Results 51 to 60 of about 1,531,051 (248)

Cell biology and immunology of malaria.

, 2011
Malaria is a vector-borne infectious disease caused by unicellular parasites of the genus Plasmodium. These obligate intracellular parasites have the unique capacity to infect and replicate within erythrocytes, which are terminally differentiated host ...
Matuschewski, K., Hafalla, J., Matuschewski, Kai, Julius Clemence Hafalla, Kai Matuschewski, Silvie, Olivier, Olivier Silvie, Hafalla, Julius Clemence, Silvie, O.   +8 more
core   +1 more source

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen. [PDF]

, 2002
In order to identify T cell epitopes within the Mycobacterium leprae 45-kD serine-rich antigen, we analysed responses to overlapping 17-mer peptides encompassing the whole antigen in non-exposed UK controls, Pakistani leprosy patients and tuberculosis ...
Zafar, S, Dawood, G, Drijfhout, JW, Smith, S, Lopez, FV, Bothamley, G, Brahmbhatt, S, Hussain, R, Dockrell, HM, Ottenhoff, THM   +9 more
core   +1 more source

Immunoproteomic Screening of Candidate Antigens for the Preliminary Development of a Novel Multi-Component and Multi-Epitope Vaccine Against Streptococcus suis Infection

Vaccines
Background/Objectives: Streptococcus suis (SS), an important zoonotic pathogen, has caused significant economic losses to the global pig industry. Existing commercial vaccines for SS mainly provide effective protection against a single serotype.
Yue Zhang, Caiying Li, Yutong Feng, Qibing Gu, Jinwang Hu, Yuhang Li, Lu Xia, Shaopo Zu   +7 more
doaj   +1 more source

Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain

Toxins, 2017
The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease.
Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. O’Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White, Mark T. Fisher   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [PDF]

, 1996
Western blot analysis using an anti-globin rabbit serum Rb94 revealed a major band of 17 kDa in extracts of Ostertagia ostertagi adults and 4th-stage larvae.
De Marez, Tine, Blaxter, Mark L, Berghen, Paul, Raes, Stefaan, Blaxter, M. L., de Marez, T. M., Berghen, P., de Marez, T.M., Vercruysse, J., de Graaf, Dirk, Raes, S., Vercruysse, Jozef, Moens, L., de Graaf, D.C., Moens, Luc, Blaxter, M.L., de Graaf, D. C.   +16 more
core   +1 more source

A niosome formulation modulates the Th1/Th2 bias immune response in mice and also provides protection against anthrax spore challenge

International Journal of Nanomedicine, 2018
Himanshu Gogoi, Rajesh Mani, Rakesh Bhatnagar Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India Introduction: In this study, we have investigated the immunogenicity and ...
Gogoi H, Mani R, Bhatnagar R
doaj  

The Role of Russian Scientists in the Development of Anthrax Vaccines

Aktualʹnaâ Infektologiâ, 2015
In Russia in the second half of the XIX century, research schools developing anthrax vaccines for agriculture were formed. According to their level, they are not inferior to similar Western schools.
M.V. Supotnytskyi, I.V. Borysevych, V.I. Klymov, O.M. Shevtsov, M.Yu. Lub, A.S. Tumanov   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design

Frontiers in Immunology, 2017
With many protective vaccine antigens reported in the literature and verified experimentally, how to use the knowledge mined from these antigens to support rational vaccine design and study underlying design mechanism remains unclear. In order to address
Edison Ong, Mei U Wong, Yongqun He, Yongqun He   +3 more
doaj   +1 more source