The History of Pertussis Toxin [PDF]
Toxins, 2021 Besides the typical whooping cough syndrome, infection with Bordetella pertussis or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization,
Camille Locht, Rudy Antoine
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Pertussis Toxin: A Key Component in Pertussis Vaccines? [PDF]
Toxins, 2019 B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The ongoing resurgence in pertussis incidence in high income countries is likely due to faster waning of immunity and increased asymptomatic colonization in individuals ...
Kelsey A. Gregg, Tod J. Merkel
exaly +7 more sources
Association of Pertussis Toxin with Severe Pertussis Disease [PDF]
Toxins, 2019 Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have
Karen M Scanlon, Ciaran Skerry
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A novel vaccine formulation candidate based on lipooligosaccharides and pertussis toxin against Bordetella pertussis [PDF]
Frontiers in Immunology, 2023 Pertussis is a severe human respiratory tract infectious disease caused by Bordetella pertussis that primarily affects infants and young children.
Jingjing Gao +6 more
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Avidity of pertussis toxin antibodies following vaccination with genetically versus chemically detoxified pertussis toxin-containing vaccines during pregnancy [PDF]
Frontiers in ImmunologyBackgroundBoth the quantity and quality of circulating anti-pertussis toxin antibodies are important for protection against severe pertussis. We compared the avidity of PT-IgG antibodies in pregnant women and their infants following vaccination during ...
Bahaa Abu-Raya +8 more
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OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz [PDF]
Communications Biology, 2022 A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.
Alastair C. Keen +11 more
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The Chaperonin TRiC/CCT Inhibitor HSF1A Protects Cells from Intoxication with Pertussis Toxin [PDF]
ToxinsPertussis toxin (PT) is a bacterial AB5-toxin produced by Bordetella pertussis and a major molecular determinant of pertussis, also known as whooping cough, a highly contagious respiratory disease.
Jinfang Jia +4 more
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Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis [PDF]
ToxinsPertussis toxin (PTx) is a major virulence factor of Bordetella pertussis and an AB5-type exotoxin that disrupts host signaling. Its enzymatic A subunit ADP-ribosylates the α-subunit of inhibitory G proteins (Gαi), preventing them from mediating receptor-
Qing Tang +3 more
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Vaccines, 2021 Pertussis is an acute respiratory tract infection caused by Bordetella pertussis. Even though its current vaccine coverage is relatively broad, they still have some shortcomings such as short protection time and might be incapable of blocking the spread ...
Han Xu +10 more
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New combination of methods for isolation and purification of pertussis toxin from the Bordetella pertussis culture [PDF]
Hemijska Industrija, 2011 In this paper a method for isolation and purification of the pertussis toxin from the cell culture of Bordetella pertussis was presented. Pertussis toxin production was enhanced with the optimization of the microbiological media and cultivation time ...
Pavlović Katarina B. +1 more
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