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Identification of other Cellular Receptors for Edema Factor of Bacillus anthracis by Independent Inhibition of Protective Antigen Evidenced by Inhibition of Embryo Growth and Angiogenesis [PDF]
Archives of Razi Institute, 2021 Edema factor (EF) is one of the major secretory proteins of anthrax bacteria along with protective antigen (PA) and lethal factor (LF). Edema factor is a calmodulin-and calcium-dependent adenylate cyclase that increases intracellular levels of cAMP ...
R Khandia +6 more
doaj +2 more sources
Early Circulating Edema Factor in Inhalational Anthrax Infection: Does It Matter? [PDF]
MicroorganismsAnthrax toxins are critical virulence factors of Bacillus anthracis and Bacillus cereus strains that cause anthrax-like disease, composed of a common binding factor, the protective antigen (PA), and two enzymatic proteins, lethal factor (LF) and edema ...
Emilie Tessier +5 more
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Small molecule inhibitors of anthrax edema factor. [PDF]
Bioorg Med Chem Lett, 2018 Anthrax is a highly lethal disease caused by the Gram-(+) bacteria Bacillus anthracis. Edema toxin (ET) is a major contributor to the pathogenesis of disease in humans exposed to B. anthracis. ET is a bipartite toxin composed of two proteins secreted by the vegetative bacteria, edema factor (EF) and protective antigen (PA). Our work towards identifying
Jiao GS +8 more
europepmc +4 more sources
Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model [PDF]
Toxins, 2016 Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis.
Taoran Zhao +10 more
doaj +2 more sources
The Value of Anlotinib in the Treatment of Intractable Brain Edema: Two Case Reports
Frontiers in Oncology, 2021 About 20-30 percent of patients with cancer, such as non-small cell lung cancer, breast cancer, melanoma and renal cell carcinoma, will develop brain metastases (BM). Primary and secondary brain tumors are often accompanied by peritumoral edema.
Song Yang +5 more
doaj +1 more source
Pathogens, 2020 : Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi +5 more
doaj +1 more source
Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications
Microorganisms, 2020 Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier +1 more
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Novel inhibitors of anthrax edema factor [PDF]
Bioorganic & Medicinal Chemistry, 2008 Several pathogenic bacteria produce adenylyl cyclase toxins, such as the edema factor (EF) of Bacillus anthracis. These disturb cellular metabolism by catalyzing production of excessive amounts of the regulatory molecule cAMP. Here, a structure-based method, where a 3D-pharmacophore that fit the active site of EF was constructed from fragments, was ...
Deliang, Chen +5 more
openaire +2 more sources
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
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Toxins, 2015 The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could be exploited as an act of terror through contamination of human ...
Bruce Huang +4 more
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