Tumor Targeting and Drug Delivery by Anthrax Toxin [PDF]
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
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BMC Biotechnology, 2011 Background Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the tripartite toxin complex, composed of the receptor-binding anthrax protective antigen ...
Andersen Kasper +4 more
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Anthrax toxin component, Protective Antigen, protects insects from bacterial infections. [PDF]
PLoS Pathogens, 2020 Anthrax is a major zoonotic disease of wildlife, and in places like West Africa, it can be caused by Bacillus anthracis in arid nonsylvatic savannahs, and by B. cereus biovar anthracis (Bcbva) in sylvatic rainforests.
Saleem Alameh +11 more
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Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore [PDF]
Microbial Pathogenesis, 2007 We used quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A.1 macrophage cells and different tissues of mice, but also evaluate the effect of anthrax edema toxin and Bacillus anthracis Sterne spores on the expression of mRNA of these receptors.
Qingfu, Xu, Eric D, Hesek, Mingtao, Zeng
exaly +3 more sources
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system
MBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Jie Liu, Zehua Zuo, Toren Finkel
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Pathogens, 2022 Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876―when Robert Koch demonstrated that Bacillus anthracis caused anthrax―it has been ...
William A. Bower +6 more
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Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors. [PDF]
PLoS ONE, 2011 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. The toxin consists of three protein subunits: protective antigen (PA), lethal factor, and edema factor.
Chenguang Cai +8 more
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Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. [PDF]
, 2017 Anthrax toxin receptor-mediated drug development for blocking anthrax toxin action has received much attention in recent decades. In this study, we produced a secreted anthrax decoy fusion protein comprised of a portion of the human capillary ...
Dandekar, Abhaya M +8 more
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Evidence against a human cell-specific role for LRP6 in anthrax toxin entry. [PDF]
PLoS ONE, 2008 The role of the cellular protein LRP6 in anthrax toxin entry is controversial. Previous studies showed that LRP6 was important for efficient intoxication of human M2182 prostate carcinoma cells but other studies performed with cells from gene-knockout ...
Patricia L Ryan, John A T Young
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A Comparison of the Adaptive Immune Response between Recovered Anthrax Patients and Individuals Receiving Three Different Anthrax Vaccines. [PDF]
PLoS ONE, 2016 Several different human vaccines are available to protect against anthrax. We compared the human adaptive immune responses generated by three different anthrax vaccines or by previous exposure to cutaneous anthrax.
Thomas R Laws +14 more
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