Results 41 to 50 of about 277,895 (300)

The adenylyl cyclase activity of anthrax edema factor [PDF]

Molecular Aspects of Medicine, 2009
Bacillus anthracis, the etiologic agent for anthrax, secretes edema factor (EF) to disrupt intracellular signaling pathways. Upon translocation into host cells and association with a calcium sensor, calmodulin (CaM), EF becomes a highly active adenylyl cyclase (AC) that raises the intracellular concentration of cyclic AMP (cAMP). Growing evidence shows
Wei-Jen, Tang, Qing, Guo
openaire   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. [PDF]

, 2015
Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to massive cAMP production resulting ...
Urbauer, Jeffrey L., Ramona J. Bieber Urbauer, Lübker, Carolin, Bieber Urbauer, Ramona J., Jackob Moskovitz, Seifert, Roland, Ramona Urbauer, Wei-Jen Tang, Moskovitz, Jackob, Stefan Dove, Jeffrey L. Urbauer, Jeffrey Urbauer, Carolin Lübker, Roland Seifert, Tang, Wei-Jen, Dove, Stefan   +15 more
core   +1 more source

Enzymatic vitreolysis for the treatment of tractional diabetic macular edema

Therapeutic Advances in Ophthalmology, 2019
Background: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer anti-vascular endothelial growth factor injections.
Bernardete Pessoa, João Coelho, Constança Coelho, Sílvia Monteiro, Carolina Abreu, João Figueira, Angelina Meireles, João Nuno Melo Beirão   +7 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor [PDF]

, 2013
Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs (pGCs) and a nitric oxide-activated soluble GC (sGC).
Koch, Karl-Wilhelm, Kaever, Volkhard, Burhenne, Heike, Shen, Yuequan, Seifert, Roland, Beste, Kerstin Y., Spangler, Corinna M., Tang, Wei-Jen   +7 more
core   +2 more sources

Posttraumatic brain edema: Pathophysiology, management, and current concept

Apollo Medicine, 2019
Post traumatic cerebral edema is a multiplex process. Mainly two types of cerebral edema occurred after traumatic brain injury-vasogenic edema and cytotoxic edema.
Subhas K Konar, Dhaval Shukla, Amit Agrawal   +2 more
doaj   +1 more source

Proposed Source of Chick Edema Factor

Journal of AOAC INTERNATIONAL, 1972
Abstract Possible sources of contamination of fat by chlorophenols, precursors of chlorinated benzo- p-dioxins, are reviewed. Toxic fats (fleshings grease) from hides that had been treated with pentachlorophenol were tested in feeding studies and analyzed by electron capture GLC and GLC-mass spectrometric methods.
openaire   +2 more sources

Diabetic macular edema, Risk factors and concomitants [PDF]

Acta Ophthalmologica Scandinavica, 1999
To investigate the systemic and ocular factors associated with diffuse macular edema in patients with diabetic retinopathy (DR) and compare with patients with focal or no macular edema.From 160 consecutive patients with DR, we obtained medical and ocular histories, blood pressure and visual acuity.
J M, Lopes de Faria, A E, Jalkh, C L, Trempe, J W, McMeel   +3 more
openaire   +2 more sources

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source