Results 11 to 20 of about 51,446 (212)
Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin [PDF]
Emerging Infectious Diseases, 2016 A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013.
Margaret M. Williams +6 more
doaj +3 more sources
Secretion of Pertussis Toxin from Bordetella pertussis. [PDF]
Toxins (Basel), 2021 Production and secretion of pertussis toxin (PT) is essential for the virulence of Bordetella pertussis. Due to the large oligomeric structure of PT, transport of the toxin across bacterial membrane barriers represents a significant hurdle that the bacteria must overcome in order to maintain pathogenicity.
Burns DL.
europepmc +5 more sources
Novel Strategies to Inhibit Pertussis Toxin. [PDF]
Toxins (Basel), 2022 Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT). The characteristic symptom is severe, long-lasting paroxysmal coughing.
Ernst K.
europepmc +6 more sources
Promoter of the pertussis toxin operon and production of pertussis toxin [PDF]
Journal of Bacteriology, 1987 Pertussis toxin (PT), the major virulence factor of Bordetella pertussis, is composed of five different subunits whose genes are organized as an operon. We report the mapping of the promoter region of the PT operon and show that this promoter is only weakly active in Escherichia coli. Bordetella parapertussis and Bordetella bronchiseptica, which do not
NICOSIA, Alfredo, R. RAPPUOLI
openaire +3 more sources
Genetics of pertussis toxin [PDF]
Molecular Microbiology, 1989 SummaryPertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and
R, Gross, B, Aricò, R, Rappuoli
openaire +2 more sources
mBio, 2020 Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya +13 more
doaj +1 more source
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
doaj +1 more source
Evaluation of Pertussis Toxin Expression in B2 and THIJS Media [PDF]
Archives of Razi Institute, 2019 Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi
H. Moradtalab +3 more
doaj +1 more source
Неонатологія, хірургія та перинатальна медицина, 2023 Coronavirus disease remains one of the most serious diseases in the world. The percentage of severe and fatal cases in children is lower than in adults. The search for biomarkers of disease severity continues.
Г. Павлишин +2 more
doaj +1 more source
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source