protective Antigen of Anthrax Microbe

Вестник войск РХБ защиты, 2023
Anthrax is a serious infectious disease with high mortality. The epidemiological security depends on the vaccination of susceptible animals and population at risk.
N. V. Onuchina, A. V. Kuznetsovsky, A. A. Vorobyov, A. V. Filippov   +3 more
doaj   +1 more source