Quantitative Determination of Lethal Toxin Proteins in Culture Supernatant of Human Live Anthrax Vaccine Bacillus anthracis A16R [PDF]
Toxins, 2016 Xiaodong Zai +2 more
exaly +2 more sources
Development of an in Vitro Potency Assay for Anti-anthrax Lethal Toxin Neutralizing Antibodies
Toxins, 2012 Lethal toxin (LT) of Bacillus anthracis reduces the production of a number of inflammatory mediators, including transcription factors, chemokines and cytokines in various human cell lines, leading to down-regulation of the host inflammatory response ...
Sjoerd Rijpkema +2 more
doaj +1 more source
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. [PDF]
PLoS Pathogens, 2010 Bacillus anthracis infects hosts as a spore, germinates, and disseminates in its vegetative form. Production of anthrax lethal and edema toxins following bacterial outgrowth results in host death.
Mahtab Moayeri +8 more
doaj +1 more source
Cells, 2021 Inhibition of the RAF-MEK1/2-ERK signaling pathway is an ideal strategy for treating cancers with NRAS or BRAF mutations. However, the development of resistance due to incomplete inhibition of the pathway and activation of compensatory cell proliferation
Soon-Duck Ha +3 more
doaj +1 more source
Anthrax lethal and edema toxins in anthrax pathogenesis [PDF]
Trends in Microbiology, 2014 The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B.
Shihui, Liu +2 more
openaire +2 more sources
The Receptors that Mediate the Direct Lethality of Anthrax Toxin [PDF]
Toxins, 2012 Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding. Recently, a cell-based analysis was used to implicate another vWA domain-containing protein, integrin β1 as
Stephen H. Leppla +3 more
openaire +3 more sources
Assay of Diphtheria Vaccine Potency by Intradermal Challenge Test
Эпидемиология и вакцинопрофилактика, 2023 Relevance. Modern identifying potency (immunogenicity) of diphtheria toxoid tests are based on determining immunized animals resistance for administration challenge toxin or evaluation of protective antibodies level in serum.
E. I. Komarovskaya, О. V. Perelygyna
doaj +1 more source
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin [PDF]
Infection and Immunity, 2007 ABSTRACT Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF and PA constitute edema toxin (ET), which causes edema when injected subcutaneously.
Aaron M, Firoved +5 more
openaire +2 more sources
The impact of glycopeptide- and methicillin- resistance on "Staphylococcus aureus" and its virulence in localized and systemic infections [PDF]
, 2007 Adaptation of bacteria to their environment is a necessity to keep their fitness and survival under limiting conditions. In chapter I of this work we demonstrated that adaptation of glycopeptide-resistant S.
Karaüzüm, Hatice
core +1 more source
Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]
, 2013 Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406) +39 more
core +1 more source