Medical Countermeasures against Ricin Intoxication
Toxins, 2023 Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil +1 more
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AB 5 Preassembly Is Not Required for Shiga Toxin Activity [PDF]
Journal of Bacteriology, 2016 ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of foodborne illness, including the life-threatening complication hemolytic-uremic syndrome. The German outbreak in 2011 resulted in nearly 4,000 cases of infection, with 54 deaths.
Christine A, Pellino +3 more
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Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being
Toxins, 2014 Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their toxins include Clostridium botulinum (C2 toxin), Clostridium difficile (
Bradley G. Stiles +5 more
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Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin
Toxins, 2021 Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor.
Carolin Kling +3 more
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Constitutive expression of Vr-ERE gene in transformed grapevines confers enhanced resistance to eutypine, a toxin from Eutypa lata [PDF]
, 2003 Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata , the causal agent of eutypa dieback of grapevines.
Bouquet, Alain +23 more
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Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations
Toxins, 2017 The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Amram Torgeman +9 more
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Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle [PDF]
, 2013 Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely +4 more
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Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]
, 2012 Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050) +21 more
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Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome [PDF]
, 2010 Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection
Mayer, Margit E. +15 more
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Purification and some properties of Clostridium botulinum type AB toxin [PDF]
FEMS Microbiology Letters, 1986 Abstract The progenitor toxin of Clostridium botulinum type AB was purified; both large-sized (L) and medium-sized (M) toxins were found. The toxicity of M toxin increased by about 10-fold upon trypsinization; the increase was due mostly to type B toxin and a little to type A toxin.
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