Results 11 to 20 of about 166,888 (204)
Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin [PDF]
Emerging Infectious Diseases, 2016 A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013.
Margaret M. Williams +6 more
doaj +4 more sources
MODERNIZATION OF GENEOTIPING OF STRAINS B. PERTUSSIS [PDF]
Детские инфекции (Москва), 2015 The new rapid molecular genotyping method was developed for studying the structure of ptxP promoter of pertussis toxin. Method is based on PCR-RFLP analysis, which allows studying the specific restriction profiles of the B.
G. A. Ivashinnikova +4 more
doaj +3 more sources
Human Vaccines & Immunotherapeutics, 2019 Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade ...
Naveen Surendran, Michael Pichichero
doaj +2 more sources
Novel Strategies to Inhibit Pertussis Toxin. [PDF]
Toxins (Basel), 2022 Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT). The characteristic symptom is severe, long-lasting paroxysmal coughing.
Ernst K.
europepmc +7 more sources
Infection and Immunity, 1996 The DNA sequence of the pertussis toxin operon (ptx) of Bordetella pertussis predicts that transcription of the operon ends downstream from the ptxS3 gene at a possible stem-loop structure. Secretion of the assembled pertussis toxin into the culture medium required the expression of 8 genes arranged in an operon (ptl) and lying 55 bp downstream from ...
Ricci S., Rappuoli R., Scarlato V.
openaire +4 more sources
Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence [PDF]
Emerging Infectious Diseases, 2009 Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread vaccination of children succeeded in reducing illness and death.
Frits R. Mooi +10 more
doaj +3 more sources
Promoter of the pertussis toxin operon and production of pertussis toxin [PDF]
Journal of Bacteriology, 1987 Pertussis toxin (PT), the major virulence factor of Bordetella pertussis, is composed of five different subunits whose genes are organized as an operon. We report the mapping of the promoter region of the PT operon and show that this promoter is only weakly active in Escherichia coli. Bordetella parapertussis and Bordetella bronchiseptica, which do not
NICOSIA, Alfredo, R. RAPPUOLI
openaire +4 more sources
Secretion of Pertussis Toxin from Bordetella pertussis. [PDF]
Toxins (Basel), 2021 Production and secretion of pertussis toxin (PT) is essential for the virulence of Bordetella pertussis. Due to the large oligomeric structure of PT, transport of the toxin across bacterial membrane barriers represents a significant hurdle that the bacteria must overcome in order to maintain pathogenicity.
Burns DL.
europepmc +5 more sources
Genetics of pertussis toxin [PDF]
Molecular Microbiology, 1989 SummaryPertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and
R, Gross, B, Aricò, R, Rappuoli
openaire +2 more sources
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
doaj +1 more source