Results 1 to 10 of about 8,004 (115)

The Type III Secreted Protein BspR Regulates the Virulence Genes in Bordetella bronchiseptica [PDF]

PLoS ONE, 2012
Bordetella bronchiseptica is closely related with B. pertussis and B. parapertussis, the causative agents of whooping cough. These pathogenic species share a number of virulence genes, including the gene locus for the type III secretion system (T3SS ...
Asaomi Kuwae, Akio Abe, Jun Kurushima
exaly   +2 more sources

The role of cytochrome oxidases in bacterial virulence [PDF]

Infection and Immunity
Bacterial physiology plays an important role in virulence. Being a pathogen is energetically expensive, requiring the production of specialized virulence factors and other proteins that enable survival within the host. The most efficient way for bacteria
Liliana S. McKay, Andrew Camilli, Peggy A. Cotter   +2 more
doaj   +2 more sources

Released palmitic acid–mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage [PDF]

Nature Communications
Whooping cough has resurged globally despite high vaccination coverage. In China, a macrolide-resistant (MR) Bordetella pertussis lineage carrying the high-virulence ptxP3 allele, termed ptxP3 MR-MT28 (MT28), has been increasingly reported as a ...
Shuangshuang Li, Mingliang Chen, Xudong Feng, Yuquan Gao, Xuan Hong, Nadira Nurxat, Tianchi Chen, Guoxiu Xiang, Ziyu Yang, Ying Jian, Qing Wei, Bisheng Shi, Xiaowei Ma, Yanming Lu, Zhen Shen, Muyun Wei, Lei He, Min Li   +17 more
doaj   +2 more sources

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

Virulence, 2021
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica.
Thomas Belcher, Violaine Dubois, Alex Rivera-Millot, Camille Locht, Françoise Jacob-Dubuisson   +4 more
doaj   +1 more source

Identification of a CO2 responsive regulon in Bordetella. [PDF]

PLoS ONE, 2012
Sensing the environment allows pathogenic bacteria to coordinately regulate gene expression to maximize survival within or outside of a host. Here we show that Bordetella species regulate virulence factor expression in response to carbon dioxide levels ...
Sara E Hester, Minghsun Lui, Tracy Nicholson, Daryl Nowacki, Eric T Harvill   +4 more
doaj   +1 more source

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. [PDF]

PLoS ONE, 2017
The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS.
Alex Rivera-Millot, Elodie Lesne, Luis Solans, Loic Coutte, Justine Bertrand-Michel, Philippe Froguel, Véronique Dhennin, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson   +10 more
doaj   +1 more source

Conquering the host: Bordetella spp. and Pseudomonas aeruginosa molecular regulators in lung infection

Frontiers in Microbiology, 2022
When bacteria sense cues from the host environment, stress responses are activated. Two component systems, sigma factors, small RNAs, ppGpp stringent response, and chaperones start coordinate the expression of virulence factors or immunomodulators to ...
Alina M. Holban, Alina M. Holban, Courtney M. Gregoire, Monica C. Gestal   +3 more
doaj   +1 more source

A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

mSystems, 2020
The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P).
Jakub Novák, David Jurnečka, Irena Linhartová, Jana Holubová, Ondřej Staněk, Daniel Štipl, Ana Dienstbier, Branislav Večerek, Nayara Azevedo, Jan Provazník, Vladimír Beneš, Peter Šebo   +11 more
doaj   +1 more source

Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response

Scientific Reports, 2023
Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart, Federico Sisti, Mónica C. Gestal, Julieta Fernández   +3 more
doaj   +1 more source

Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector. [PDF]

PLoS Biology, 2017
Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined.
Dawn L Taylor-Mulneix, Liron Bendor, Bodo Linz, Israel Rivera, Valerie E Ryman, Kalyan K Dewan, Shannon M Wagner, Emily F Wilson, Lindsay J Hilburger, Laura E Cuff, Christopher M West, Eric T Harvill   +11 more
doaj   +1 more source