Results 11 to 20 of about 64,896 (248)
Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome [PDF]
Frontiers in PharmacologyBackgroundShiga toxin-producing Escherichia coli is the main cause of post-diarrheal hemolytic uremic syndrome (HUS), which produces acute kidney injury mainly in children. Shiga toxin exerts its action by binding to the glycolipid globotriaosylceramide (
Daiana S. Sánchez +7 more
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mSphere, 2016 Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin which glucosylates host GTPases to cause cytopathic and cytotoxic ...
Ryan Craven, D. Borden Lacy
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The Effects of Anthrax Lethal Toxin on Host Barrier Function
Toxins, 2011 The pathological actions of anthrax toxin require the activities of its edema factor (EF) and lethal factor (LF) enzyme components, which gain intracellular access via its receptor-binding component, protective antigen (PA).
David M Frucht, Frucht David M
exaly +3 more sources
The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin [PDF]
EMBO Journal, 2019 Jianjin Shi, Feng Shao, Na Dong
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Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri +3 more
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Scientific Reports, 2021 The advanced biomimetic mineralization technology was applied to protect the Botulinum neurotoxin type D, and the processing of the mineralization granule of botulinum toxin type D was successfully screened.
Shengqing Li +6 more
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Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol. [PDF]
PLoS ONE, 2008 Bacillus anthracis is the bacterium responsible for causing anthrax. The ability of B. anthracis to cause disease is dependent on a secreted virulence factor, lethal toxin, that promotes survival of the bacteria in the host by impairing the immune ...
Sarah Chapelsky +3 more
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Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
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Induction of autophagy by anthrax lethal toxin [PDF]
Biochemical and Biophysical Research Communications, 2009 Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Yian Kim, Tan +5 more
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A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]
PLoS ONE, 2011 Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu +3 more
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