Results 31 to 40 of about 10,314 (165)

Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function. [PDF]

PLoS ONE, 2010
Cell-surface receptors play essential roles in anthrax toxin action by providing the toxin with a high-affinity anchor and self-assembly site on the plasma membrane, mediating the toxin entry into cells through endocytosis, and shifting the pH threshold ...
Jianjun Sun, R John Collier
doaj   +1 more source

Anthrax Toxin: A Pioneer of Targeted Protein Toxins. [PDF]

Toxins (Basel)
With anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells.
Richter S, Schmidt G.
europepmc   +2 more sources

Anthrax toxin rafts into cells [PDF]

, 2003
Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al.
Kurzchalia, T.
core   +2 more sources

Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein. [PDF]

PLoS ONE, 2009
BACKGROUND:To initiate infection, Bacillus anthracis needs to overcome the host innate immune system. Anthrax toxin, a major virulence factor of B. anthracis, impairs both the innate and adaptive immune systems and is important in the establishment of ...
Haijing Hu, Stephen H Leppla
doaj   +1 more source

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger, Anika Bronnhuber, Benz, Roland, Hajós György, Markus Huber-Lang, Hajós, György, Kerstin Duscha, Riedl Zsuzsanna, Beitzinger, Christoph, Riedl, Zsuzsanna, Duscha Kerstin, György Hajós, Huber-Lang Markus, Beitzinger Christoph, Barth Holger, Duscha, Kerstin, Bronnhuber, Annika, Benz Roland, Christoph Beitzinger, Roland Benz, Holger Barth, Bronnhuber Anika, Bronnhuber, Anika, Huber-Lang, Markus, Zsuzsanna Riedl   +24 more
core   +1 more source

Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression

Toxins, 2015
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility.
Zhang Zhang, Yan Zhang, Minglei Shi, Bingyu Ye, Wenlong Shen, Ping Li, Lingyue Xing, Xiaopeng Zhang, Lihua Hou, Junjie Xu, Zhihu Zhao, Wei Chen   +11 more
doaj   +1 more source

Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [PDF]

, 2004
Background: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors.
Jiang, I., Ruther, P., Wang, F., Rebecca Nedellec, Nedellec, R, Nedellec, R., Wang, F, Paul Ruther, Jiang, I, Sun, SM, Sawada-Hirai, R, Sun, S.M., Fei Wang, Millis, D., Kang, A.S., Alejandro Alvarez, Phillip R Morrow, Diane Millis, Alvarez, A., Alvarez, A, Shu Sun, Angray S Kang, Morrow, P.R., Millis, D, Sawada-Hirai, R., Ivy Jiang, Morrow, PR, Ruther, P, Kang, AS, Ritsuko Sawada-Hirai   +29 more
core   +1 more source

Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. [PDF]

PLoS ONE, 2014
CMG2-Fc is a fusion protein composed of the extracellular domain of capillary morphogenesis protein 2 (CMG2) and the Fc region of human immunoglobulin G; CMG2-Fc neutralizes anthrax toxin and offers protection against Bacillus anthracis challenge.
Yongyi Xi, Xiaojie Wu, Lihua Gao, Yong Shao, Hui Peng, Hongxing Chen, Huipeng Chen, Xianwen Hu, Junjie Yue   +8 more
doaj   +1 more source

Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model.

PLoS Pathogens, 2022
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr   +11 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source