Results 31 to 40 of about 8,844 (171)

Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis [PDF]

PeerJ, 2019
The anthrax toxin is a virulence factor produced by the bacterium Bacillus anthracis. Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of B.
Kochi Toyomane, Yoshikazu Furuta, Daisuke Fujikura, Hideaki Higashi   +3 more
doaj   +2 more sources

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes.

PLoS ONE, 2020
Understanding immune responses to native antigens in response to natural infections can lead to improved approaches to vaccination. This study sought to characterize the humoral immune response to anthrax toxin components, capsule and spore antigens in ...
Eric K Dumas, Hayati Demiraslan, Rebecca J Ingram, Rebecca M Sparks, Emily Muns, Adriana Zamora, Jason Larabee, Lori Garman, Jimmy D Ballard, Geert-Jan Boons, Judith A James, Uner Kayabas, Mehmet Doganay, A Darise Farris   +13 more
doaj   +1 more source

Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis.

PLoS Neglected Tropical Diseases, 2019
Bacillus anthracis and Yersinia pestis are zoonotic bacteria capable of causing severe and sometimes fatal infections in animals and humans. Although considered as diseases of antiquity in industrialized countries due to animal and public health ...
Theresa B Gallagher, Gabriela Mellado-Sanchez, Ana L Jorgensen, Stephen Moore, James P Nataro, Marcela F Pasetti, Les W Baillie   +6 more
doaj   +1 more source

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

Frontiers in Cellular and Infection Microbiology, 2018
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu, Syed R. Ali, Ethan Bier, Victor Nizet, Victor Nizet   +4 more
doaj   +1 more source

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

Toxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse, Xizhong Cui, Yan Li, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker   +5 more
doaj   +1 more source

Anthrax toxin rafts into cells [PDF]

The Journal of Cell Biology, 2003
Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin ...
openaire   +3 more sources

Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1 [PDF]

Clinical and Experimental Immunology, 2013
Summary Anthrax is a toxin-mediated disease, the lethal effects of which are initiated by the binding of protective antigen (PA) with one of three reported cell surface toxin receptors (ANTXR). Receptor binding has been shown to influence host susceptibility to the toxins.
Ingram RJ, Harris A, Ascough S, Metan G, Doganay M, Ballie L, Williamson ED, Dyson H, Robinson JH, Sriskandan S, Altmann DM   +10 more
openaire   +5 more sources

A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis

Scientific Reports, 2018
Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder, Shreya Das, Vikas Somani, Shivakiran S. Makam, Kingston J. Joseph, Rakesh Bhatnagar   +5 more
doaj   +1 more source

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. [PDF]

PLoS ONE, 2011
Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells.
Angelika Kronhardt, Monica Rolando, Christoph Beitzinger, Caroline Stefani, Michael Leuber, Gilles Flatau, Michel R Popoff, Roland Benz, Emmanuel Lemichez   +8 more
doaj   +1 more source

Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells [PDF]

Molecular Microbiology, 2006
Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by a third factor, protective antigen (PA), which binds ...
Francisco J, Maldonado-Arocho, Jennifer A, Fulcher, Benhur, Lee, Kenneth A, Bradley   +3 more
openaire   +2 more sources