Results 11 to 20 of about 277,895 (300)

Anthrax edema factor toxicity is strongly mediated by the N-end rule. [PDF]

PLoS ONE, 2013
Anthrax edema factor (EF) is a calmodulin-dependent adenylate cyclase that converts adenosine triphosphate (ATP) into 3'-5'-cyclic adenosine monophosphate (cAMP), contributing to the establishment of Bacillus anthracis infections and the resulting ...
Clinton E Leysath, Damilola D Phillips, Devorah Crown, Rasem J Fattah, Mahtab Moayeri, Stephen H Leppla   +5 more
doaj   +2 more sources

Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

Toxins, 2012
Antibiotic treatment may fail to protect individuals, if not started early enough, after infection with Bacillus anthracis, due to the continuing activity of toxins that the bacterium produces.
Maria Estrella Jimenez, Laurie E. Sower, Mary A. Walter, Scott R. Gilbertson, Johnny W. Peterson, John J. Kanalas, Jian Gao, Lili Ma, Deliang Chen, Catherine H. Schein   +9 more
doaj   +2 more sources

Anthrax Vaccine Precipitated Induces Edema Toxin-Neutralizing, Edema Factor-Specific Antibodies in Human Recipients. [PDF]

Clin Vaccine Immunol, 2017
Edema toxin (ET), composed of edema factor (EF) and protective antigen (PA), is a virulence factor of Bacillus anthracis that alters host immune cell function and contributes to anthrax disease.
Dumas EK, Gross T, Larabee J, Pate L, Cuthbertson H, Charlton S, Hallis B, Engler RJM, Collins LC, Spooner CE, Chen H, Ballard J, James JA, Farris AD.   +13 more
europepmc   +2 more sources

A Simple Luminescent Adenylate-Cyclase Functional Assay for Evaluation of Bacillus anthracis Edema Factor Activity. [PDF]

Toxins (Basel), 2016
Edema Factor (EF), the toxic sub-unit of the Bacillus anthracis Edema Toxin (ET) is a calmodulin-dependent adenylate cyclase whose detrimental activity in the infected host results in severe edema. EF is therefore a major virulence factor of B. anthracis.
Israeli M, Rotem S, Elia U, Bar-Haim E, Cohen O, Chitlaru T.   +5 more
europepmc   +2 more sources

The effects of intravitreal adalimumab injection on pseudophakic macular edema

BMC Research Notes, 2020
Objective Pseudophakic macular edema is a frequent complication following cataract surgery. Inflammation is a major etiologic factor in the development of pseudophakic cystoid macular edema.
Mohsen Farvardin, Ehsan Namvar, Fatemeh Sanie-Jahromi, Mohammad Karim Johari   +3 more
doaj   +1 more source

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger, Anika Bronnhuber, Benz, Roland, Hajós György, Markus Huber-Lang, Hajós, György, Kerstin Duscha, Riedl Zsuzsanna, Beitzinger, Christoph, Riedl, Zsuzsanna, Duscha Kerstin, György Hajós, Huber-Lang Markus, Beitzinger Christoph, Barth Holger, Duscha, Kerstin, Bronnhuber, Annika, Benz Roland, Christoph Beitzinger, Roland Benz, Holger Barth, Bronnhuber Anika, Bronnhuber, Anika, Huber-Lang, Markus, Zsuzsanna Riedl   +24 more
core   +1 more source

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins

Membranes, 2016
Tethered lipid bilayer membranes (tBLMs) have been used in many applications, including biosensing and membrane protein structure studies. This report describes a biosensor for anthrax toxins that was fabricated through the self-assembly of a tBLM with B.
Vitalii Silin, John J. Kasianowicz, Ariel Michelman-Ribeiro, Rekha G. Panchal, Sina Bavari, Joseph W. F. Robertson   +5 more
doaj   +1 more source

Topographic patterns of retinal edema in eyes with branch retinal vein occlusion and their association with macular edema recurrence

Scientific Reports, 2021
In this study, we evaluated the topographic pattern of retinal edema in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) using a widefield retinal thickness map of optical coherence tomography and its association with ME ...
Hae Min Park, Young Hwan Kim, Byung Ro Lee, Seong Joon Ahn   +3 more
doaj   +1 more source

Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy

Neural Regeneration Research, 2023
Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease, is the leading cause of visual impairment in diabetic patients.
Lei Tang, Guo-Tong Xu, Jing-Fa Zhang
doaj   +1 more source

Antibodies against Anthrax: Mechanisms of Action and Clinical Applications

Toxins, 2011
B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule.
Thibaut Pelat, Philippe Thullier, Jeffrey W. Froude II   +2 more
doaj   +1 more source