Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. [PDF]
PLoS Pathogens, 2017 Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.
Sudarshan Seshadri +3 more
doaj +3 more sources
The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin [PDF]
EMBO Journal, 2019 Anthrax lethal toxin (LT) is known to induce NLRP1B inflammasome activation and pyroptotic cell death in macrophages from certain mouse strains in its metalloprotease activity‐dependent manner, but the underlying mechanism is unknown.
Jianjin Shi, Feng Shao, Na Dong
exaly +3 more sources
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system. [PDF]
MBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Stephen H. Leppla +2 more
exaly +4 more sources
Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]
PLoS ONE, 2013 Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen +11 more
doaj +3 more sources
Neutro"feels" lethal toxin. [PDF]
J Leukoc Biol, 2020 Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils.
Mazgaeen L, Gurung P.
europepmc +2 more sources
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. [PDF]
Cell, 2020 Pathogenic clostridial species secrete potent toxins that induce severe host tissue damage. Paeniclostridium sordellii lethal toxin (TcsL) causes an almost invariably lethal toxic shock syndrome associated with gynecological infections.
Lee H +11 more
europepmc +2 more sources
Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action [PDF]
ToxinsBacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva +7 more
doaj +2 more sources
BMC Medicine, 2012 Background Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications.
Kandadi Machender R +3 more
doaj +2 more sources
Anthrax lethal toxin suppresses murine cardiomyocyte contractile function and intracellular Ca2+ handling via a NADPH oxidase-dependent mechanism. [PDF]
PLoS ONE, 2010 OBJECTIVES: Anthrax infection is associated with devastating cardiovascular sequelae, suggesting unfavorable cardiovascular effects of toxins originated from Bacillus anthracis namely lethal and edema toxins. This study was designed to examine the direct
Machender R Kandadi +6 more
doaj +2 more sources
mSphere, 2016 Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin which glucosylates host GTPases to cause cytopathic and cytotoxic ...
Ryan Craven, D. Borden Lacy
doaj +2 more sources