Results 51 to 60 of about 277,895 (300)

Induction of cytotoxic T lymphocyte response against Mycobacterial antigen using domain I of anthrax edema factor as antigen delivery system

, 2007
We have investigated the efficiency of N-terminal 1-260 residues of Edema factor (EFn) as a delivery system for ESAT-6, an antigenic protein of Mycobacterium tuberculosis H37Rv, into the cytosol of mammalian cells.
Bhatnagar, Rakesh, Midha, Shuchi, Gorantala, Jyotsna, Chandra, Subhash, Kaur, Manpreet   +4 more
core   +1 more source

Remitting seronegative symmetrical synovitis with pitting edema syndrome in maintenance hemodialysis

IJU Case Reports, 2020
Introduction The remitting seronegative symmetrical synovitis with pitting edema syndrome primarily occurs in elderly individuals to represent symptoms of edema, pain, and joint swelling.
Toru Matsugasumi, Tsuneyuki Nakanouchi, Kazuya Mikami, Takumi Shiraishi, Masatoshi Kadoya, Seijiro Toriyama, Hidefumi Taniguchi, Atsuko Fujihara, Fumiya Hongo, Osamu Ukimura   +9 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin

, 2004
The catalytic efficiency of adenylyl cyclase activity of edema factor (EF) from Bacillus anthracis is enhanced by approximately 1000-fold upon its binding to mammalian protein calmodulin (CaM). A tandem cell-based and protein binding-based screen of a 10,
Lee, Young-Sam, Bergson, Pamela, Pamela Bergson, Wei Song He, Young-Sam Lee, Wei-Jen Tang, He, Wei Song, Milan Mrksich, Tang, Wei-Jen, Mrksich, Milan   +9 more
core   +1 more source

Intravitreal anti-vascular endothelial growth factor therapy in the treatment of vision loss associated with hematologic malignancy

American Journal of Ophthalmology Case Reports
Purpose: To determine the effectiveness of anti-vascular endothelial growth factor (VEGF) therapy in the setting of optic disc edema secondary to hematologic malignancies.
Thomas P. Toohey, Jake Shortt, Nevin John, Salmaan Al-Qureshi, Sanjeewa S. Wickremasinghe   +4 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

Frontiers in Pharmacology, 2018
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested ...
Zhen-Biao Zhang, Zhen-Biao Zhang, Dan-Dan Luo, Jian-Hui Xie, Yan-Fang Xian, Zheng-Quan Lai, Zheng-Quan Lai, Yu-Hong Liu, Wei-Hai Liu, Jian-Nan Chen, Xiao-Ping Lai, Xiao-Ping Lai, Zhi-Xiu Lin, Zhi-Xiu Lin, Zi-Ren Su, Zi-Ren Su   +15 more
doaj   +1 more source

Factors influencing magnetic resonance imaging finding of endopelvic fascial edema after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids

International Journal of Hyperthermia, 2022
Objective Investigate the relationships between endopelvic fascial edema and its influencing factors after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids.Methods This retrospective study included 688 women with
Yuhang Liu, Yang Liu, Fajin Lv, Yuqing Zhong, Zhibo Xiao, Furong Lv   +5 more
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor.

, 2015
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP. Membranous AC1 (AC1) is involved in processes of memory and learning and in muscle pain.
Seifert Roland, Carolin Lübker, Roland Seifert, Lübker Carolin, Roland Seifert (104001), Carolin Lübker (735367)   +5 more
core   +1 more source