Results 41 to 50 of about 33,335 (199)

Lectinlike properties of pertussis toxin [PDF]

Infection and Immunity, 1989
We have examined the lectinlike properties of pertussis toxin by binding-inhibition assays and affinity chromatography of goose erythrocyte membranes. Although pertussis toxin and wheat germ agglutinin apparently recognize similar sugar sequences on glycoproteins, the binding activities of the two lectins are not identical.
G J, Tyrrell, M S, Peppler, R A, Bonnah, C G, Clark, P, Chong, G D, Armstrong   +5 more
openaire   +2 more sources

Lymphocyte receptors for pertussis toxin [PDF]

Infection and Immunity, 1990
We have investigated human T-lymphocyte receptors for pertussis toxin by affinity isolation and photoaffinity labeling procedures. T lymphocytes were obtained from peripheral human blood, surface iodinated, and solubilized in Triton X-100. The iodinated mixture was then passed through pertussis toxin-agarose, and the fractions were analyzed by sodium ...
C G, Clark, G D, Armstrong
openaire   +2 more sources

Does Breastfeeding Protect Young Infants from Pertussis? Case-Control Study and Immunologic Evaluation [PDF]

, 2017
Background: Pertussis infection can be severe in unvaccinated infants. A case-control study was conducted to investigate the potential role of breast-feeding in protecting young, unvaccinated infants from pertussis.
Carsetti Rita, Pandolfi Elisabetta, Villani A, Pertussis Study Group, Midulla Fabio, Carloni E, Fedele G, Fedele Giorgio, Stefanelli Paola, Tozzi Alberto Eugenio, Pandolfi E, MIDULLA, Fabio, Stefanelli P, Gesualdo F, Tozzi AE, Carsetti R, Carloni Emanuela, Gesualdo Francesco   +17 more
core   +1 more source

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

Nature Communications, 2016
Pertussis toxin enhances the induction of autoreactive T cells in mouse models of autoimmunity. Here the authors show that stimulation of IL-1β production in myeloid cells by pertussis toxin is necessary to prime pathogenic Th1/Th17 cells in experimental
Francesca Ronchi, Camilla Basso, Silvia Preite, Andrea Reboldi, Dirk Baumjohann, Luana Perlini, Antonio Lanzavecchia, Federica Sallusto   +7 more
doaj   +1 more source

Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections [PDF]

Infection and Immunity, 1984
Antibody-producing hybridomas of myeloma SP2/O and spleen cells of BALB/c mouse immunized with pertussis toxoid and pertussis toxin were selected by the binding ability of the monoclonal antibody to the subunit protein of the toxin. Two monoclonal antibodies, 1B7 and 3F10, specific for a subunit which has no binding activity to haptoglobin and sheep ...
H, Sato, A, Ito, J, Chiba, Y, Sato
openaire   +2 more sources

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Membrane Localization of the S1 Subunit of Pertussis Toxin in Bordetella pertussis and Implications for Pertussis Toxin Secretion [PDF]

Infection and Immunity, 2002
ABSTRACT Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of ...
Karen M, Farizo, Stefanie, Fiddner, Anissa M, Cheung, Drusilla L, Burns   +3 more
openaire   +2 more sources

Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. pertussis with age. [PDF]

PLoS ONE, 2013
Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective immunity against pertussis.
Wanda G H Han, Inonge van Twillert, Martien C M Poelen, Kina Helm, Jan van de Kassteele, Theo J M Verheij, Florens G A Versteegh, Claire J P Boog, Cécile A C M van Els   +8 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function. [PDF]

PLoS ONE, 2015
Whooping cough due to Bordetella pertussis is increasing in incidence, in part due to accumulation of mutations which increase bacterial fitness in highly vaccinated populations.
Scott H Millen, Mineo Watanabe, Eiji Komatsu, Fuminori Yamaguchi, Yuki Nagasawa, Eri Suzuki, Haleigh Monaco, Alison A Weiss   +7 more
doaj   +1 more source