Results 21 to 30 of about 1,531,051 (248)

Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor

Toxins, 2016
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li, Qiang Guo, Ju Liu, Jun Zhang, Ying Yin, Dayong Dong, Ling Fu, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission [PDF]

, 2016
BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa.
Scoles, Glen A., Stephen Mwaura, Odongo, David O., Glen A. Scoles, David O. Odongo, Olds, Cassandra L., David Odongo (3497480), Richard Bishop (59737), Richard Bishop, Claudia Daubenberger (212658), Glen Scoles (3448283), Daubenberger, Claudia, Stephen Mwaura (3485219), Bishop, Richard, Cassandra L. Olds, Mwaura, Stephen, Claudia Daubenberger, Cassandra Olds (3485216)   +17 more
core   +1 more source

Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study

Toxins, 2016
Nearly all the cationic molecules tested so far have been shown to reversibly block K+ current through the cation-selective PA63 channels of anthrax toxin in a wide nM–mM range of effective concentrations.
Goli Yamini, Nnanya Kalu, Ekaterina M. Nestorovich   +2 more
doaj   +1 more source

Immunity to Intracellular Salmonella Depends on Surface-associated Antigens [PDF]

, 2012
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Rizos Konstantin, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Somedutta Barat (126107), Barat, Somedutta, Rizos, K., Bumann, D., Schemmer, Anne K, Claudi Beatrice, Neil Burton (126123), Anne K Schemmer, Barat Somedutta, Dennis Kirchhoff (126121), Somedutta Barat, Alexander Schmidt (68515), Kirchhoff, D., Alain Mazé, Willer, Yvonne, Anne K. Schemmer (126119), Kirchhoff Dennis, Rizos, Konstantin, Dennis Kirchhoff, Bumann, Dirk, Burton Neil, Schemmer, A., Claudi, B., Mazé, Alain, Schmidt Alexander, Schemmer Anne K., Yvonne Willer (126110), Konstantin Rizos (126113), Willer Yvonne, Yvonne Willer, Willer, Y., Burton, Neil, Bumann Dirk, Alexander Schmidt, Mazé Alain, Beatrice Claudi, Schmidt, A., Alain Mazé (126117), Mazé, A., Claudi, Beatrice, Kirchhoff, Dennis, Barat, S., Konstantin Rizos, Burton, N., Schemmer, Anne K., Schmidt, Alexander, Neil Burton   +50 more
core   +2 more sources

Protective Antigen-Specific Memory B Cells Persist Years after Anthrax Vaccination and Correlate with Humoral Immunity

Toxins, 2014
Anthrax Vaccine Adsorbed (AVA) generates short-lived protective antigen (PA) specific IgG that correlates with in vitro toxin neutralization and protection from Bacillus anthracis challenge.
Lori Garman, Kenneth Smith, A. Darise Farris, Michael R. Nelson, Renata J. M. Engler, Judith A. James   +5 more
doaj   +1 more source

Vaccine development against tuberculosis before and after Covid-19

Frontiers in Immunology, 2023
Coronavirus disease (Covid-19) has not only shaped awareness of the impact of infectious diseases on global health. It has also provided instructive lessons for better prevention strategies against new and current infectious diseases of major importance.
Stefan H. E. Kaufmann, Stefan H. E. Kaufmann, Stefan H. E. Kaufmann   +2 more
doaj   +1 more source

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source

Evaluation of Cellular Immunity with ASFV Infection by Swine Leukocyte Antigen (SLA)—Peptide Tetramers

Viruses, 2021
African swine fever virus (ASFV) causes acute hemorrhagic fever in domestic pigs and wild boars, resulting in incalculable economic losses to the pig industry. As the mechanism of viral infection is not clear, protective antigens have not been discovered
Wenqiang Sun, He Zhang, Wenhui Fan, Lihong He, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Rongliang Hu, Tingrong Luo, Wenjun Liu, Jing Li   +11 more
doaj   +1 more source

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]

, 2013
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
Stylianou, E, Gil Reynolds Diogo, Reljic Rajko, Matthew J Paul, Pepponi Ilaria, Ma Julian K.-C., Julian K.-C. Ma, Drake, PM, Diogo Gil Reynolds, Drake Pascal M. W., Matthew J. Paul, Pepponi, I, Pascal M. W. Drake, Pascal M W Drake, van Dolleweerd Craig, Diogo, GR, Elena Stylianou, Craig van Dolleweerd, Rajko Reljic, Julian K-C Ma, Reljic, R, Ilaria Pepponi, van Dolleweerd, C, Paul Matthew J., Stylianou Elena, Ma, JK, Paul, MJ   +26 more
core   +2 more sources

Changes in Biomodels in Response to Recombinant Protective Anthrax Antigen Inoculation

Проблемы особо опасных инфекций, 2013
one. The data obtained has substantiated the lack of an expressed damaging effect of the recombinant protective antigen on the cells and tissues of the macro­organism, as well as possibility of its application as one of the core components of the ...
P. Yu. Popova, S. A. Bugorkova, N. I. Mikshis, A. P. Semakova, Yu. A. Popov, T. N. Shchukovskaya   +5 more
doaj   +1 more source