Results 21 to 30 of about 527,152 (301)
Why is a protective antigen protective?
Human Vaccines, 2009 One of the major challenges in vaccine development is the identification of microbial components that give rise to a protective immune response. Over the last decade, genome and proteome-based methods have proven successful in discovering new vaccine candidates for many pathogens through the selection of secreted or surface-exposed protein antigens and
L.J. Gourlay +5 more
openaire +7 more sources
Atomic structure of anthrax protective antigen pore elucidates toxin translocation [PDF]
, 2014 Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals.
R. John Collier +10 more
core +1 more source
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
Toxins, 2016 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li +8 more
doaj +1 more source
Evaluation of Crude Anthrax Protective Antigen as an Adjutant For Brucella Abortus Vaccine In Mice [PDF]
Engineering and Technology Journal, 2012 Anthrax crude protective antigen (PA) was used in this study as an adjutant with Brucella abortus S19 strain vaccine in a ratio of 1:1 to immunize mice in dose of 0.1 ml s/c in order to decrease side effects of S19 vaccine and also to enhance its ...
Inam Jasim Lafta
doaj +1 more source
VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines [PDF]
BMC Bioinformatics, 2007 Vaccine development in the post-genomic era often begins with the in silico screening of genome information, with the most probable protective antigens being predicted rather than requiring causative microorganisms to be grown. Despite the obvious advantages of this approach--such as speed and cost efficiency--its success remains dependent on the ...
Irini A. Doytchinova, Darren R. Flower
openaire +4 more sources
Toxins, 2016 Nearly all the cationic molecules tested so far have been shown to reversibly block K+ current through the cation-selective PA63 channels of anthrax toxin in a wide nM–mM range of effective concentrations.
Goli Yamini +2 more
doaj +1 more source
Toxins, 2014 Anthrax Vaccine Adsorbed (AVA) generates short-lived protective antigen (PA) specific IgG that correlates with in vitro toxin neutralization and protection from Bacillus anthracis challenge.
Lori Garman +5 more
doaj +1 more source
Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague
Biomolecules, 2020 Despite the relatively low incidence of plague, its etiological agent, Yersinia pestis, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant Y.
Andrey A. Byvalov +4 more
doaj +1 more source
Changes in Biomodels in Response to Recombinant Protective Anthrax Antigen Inoculation
Проблемы особо опасных инфекций, 2013 one. The data obtained has substantiated the lack of an expressed damaging effect of the recombinant protective antigen on the cells and tissues of the macroorganism, as well as possibility of its application as one of the core components of the ...
P. Yu. Popova +5 more
doaj +1 more source
Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [PDF]
, 2004 Background: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors.
Jiang, I. +29 more
core +1 more source