Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host
Virulence, 2021 The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica.
Thomas Belcher +2 more
exaly +3 more sources
The Type III Secreted Protein BspR Regulates the Virulence Genes in Bordetella bronchiseptica [PDF]
PLoS ONE, 2012 Bordetella bronchiseptica is closely related with B. pertussis and B. parapertussis, the causative agents of whooping cough. These pathogenic species share a number of virulence genes, including the gene locus for the type III secretion system (T3SS ...
Jun Kurushima, Asaomi Kuwae, Akio Abe
exaly +3 more sources
Interplay of virulence factors and signaling molecules: albumin and calcium-mediated biofilm regulation in Bordetella bronchiseptica [PDF]
Journal of BacteriologyBordetella bronchiseptica, a respiratory pathogen capable of infecting various mammals, including humans, is associated with chronic infections. B.
Sabrina Laura Mugni +4 more
doaj +4 more sources
Identification of a CO2 responsive regulon in Bordetella. [PDF]
PLoS ONE, 2012 Sensing the environment allows pathogenic bacteria to coordinately regulate gene expression to maximize survival within or outside of a host. Here we show that Bordetella species regulate virulence factor expression in response to carbon dioxide levels ...
Sara E Hester +4 more
doaj +2 more sources
Released palmitic acid–mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage [PDF]
Nature CommunicationsWhooping cough has resurged globally despite high vaccination coverage. In China, a macrolide-resistant (MR) Bordetella pertussis lineage carrying the high-virulence ptxP3 allele, termed ptxP3 MR-MT28 (MT28), has been increasingly reported as a ...
Shuangshuang Li +17 more
doaj +2 more sources
Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species [PDF]
mBioBordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber +5 more
doaj +2 more sources
Virulence factor secretion and translocation by Bordetella species [PDF]
Current Opinion in Microbiology, 2009 Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional ...
Ruchi, Shrivastava, Jeff F, Miller
openaire +2 more sources
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. [PDF]
PLoS ONE, 2017 The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS.
Alex Rivera-Millot +10 more
doaj +1 more source
Frontiers in Microbiology, 2022 When bacteria sense cues from the host environment, stress responses are activated. Two component systems, sigma factors, small RNAs, ppGpp stringent response, and chaperones start coordinate the expression of virulence factors or immunomodulators to ...
Alina M. Holban +3 more
doaj +1 more source
mSystems, 2020 The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P).
Jakub Novák +11 more
doaj +1 more source