Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]
PLoS ONE, 2013 Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen +11 more
doaj +5 more sources
Neutro"feels" lethal toxin. [PDF]
J Leukoc Biol, 2020 Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils.
Mazgaeen L, Gurung P.
europepmc +4 more sources
Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action [PDF]
ToxinsBacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva +7 more
doaj +2 more sources
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
doaj +6 more sources
Cellular and systemic effects of anthrax lethal toxin and edema toxin [PDF]
Molecular Aspects of Medicine, 2009 Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells.
Stephen Leppla, Mahtab Moayeri
exaly +3 more sources
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system [PDF]
mBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Jie Liu +5 more
doaj +2 more sources
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. [PDF]
PLoS Pathogens, 2017 Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.
Sudarshan Seshadri +3 more
doaj +2 more sources
Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B [PDF]
Toxins, 2016 Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the “Large clostridial glycosylating toxins.” These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by
Harald Genth, Ilona Schelle, Ingo Just
doaj +2 more sources
Anthrax Lethal Toxin-Induced Gene Expression Changes in Mouse Lung
Toxins, 2011 A major virulence factor of Bacillus anthracis is the anthrax Lethal Toxin (LeTx), a bipartite toxin composed of Protective Antigen and Lethal Factor. Systemic administration of LeTx to laboratory animals leads to death associated with vascular leakage ...
Igor Dozmorov +2 more
exaly +3 more sources
Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo.
PLoS Pathogens, 2008 The authors also acknowledge support for this work from National Institutes of Health grant AI48489.
Heather M Scobie +8 more
doaj +2 more sources