Results 21 to 30 of about 988,812 (316)
Distinct regions of NLRP1B are required to respond to anthrax lethal toxin and metabolic inhibition. [PDF]
Infect Immun, 2014 Neiman-Zenevich J, Liao KC, Mogridge J.
europepmc +2 more sources
Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis [PDF]
Infection and Immunity, 2011 ABSTRACT Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
C. Ebrahimi +4 more
semanticscholar +3 more sources
Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri +3 more
openaire +2 more sources
Scientific Reports, 2021 The advanced biomimetic mineralization technology was applied to protect the Botulinum neurotoxin type D, and the processing of the mineralization granule of botulinum toxin type D was successfully screened.
Shengqing Li +6 more
doaj +1 more source
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol. [PDF]
PLoS ONE, 2008 Bacillus anthracis is the bacterium responsible for causing anthrax. The ability of B. anthracis to cause disease is dependent on a secreted virulence factor, lethal toxin, that promotes survival of the bacteria in the host by impairing the immune ...
Sarah Chapelsky +3 more
doaj +1 more source
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
doaj +1 more source
Induction of autophagy by anthrax lethal toxin [PDF]
Biochemical and Biophysical Research Communications, 2009 Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Yian Kim, Tan +5 more
openaire +2 more sources
A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]
PLoS ONE, 2011 Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu +3 more
doaj +1 more source
Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
doaj +1 more source
Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum [PDF]
Infection and Immunity, 1992 Clostridium septicum lethal (alpha-toxin) was purified and found to be a basic protein (pI 8.4) of approximately 48 kDa that is both lethal and hemolytic. The alpha-toxin had a hemolytic activity of approximately 2 x 10(7) hemolytic units per mg and a 50% lethal dose of approximately 10 micrograms/kg of body weight for mice.
J, Ballard +3 more
openaire +2 more sources