Results 31 to 40 of about 19,232 (195)

Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model.

PLoS Pathogens, 2022
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr   +11 more
doaj   +1 more source

Designing inhibitors of anthrax toxin [PDF]

Expert Opinion on Drug Discovery, 2014
Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the ...
Ekaterina M, Nestorovich, Sergey M, Bezrukov   +1 more
openaire   +2 more sources

Rapid Targeted Gene Disruption in Bacillus Anthracis [PDF]

, 2013
Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen.
Ellington, Andrew, Kramer, Ryan, Lambowitz, Alan M., Lamkin, Thomas J., Pemberton, Adin, Perutka, Jiri, Saldanha, Roland J., Shiflett, Patrick, Taylor, Deborah, Whitt, Jacob T.   +9 more
core   +3 more sources

Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells [PDF]

Molecular Microbiology, 2006
Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by a third factor, protective antigen (PA), which binds ...
Francisco J, Maldonado-Arocho, Jennifer A, Fulcher, Benhur, Lee, Kenneth A, Bradley   +3 more
openaire   +2 more sources

Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1 [PDF]

Clinical and Experimental Immunology, 2013
Summary Anthrax is a toxin-mediated disease, the lethal effects of which are initiated by the binding of protective antigen (PA) with one of three reported cell surface toxin receptors (ANTXR). Receptor binding has been shown to influence host susceptibility to the toxins.
Ingram RJ, Harris A, Ascough S, Metan G, Doganay M, Ballie L, Williamson ED, Dyson H, Robinson JH, Sriskandan S, Altmann DM   +10 more
openaire   +5 more sources

The Receptors that Mediate the Direct Lethality of Anthrax Toxin

Toxins, 2012
Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding ...
Stephen H. Leppla, Benjamin Hoover, Yi Zhang, Shihui Liu   +3 more
doaj   +1 more source

Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]

PLoS Pathogens, 2006
Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G Jonah A Rainey, D Borden Lacy, Marianne Manchester, R John Collier, John A T Young   +8 more
doaj   +1 more source

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes.

PLoS ONE, 2020
Understanding immune responses to native antigens in response to natural infections can lead to improved approaches to vaccination. This study sought to characterize the humoral immune response to anthrax toxin components, capsule and spore antigens in ...
Eric K Dumas, Hayati Demiraslan, Rebecca J Ingram, Rebecca M Sparks, Emily Muns, Adriana Zamora, Jason Larabee, Lori Garman, Jimmy D Ballard, Geert-Jan Boons, Judith A James, Uner Kayabas, Mehmet Doganay, A Darise Farris   +13 more
doaj   +1 more source

Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis [PDF]

PeerJ, 2019
The anthrax toxin is a virulence factor produced by the bacterium Bacillus anthracis. Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of B.
Kochi Toyomane, Yoshikazu Furuta, Daisuke Fujikura, Hideaki Higashi   +3 more
doaj   +2 more sources

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source