Results 21 to 30 of about 8,047 (199)

Bordetella BcrH1 and BcrH2 Are Specific Chaperones for the Pore-Forming Complex. [PDF]

Microbiol Immunol
ABSTRACT Bordetella has a type III secretion system that secretes virulence proteins crucial to the establishment of infection. The genes encoding components of the Bordetella type III secretion system are located in the bsc region on the chromosome. This region includes the bcrH1 and bcrH2 genes, which respectively encode the proteins BcrH1 and BcrH2.
Kishino Y, Ogawa T, Sato H, Abe A, Kuwae A.   +4 more
europepmc   +2 more sources

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network. [PDF]

Trop Med Int Health
ABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Reva ON, Sifuna A, Orata F, Omolo C, Iramiot JS, Enright MC, Mutshembele A, Zhou J, Shivoga WA.   +8 more
europepmc   +2 more sources

Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response

Scientific Reports, 2023
Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart, Federico Sisti, Mónica C. Gestal, Julieta Fernández   +3 more
doaj   +1 more source

Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector. [PDF]

PLoS Biology, 2017
Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined.
Dawn L Taylor-Mulneix, Liron Bendor, Bodo Linz, Israel Rivera, Valerie E Ryman, Kalyan K Dewan, Shannon M Wagner, Emily F Wilson, Lindsay J Hilburger, Laura E Cuff, Christopher M West, Eric T Harvill   +11 more
doaj   +1 more source

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding. [PDF]

Protein Sci
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Penning S, Mitchell L, Hong Y, Cunliffe T, Subedi P, Wang G, Hor L, Totsika M, Paxman JJ, Heras B.   +9 more
europepmc   +2 more sources

Tn5-induced mutations affecting virulence factors of Bordetella pertussis [PDF]

Infection and Immunity, 1983
Transposon Tn5 was used to isolate mutants of Bordetella pertussis. Strains with Tn5 insertions were screened for loss of virulence-associated factors, including filamentous hemagglutinin, hemolysin, and pertussis toxin. Several mutants deficient for hemolysin production were obtained.
A A, Weiss, E L, Hewlett, G A, Myers, S, Falkow   +3 more
openaire   +2 more sources

BipA Is Associated with Preventing Autoagglutination and Promoting Biofilm Formation in Bordetella holmesii. [PDF]

PLoS ONE, 2016
Bordetella holmesii causes both invasive and respiratory diseases in humans. Although the number of cases of pertussis-like respiratory illnesses due to B. holmesii infection has increased in the last decade worldwide, little is known about the virulence
Yukihiro Hiramatsu, Momoko Saito, Nao Otsuka, Eri Suzuki, Mineo Watanabe, Keigo Shibayama, Kazunari Kamachi   +6 more
doaj   +1 more source

The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis

mBio, 2018
Bordetella pertussis, Bordetella bronchiseptica, and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ, and the reasons
Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi   +8 more
doaj   +1 more source

Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium [PDF]

Infection and Immunity, 1988
We examined Bordetella avium for virulence factors common to Bordetella pertussis, including pertussis toxin, filamentous hemagglutinin, adenylate cyclase, dermonecrotic toxin, and tracheal cytotoxin. B. avium produced a dermonecrotic toxin and a tracheal cytotoxin. The dermonecrotic toxin of B.
C R, Gentry-Weeks, B T, Cookson, W E, Goldman, R B, Rimler, S B, Porter, R, Curtiss   +5 more
openaire   +2 more sources

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen burkholderia pseudomallei K96243 [PDF]

, 2010
Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease ...
Wilkinson Paul A., Dowling, Andrea J., Matthew T G Holden, Richard W. Titball, Nicholas R. Waterfield, Paul A Wilkinson, Titball, Richard W., Quail, MA, Bentley Stephen D., Holden Matthew T. G., Richard W Titball, Bentley, SD, Julia Reger, Quail, Michael A., Waterfield Nicholas R., Stephen D. Bentley, Waterfield, NR, Andrea J Dowling, Stephen D Bentley, Wilkinson, Paul A., Bentley, Stephen D., Holden, Matthew T. G., ffrench-Constant, Richard H., ffrench-Constant Richard H., ffrench-Constant, Richard, Richard H. ffrench-Constant, Paul A. Wilkinson, Matthew T. G. Holden, Michael A. Quail, Michael A Quail, Waterfield, Nicholas R., Dowling Andrea J., Reger, J, Titball Richard W., Nicholas R Waterfield, Reger, Julia, Quail Michael A., Andrea J. Dowling, Andrea J. Dowling, Richard H Ffrench-Constant, Dowling, AJ, Holden, Matthew, Wilkinson, PA, Reger Julia   +43 more
core   +1 more source