Results 21 to 30 of about 67,942 (278)
Sub-Lethal Dose of Shiga toxin 2 from Enterohemorrhagic Escherichia coli Affects Balance and Cerebellar Cythoarquitecture. [PDF]
Frontiers in Microbiology, 2016 Shiga toxin producing Escherichia coli may damage the central nervous system before or concomitantly to manifested hemolytic uremic syndrome symptoms.
Luciana eD’Alessio +6 more
doaj +2 more sources
Anthrax Lethal Toxin-Induced Gene Expression Changes in Mouse Lung
Toxins, 2011 A major virulence factor of Bacillus anthracis is the anthrax Lethal Toxin (LeTx), a bipartite toxin composed of Protective Antigen and Lethal Factor. Systemic administration of LeTx to laboratory animals leads to death associated with vascular leakage ...
A. Darise Farris +8 more
doaj +2 more sources
Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin
Toxins, 2010 Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White +2 more
doaj +3 more sources
Journal of Biological Chemistry, 1989 Anthrax lethal toxin consists of two separate proteins, protective antigen and lethal factor (LF). Certain macrophages and a mouse macrophage-like cell line, J774A.1, are lysed by low concentrations of lethal toxin. In contrast, another macrophage cell line, IC-21, and all other cell types tested were resistant to this toxin.
Y, Singh +3 more
core +4 more sources
Rational Drug Designing Strategies and Inhibitor Optimization: Anthrax Lethal Toxin Factor [PDF]
International Journal Bioautomation, 2012 Anthrax toxin protein protective antigen, edema factor and lethal factor are secreted by Bacillus anthracis bacteria causes several adverse effects on human as well as on ruminant animals and considered as serious biological weapons. Lethal toxin protein
Pawan Kumar Jayaswal +2 more
doaj +1 more source
The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin [PDF]
EMBO Journal, 2019 Jianjin Shi, Feng Shao, Na Dong
exaly +2 more sources
Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri +3 more
openaire +2 more sources
Scientific Reports, 2021 The advanced biomimetic mineralization technology was applied to protect the Botulinum neurotoxin type D, and the processing of the mineralization granule of botulinum toxin type D was successfully screened.
Shengqing Li +6 more
doaj +1 more source
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
doaj +1 more source
Induction of autophagy by anthrax lethal toxin [PDF]
Biochemical and Biophysical Research Communications, 2009 Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Yian Kim, Tan +5 more
openaire +2 more sources