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Pertussis in Lao PDR: Seroprevalence and disease [PDF]
, 2020 Objectives Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations.
Chanthavilay, Phetsavanh +9 more
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Frontiers in Microbiology, 2023 Pertussis, commonly known as whooping cough is a severe respiratory disease caused by the bacterium, Bordetella pertussis. Despite widespread vaccination, pertussis resurgence has been observed globally.
Hiroki Suyama +4 more
doaj +1 more source
The ins and outs of pertussis toxin [PDF]
The FEBS Journal, 2011 Pertussis toxin, produced and secreted by the whooping cough agentBordetella pertussis, is one of the most complex soluble bacterial proteins. It is actively secreted through theB. pertussiscell envelope by the Ptl secretion system, a member of the widespread type IV secretion systems. The toxin is composed of five subunits (named S1 to S5 according to
Camille, Locht +2 more
openaire +2 more sources
BMC Infectious Diseases, 2006 Background In Australia two acellular Bordetella pertussis vaccines have replaced the use of a whole cell vaccine. Both of the licensed acellular vaccines contain the following three components; pertussis toxoid, pertussis filamentous haemagglutinin and ...
Slack Andrew T, Byrne Shane
doaj +1 more source
Lectinlike properties of pertussis toxin [PDF]
Infection and Immunity, 1989 We have examined the lectinlike properties of pertussis toxin by binding-inhibition assays and affinity chromatography of goose erythrocyte membranes. Although pertussis toxin and wheat germ agglutinin apparently recognize similar sugar sequences on glycoproteins, the binding activities of the two lectins are not identical.
G J, Tyrrell +5 more
openaire +2 more sources
Lymphocyte receptors for pertussis toxin [PDF]
Infection and Immunity, 1990 We have investigated human T-lymphocyte receptors for pertussis toxin by affinity isolation and photoaffinity labeling procedures. T lymphocytes were obtained from peripheral human blood, surface iodinated, and solubilized in Triton X-100. The iodinated mixture was then passed through pertussis toxin-agarose, and the fractions were analyzed by sodium ...
C G, Clark, G D, Armstrong
openaire +2 more sources
Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections [PDF]
Infection and Immunity, 1984 Antibody-producing hybridomas of myeloma SP2/O and spleen cells of BALB/c mouse immunized with pertussis toxoid and pertussis toxin were selected by the binding ability of the monoclonal antibody to the subunit protein of the toxin. Two monoclonal antibodies, 1B7 and 3F10, specific for a subunit which has no binding activity to haptoglobin and sheep ...
H, Sato, A, Ito, J, Chiba, Y, Sato
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The actions of Pasteurella multocida toxin on neuronal cells
, 2014 Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid +13 more
core +1 more source
Membrane Localization of the S1 Subunit of Pertussis Toxin in Bordetella pertussis and Implications for Pertussis Toxin Secretion [PDF]
Infection and Immunity, 2002 ABSTRACT Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of ...
Karen M, Farizo +3 more
openaire +2 more sources
, 2008 The immunogenicity and protective efficacy of a DNA vaccine encoding a genetically inactivated S1 domain of pertussis toxin was evaluated using a murine respiratory challenge model of Bordetella pertussis infection.
Trilochan K. S. Mukkur +7 more
core +1 more source