Results 31 to 40 of about 277,895 (300)

Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis

open access: yes, 2011
Bacillus anthracis overwhelms its victims by way of two toxins, namely edema toxin and lethal toxin. Lethal toxin is formed by the combination of protective antigen with lethal factor while edema toxin is formed by the combination of Protective Antigen ...
Bhatnagar, Rakesh   +3 more
core   +1 more source

Peripheral retinal leakage in POEMS syndrome

open access: yesInternational Journal of Retina and Vitreous, 2021
Background POEMS (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, skin changes) syndrome is a rare blood disorder with multi-system involvement. The cause is unknown.
Andrew Rising Carey, Praveen Jeyaseelan
doaj   +1 more source

Prevalence and Risk Factors of Pedal Edema in Chronic Leg Edema

open access: yesAnnals of Vascular Surgery
This study aimed to determine the prevalence and underlying causes of pedal edema (PE) in legs affected by chronic edema.A total of 705 legs with chronic edema, defined as persistent leg edema lasting for > 3 months, were examined in 411 patients who visited our clinic between April 2009 and March 2024. Patients with known systemic edematous conditions
Kotaro, Suehiro   +9 more
openaire   +2 more sources

Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2(3)-O-(N-methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.

open access: yes, 2009
Abbreviations AC, adenylyl cyclase; ANT, anthraniloyl-; CaM, calmodulin; CyaA, Bordetella pertussis adenylyl cyclase toxin; ESI, electrospray ionization; FRET, fluorescence resonance energy transfer; HPLC, high pressure liquid chromatography; k, capacity
Jennifer Schmidt   +16 more
core   +2 more sources

Anti-vascular endothelial growth factor therapy for diabetic macular edema

open access: yesTherapeutic Advances in Endocrinology and Metabolism, 2013
Diabetes mellitus is a serious health problem that affects over 350 million individuals worldwide. Diabetic retinopathy (DR), which is the most common microvascular complication of diabetes, is the leading cause of new cases of blindness in working-aged ...
David S. Boyer   +3 more
doaj   +1 more source

The role of anti-vascular endothelial growth factor in diabetic macular edema

open access: yesMedicina Universitaria, 2022
The continuous growing number of diabetic patients has caused a stable increase in the global prevalence of diabetes mellitus. One of the most common complications caused by diabetes is diabetic macular edema (DME).
Giovani Faustine, Ani Retno-Prijanti
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin

open access: yes, 2010
Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core   +1 more source

Diabetic macular edema: it is more than just VEGF [version 1; referees: 2 approved]

open access: yesF1000Research, 2016
Diabetic macular edema is a serious visual complication of diabetic retinopathy. This article reviews the history of previous and current therapies, including laser therapy, anti-vascular endothelial growth factor agents, and corticosteroids, that have ...
Michael A. Singer   +4 more
doaj   +1 more source

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