Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol. [PDF]
PLoS ONE, 2008 Bacillus anthracis is the bacterium responsible for causing anthrax. The ability of B. anthracis to cause disease is dependent on a secreted virulence factor, lethal toxin, that promotes survival of the bacteria in the host by impairing the immune ...
Sarah Chapelsky +3 more
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BMC Medicine, 2012 Background Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications.
Kandadi Machender R +3 more
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A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]
PLoS ONE, 2011 Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu +3 more
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Purification of a Lethal Toxin of Edwardsiella tarda. [PDF]
Fish Pathology, 1996 A toxin lethal to fish was purified from extracellular products (ECP) of Edwardsiella tarda by ion exchange chromatography and gel filtration. The purified toxin is a protein having proteolytic activities and lethal toxicity to Japanese eel Anguilla japonica with the LD50 of 1.6μg per g of fish body weight. Molecular weight of the protein was estimated
Suprapto, Hari +3 more
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Characterization of macrophage sensitivity and resistance to anthrax lethal toxin [PDF]
Infection and Immunity, 1993 Anthrax lethal toxin, which consists of two proteins, protective antigen and lethal factor, is cytolytic for macrophages. Macrophages from different mouse strains were found to vary in their sensitivities to toxin. C3H mouse macrophages lysed by lethal factor concentrations of 0.001 micrograms/ml were 100,000 times more sensitive than those from ...
A M, Friedlander +4 more
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Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
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Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis [PDF]
Infection and Immunity, 2011 ABSTRACT Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
Celia M, Ebrahimi +4 more
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Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B [PDF]
Toxins, 2016 Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the “Large clostridial glycosylating toxins.” These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by
Harald Genth, Ilona Schelle, Ingo Just
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Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo.
PLoS Pathogens, 2008 The authors also acknowledge support for this work from National Institutes of Health grant AI48489.
Heather M Scobie +8 more
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Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome [PDF]
Frontiers in PharmacologyBackgroundShiga toxin-producing Escherichia coli is the main cause of post-diarrheal hemolytic uremic syndrome (HUS), which produces acute kidney injury mainly in children. Shiga toxin exerts its action by binding to the glycolipid globotriaosylceramide (
Daiana S. Sánchez +7 more
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