Results 61 to 70 of about 527,152 (301)

Protective antigen complexes with increased stability and uses thereof

, 2018
WSU inventor: James G. Bann, Dept. of Chemistry, College of Liberal Arts and SciencesApplication No: 15/886112 filed February 1, 2018. Patent No: US 20180169208 A1 granted June 21, 2018.Immunogenic compositions against Bacillus anthracis comprising a ...
Miyagi, Masaru, Bann, James G.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of Bacillus subtilis strain IS53 for the production of Bacillus anthracis protective antigen

, 1994
An asporogenous strain of Bacillus subtilis, IS53, transformed with plasmid pPA102, produces the protective antigen (PA) component of the tripartite toxin of B. anthracis.
Baillie, Les, Manchee, R. J., Johnson, M.   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phage Display Analysis of Monoclonal Antibody Binding to Anthrax Toxin Lethal Factor

Toxins, 2017
AVR1674 and AVR1675 are monoclonal antibodies (mAbs) that bind with high specificity to anthrax toxin lethal factor (LF) and lethal toxin (LTx).
Jason M. Goldstein, Joo Lee, Xiaoling Tang, Anne E. Boyer, John R. Barr, Dennis A. Bagarozzi Jr., Conrad P. Quinn   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

Toxins, 2012
Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman   +8 more
doaj   +1 more source

Rapid and Sensitive Multiplex Assay for the Detection of B. anthracis Spores from Environmental Samples

Pathogens, 2020
: Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi, Orly Laskar, Itai Glinert, Ron Alcalay, Adva Mechaly, Haim Levy   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Role of residues constituting the 2β1 strand of domain II in the biological activity of anthrax protective antigen

, 2001
Anthrax toxin consists of three proteins, protective antigen, lethal factor and oedema factor. A proteolytically activated 63-kDa fragment of protective antigen binds lethal factor/oedema factor and translocates them into the cytosol.
Arora, Naveen, Chaudhry, Ashutosh, Khanna, Hemant, Chopra, Arun P., Singh, Yogendra   +4 more
core   +1 more source