Results 11 to 20 of about 527,152 (301)
Проблемы особо опасных инфекций, 2012 Assessment of immunogenicity and biological safety of protective antigen preparation obtained from asporogenic recombinant producer, B. anthracis 55ΔTPA-1(Spo-), is made on the mice (BALB/c species) and Guiney pigs models.
P. Yu. Popova +9 more
doaj +3 more sources
Research on Detection of Ultra-Low Concentration Anthrax Protective Antigen Using Graphene Field-Effect Transistor Biosensor. [PDF]
Sensors (Basel), 2023 Background: Protective antigen (PA) is an important biomarker for the early diagnosis of anthrax, and the accurate detection of protective antigen under extremely low concentration conditions has always been a hot topic in the biomedical field.
Liang T, Chen J, Yan R, Jiang H, Li H.
europepmc +2 more sources
IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells. [PDF]
ACS Cent Sci, 2021 © 2020 American Chemical Society. All rights reserved. Therapeutic immunotoxins composed of antibodies and bacterial toxins provide potent activity against malignant cells, but joining them with a defined covalent bond while maintaining the desired ...
Lu Z +6 more
europepmc +2 more sources
Anthrax protective antigen is a calcium-dependent serine protease. [PDF]
Virulence, 2018 Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor.
Storm L +7 more
europepmc +3 more sources
Immunotropic and Immunogenic Properties of Nonspecific Yersinia Porins
Вестник войск РХБ защиты, 2023 The purpose of the study is to summarize our own data and literature data on the significance of poreforming proteins of the outer membrane of Yersinia as factors of their pathogenicity and as diagnostic and protective antigens, and their role in ...
O. D. Novikova +3 more
doaj +1 more source
New protective antigen of group A streptococci [PDF]
Journal of Clinical Investigation, 1999 It is widely believed that the surface M protein of group A streptococci is the predominant surface protein of these organisms containing opsonic epitopes. In the present study, we identified a new surface protein, distinct from M protein, that evokes protective antibodies.
J B, Dale +4 more
openaire +2 more sources
Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]
, 2013 Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger +24 more
core +1 more source
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
doaj +1 more source
Antigens of Bordetella pertussis.III. The Protective Antigen
Experimental Biology and Medicine, 1963 SummaryA method of preparing extracts from Bordetella pertussis with high protective and histamine sensitizing activity is described. From these extracts, starch block electrophoresis yielded active purified fractions which not only protected mice against intracerebral challenge with living B. pertussis cells but also sensitized mice to histamine. From
J, MUNOZ, B M, HESTEKIN
openaire +2 more sources
Trimethyl Chitosan Nanoparticles Encapsulated Protective Antigen Protects the Mice Against Anthrax
Frontiers in Immunology, 2018 Anthrax is an era old deadly disease against which there are only two currently available licensed vaccines named anthrax vaccine adsorbed and precipitated (AVP).
Anshu Malik +4 more
doaj +1 more source