Results 11 to 20 of about 142,050 (194)
Anthrax Toxin Characterization [PDF]
Acta Medica, 2002 The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled.
Jiří Patočka, Miroslav Špliňo
doaj +4 more sources
Anthrax toxin rafts into cells [PDF]
The Journal of Cell Biology, 2003 Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al.
Teymuras Kurzchalia, Kurzchalia, T.
core +6 more sources
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
Toxins, 2016 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li +8 more
doaj +2 more sources
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
doaj +3 more sources
Tumor Targeting and Drug Delivery by Anthrax Toxin
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
doaj +2 more sources
The Receptors that Mediate the Direct Lethality of Anthrax Toxin
Toxins, 2012 Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding ...
Stephen H. Leppla +3 more
doaj +2 more sources
Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1 [PDF]
Clinical and Experimental Immunology, 2013 Anthrax is a toxin-mediated disease, the lethal effects of which are initiated by the binding of protective antigen (PA) with one of three reported cell surface toxin receptors (ANTXR).
Ballie, Les +26 more
core +8 more sources
'Panorama's coverage of 9-11 and the war on terror'’ [PDF]
, 2010 The BBC's 'flagship' current affairs series Panorama backed away from reporting on the 9-11 attacks despite having a senior reporter with relevant expertise in the area.
McQueen, David
core +9 more sources
Anthrax Toxin: A Pioneer of Targeted Protein Toxins. [PDF]
Toxins (Basel)With anthrax toxin as a pioneer, several bacterial toxins have been engineered to deliver proteins of interest into the cytosol of specific mammalian cells. Such targeted protein toxins combine the ability to deliver cargo molecules into cells with designed receptor interaction for targeting selected cells.
Richter S, Schmidt G.
europepmc +3 more sources
Pathogens, 2022 Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876―when Robert Koch demonstrated that Bacillus anthracis caused anthrax―it has been ...
William A. Bower +6 more
doaj +1 more source