Nature Communications, 2020 Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host cell.
Nathan J. Hardenbrook +5 more
semanticscholar +1 more source
Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]
PLoS ONE, 2012 Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas +5 more
doaj +1 more source
A simple electroelution method for rapid protein purification: isolation and antibody production of alpha toxin from Clostridium septicum [PDF]
PeerJ, 2017 Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum ...
Lorena Vázquez-Iglesias +6 more
doaj +2 more sources
Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]
, 2012 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Maite +8 more
core +3 more sources
Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]
, 2013 Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger +24 more
core +2 more sources
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]
PLoS Pathogens, 2007 The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani +12 more
doaj +1 more source
Lethal toxin actions and their consequences [PDF]
Journal of Applied Microbiology, 1999 After entry of infectious anthrax spores into the body, host-specific signals induce spore germination, outgrowth of vegetative bacilli and the expression of lethal toxin and other virulence factors. Anthrax lethal toxin (LeTx) is a virulence factor responsible for the major pathologies seen during systemic anthrax infections. Injection of sterile LeTx
openaire +2 more sources
Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy +20 more
core +1 more source
Development of an in Vitro Potency Assay for Anti-anthrax Lethal Toxin Neutralizing Antibodies
Toxins, 2012 Lethal toxin (LT) of Bacillus anthracis reduces the production of a number of inflammatory mediators, including transcription factors, chemokines and cytokines in various human cell lines, leading to down-regulation of the host inflammatory response ...
Sjoerd Rijpkema +2 more
doaj +1 more source
The Receptors that Mediate the Direct Lethality of Anthrax Toxin [PDF]
Toxins, 2012 Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding. Recently, a cell-based analysis was used to implicate another vWA domain-containing protein, integrin β1 as
Stephen H. Leppla +3 more
openaire +3 more sources