Results 41 to 50 of about 531,678 (162)

Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity

Toxins, 2012
Bacillus anthracis secretes exotoxins which act through several mechanisms including those that can subvert adaptive immunity with respect both to antigen presenting cell and T cell function.
Daniel M. Altmann, Rebecca J. Ingram, Stephanie Ascough   +2 more
doaj   +1 more source

Antibodies against Anthrax: Mechanisms of Action and Clinical Applications

Toxins, 2011
B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule.
Thibaut Pelat, Philippe Thullier, Jeffrey W. Froude II   +2 more
doaj   +1 more source

Cloning, expression and sequence analysis of Al gene in Aeromonas hydrophila strains TPS-30 and BSK-10

浙江大学学报. 农业与生命科学版, 2010
Adhesin is an important pathogenic factor of Aeromonas hydrophila which can cause disease in most fish in the area of Jiangsu and Zhejiang. The strains of TPS-30 and BSK-10 were assigned to serogroup O:9 and O:97 respectively, and the genes of the major ...
PAN Xiao-yi, SHEN Jin-yu, HAO Gui-jie, YAO Jia-yun, XU Yang   +4 more
doaj   +1 more source

Immunization with Individual Proteins of the Lrp/AsnC Family Induces Protection Against Brucella melitensis 16M Challenges in Mice

Frontiers in Microbiology, 2015
Brucellosis is one of the most common zoonoses worldwide. Subunit vaccines are promising for the prevention of human brucellosis. In our previous protective antigen screening studies, we identified a new protective antigen, BMEI0357, which belongs to the
Xinhui eWang, Xinhui eWang, Xinhui eWang, Chang eAn, Chang eAn, Mingjuan eYang, Xinran eLi, Xinran eLi, Yuehua eKe, Shuangshuang eLei, Xiaoyang eXu, Jiuxuan eYu, Hang eRen, xinying eDu, zhoujia ewang, Yefeng eQiu, Bo eLiu, Zeliang eChen   +17 more
doaj   +1 more source

Bispecific antibody engineered from two non-protective antibodies confers full protection against anthrax toxin through inhibition of PA83 cleavage

Microbiology Spectrum
Anthrax is a highly contagious zoonotic disease, posing a great threat to human life and health. Protective antibodies against anthrax protective antigens (PA) can play a crucial role in the prevention and treatment of anthrax infections.
Zhengshan Chen, Guanying Zhang, Jin Han, Zheng Zhu, Meirong Wang, Ting Fang, Zeya Li, Yunzhu Dong, Jianmin Li, Changming Yu, Xiangyang Chi   +10 more
doaj   +1 more source

Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax

Toxins, 2015
The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could be exploited as an act of terror through contamination of human ...
Bruce Huang, Tao Xie, David Rotstein, Hui Fang, David M. Frucht   +4 more
doaj   +1 more source

A STUDY ON THE PROTECTIVE ANTIGEN OF PSEUDOMONAS AERUGINOSA

Nippon Jibiinkoka Gakkai Kaiho, 1966
It has been generally accepted that Pseudo- monas aeruginosa is one of the organisms most resistant to antibiotics. In the present study, Pseudomonas aeruginosa strain A3 was pursued in mice revealing its protective antigen localed in its cell wall. Preparation of cell walls during the present experiments was performed with mechanical des- truction and
openaire   +3 more sources

Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain

Toxins, 2017
The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease.
Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. O’Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White, Mark T. Fisher   +10 more
doaj   +1 more source

The Role of Russian Scientists in the Development of Anthrax Vaccines

Aktualʹnaâ Infektologiâ, 2015
In Russia in the second half of the XIX century, research schools developing anthrax vaccines for agriculture were formed. According to their level, they are not inferior to similar Western schools.
M.V. Supotnytskyi, I.V. Borysevych, V.I. Klymov, O.M. Shevtsov, M.Yu. Lub, A.S. Tumanov   +5 more
doaj   +1 more source

Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design

Frontiers in Immunology, 2017
With many protective vaccine antigens reported in the literature and verified experimentally, how to use the knowledge mined from these antigens to support rational vaccine design and study underlying design mechanism remains unclear. In order to address
Edison Ong, Mei U Wong, Yongqun He, Yongqun He   +3 more
doaj   +1 more source