Results 1 to 10 of about 67,942 (278)

Proteomics study of anthrax lethal toxin-treated murine macrophages

Electrophoresis, 2006
exaly  

Synthetic inhibitors of anthrax lethal toxin

2005
Bracci L, PINI, ALESSANDRO, Runci Y, FALCIANI, CHIARA, Ricci C, Bernini A, NICCOLAI, NERI, Fabbrini M, Lelli B, Lozzi L, Neri P.   +10 more
openaire   +1 more source

Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]

PLoS Pathogens, 2006
Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G Jonah A Rainey, D Borden Lacy, Marianne Manchester, R John Collier, John A T Young   +8 more
doaj   +8 more sources

Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. [PDF]

PLoS Pathogens, 2017
Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.
Sudarshan Seshadri, David S J Allan, James R Carlyle, Lauren A Zenewicz   +3 more
doaj   +3 more sources

Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system [PDF]

MBio
Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Zehua Zuo, Rasem Fattah, Toren Finkel
exaly   +4 more sources

Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]

PLoS ONE, 2013
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen, Hsin-Hou Chang, Guan-Ling Lin, Tsung-Pao Wang, Yi-Ling Lai, Ting-Kai Lin, Ming-Chun Hsieh, Jyh-Hwa Kau, Hsin-Hsien Huang, Hui-Ling Hsu, Chi-Yuan Liao, Der-Shan Sun   +11 more
doaj   +5 more sources

The Effects of Anthrax Lethal Toxin on Host Barrier Function

Toxins, 2011
The pathological actions of anthrax toxin require the activities of its edema factor (EF) and lethal factor (LF) enzyme components, which gain intracellular access via its receptor-binding component, protective antigen (PA).
David M Frucht, Frucht David M
exaly   +4 more sources

Neutro"feels" lethal toxin. [PDF]

J Leukoc Biol, 2020
Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils.
Mazgaeen L, Gurung P.
europepmc   +4 more sources

Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action [PDF]

Toxins
Bacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva, Maksim A. Marin, Anastasia A. Ershova, Alena K. Ryabko, Yana O. Romanenko, Tatyana I. Kombarova, Ivan A. Dyatlov, Victoria V. Firstova   +7 more
doaj   +2 more sources

Cellular and systemic effects of anthrax lethal toxin and edema toxin [PDF]

Molecular Aspects of Medicine, 2009
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells.
Mahtab Moayeri, Stephen H Leppla
exaly   +3 more sources