Results 31 to 40 of about 142,050 (194)

A case of septicaemic anthrax in an intravenous drug user [PDF]

, 2011
<p><b>Background:</b> In 2000, Ringertz et al described the first case of systemic anthrax caused by injecting heroin contaminated with anthrax.
Joseph EM Crozier, David J Galloway, Hodgson, H., Galloway, D.J., Heather Hodgson, Arfon GMT Powell, Powell, A.G.M.T., Crozier, J.E.M.   +7 more
core   +2 more sources

Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. [PDF]

PLoS ONE, 2014
CMG2-Fc is a fusion protein composed of the extracellular domain of capillary morphogenesis protein 2 (CMG2) and the Fc region of human immunoglobulin G; CMG2-Fc neutralizes anthrax toxin and offers protection against Bacillus anthracis challenge.
Yongyi Xi, Xiaojie Wu, Lihua Gao, Yong Shao, Hui Peng, Hongxing Chen, Huipeng Chen, Xianwen Hu, Junjie Yue   +8 more
doaj   +1 more source

Dominant negative phenotype of Bacillus thuringiensis Cry1Ab, Cry11Aa and Cry4Ba mutants suggest hetero-oligomer formation among different Cry toxins. [PDF]

, 2011
Background - Bacillus thuringiensis Cry toxins are used worldwide in the control of different insect pests important in agriculture or in human health. The Cry proteins are pore-forming toxins that affect the midgut cell of target insects.
Leivi Portugal, Maagd, R.A., de, Daniela Carmona, Alejandra Bravo, Portugal, L., de Maagd, R.A., Bakker, P., Perez, C., Claudia Rodríguez-Almazán, Mario Soberón, Bravo, A., Rodriguez-Almazan, C., Carmona, D., Claudia Pérez, Soberon, M., Carlos Muñoz-Garay, Ruud A de Maagd, Munoz-Garay, C., Petra Bakker   +18 more
core   +1 more source

Designing inhibitors of anthrax toxin [PDF]

Expert Opinion on Drug Discovery, 2014
Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the ...
Ekaterina M, Nestorovich, Sergey M, Bezrukov   +1 more
openaire   +2 more sources

Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model.

PLoS Pathogens, 2022
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr   +11 more
doaj   +1 more source

Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [PDF]

, 2004
Background: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors.
Jiang, I., Ruther, P., Wang, F., Rebecca Nedellec, Nedellec, R, Nedellec, R., Wang, F, Paul Ruther, Jiang, I, Sun, SM, Sawada-Hirai, R, Sun, S.M., Fei Wang, Millis, D., Kang, A.S., Alejandro Alvarez, Phillip R Morrow, Diane Millis, Alvarez, A., Alvarez, A, Shu Sun, Angray S Kang, Morrow, P.R., Millis, D, Sawada-Hirai, R., Ivy Jiang, Morrow, PR, Ruther, P, Kang, AS, Ritsuko Sawada-Hirai   +29 more
core   +1 more source

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes. [PDF]

Proc Natl Acad Sci U S A, 2019
The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins.
Sergeeva OA, van der Goot FG.
europepmc   +3 more sources

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]

PLoS Pathogens, 2007
Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery, Nicholas S Duesbery   +8 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes.

PLoS ONE, 2020
Understanding immune responses to native antigens in response to natural infections can lead to improved approaches to vaccination. This study sought to characterize the humoral immune response to anthrax toxin components, capsule and spore antigens in ...
Eric K Dumas, Hayati Demiraslan, Rebecca J Ingram, Rebecca M Sparks, Emily Muns, Adriana Zamora, Jason Larabee, Lori Garman, Jimmy D Ballard, Geert-Jan Boons, Judith A James, Uner Kayabas, Mehmet Doganay, A Darise Farris   +13 more
doaj   +1 more source