Results 11 to 20 of about 988,812 (316)
The Effects of Anthrax Lethal Toxin on Host Barrier Function [PDF]
Toxins, 2011 The pathological actions of anthrax toxin require the activities of its edema factor (EF) and lethal factor (LF) enzyme components, which gain intracellular access via its receptor-binding component, protective antigen (PA).
David M. Frucht, Roger D. Auth, Tao Xie
doaj +5 more sources
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
doaj +8 more sources
Cellular and systemic effects of anthrax lethal toxin and edema toxin [PDF]
Molecular Aspects of Medicine, 2009 Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease.
Stephen H. Leppla, Mahtab Moayeri
exaly +4 more sources
Purification of a Lethal Toxin of Edwardsiella tarda. [PDF]
Fish Pathology, 1996 A toxin lethal to fish was purified from extracellular products (ECP) of Edwardsiella tarda by ion exchange chromatography and gel filtration. The purified toxin is a protein having proteolytic activities and lethal toxicity to Japanese eel Anguilla japonica with the LD50 of 1.6μg per g of fish body weight. Molecular weight of the protein was estimated
Suprapto, Hari +3 more
core +5 more sources
Characterization of macrophage sensitivity and resistance to anthrax lethal toxin [PDF]
Infection and Immunity, 1993 Anthrax lethal toxin, which consists of two proteins, protective antigen and lethal factor, is cytolytic for macrophages. Macrophages from different mouse strains were found to vary in their sensitivities to toxin. C3H mouse macrophages lysed by lethal factor concentrations of 0.001 micrograms/ml were 100,000 times more sensitive than those from ...
A M, Friedlander +4 more
core +5 more sources
Toxins, 2011 Outbreaks of Bacillus anthracis in the US and Europe over the past 10 years have emphasized the health threat this lethal bacteria poses even for developed parts of the world.
Peter Q Eichacker +2 more
exaly +3 more sources
Anthrax toxin: a tripartite lethal combination.
FEBS letters, 2002 Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P +5 more
core +7 more sources
Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B [PDF]
Toxins, 2016 Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the “Large clostridial glycosylating toxins.” These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by
Harald Genth, Ilona Schelle, Ingo Just
doaj +2 more sources
Shiga toxin delivery in extracellular vesicles induces high mortality and severe kidney injury in a Gb3-dependent manner. [PDF]
PLoS PathogensEscherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury.
Markus Wendler +6 more
doaj +2 more sources
Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function
Infection and Immunity, 2012 S.4374-4387The lung is the site of entry for Bacillus anthracis in inhalation anthrax, the deadliest form of the disease. Bacillus anthracis produces virulence toxins required for disease.
Marybeth Langer +17 more
semanticscholar +2 more sources