Results 11 to 20 of about 7,870 (170)
Frontiers in Immunology, 2018 Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors
Elena Pinelli +2 more
exaly +3 more sources
Identification of a CO2 responsive regulon in Bordetella. [PDF]
PLoS ONE, 2012 Sensing the environment allows pathogenic bacteria to coordinately regulate gene expression to maximize survival within or outside of a host. Here we show that Bordetella species regulate virulence factor expression in response to carbon dioxide levels ...
Sara E Hester +4 more
doaj +1 more source
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. [PDF]
PLoS ONE, 2017 The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS.
Alex Rivera-Millot +10 more
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Frontiers in Microbiology, 2022 When bacteria sense cues from the host environment, stress responses are activated. Two component systems, sigma factors, small RNAs, ppGpp stringent response, and chaperones start coordinate the expression of virulence factors or immunomodulators to ...
Alina M. Holban +3 more
doaj +1 more source
Virulence factor secretion and translocation by Bordetella species [PDF]
Current Opinion in Microbiology, 2009 Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional ...
Ruchi, Shrivastava, Jeff F, Miller
openaire +2 more sources
mSystems, 2020 The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P).
Jakub Novák +11 more
doaj +1 more source
Scientific Reports, 2023 Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart +3 more
doaj +1 more source
The virulence factors ofBordetella pertussis: a matter of control [PDF]
FEMS Microbiology Reviews, 2001 Bordetella pertussis is the causative agent of whooping cough, a contagious childhood respiratory disease. Increasing public concern over the safety of whole-cell vaccines led to decreased immunisation rates and a subsequent increase in the incidence of the disease.
Smith, AM, Guzman, CA, Walker, MJ
openaire +5 more sources
Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector. [PDF]
PLoS Biology, 2017 Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined.
Dawn L Taylor-Mulneix +11 more
doaj +1 more source
Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of
mSystems, 2020 Bordetella pertussis regulates the production of its virulence factors by the two-component system BvgAS. In the virulence phase, BvgS phosphorylates BvgA, which then activates the transcription of virulence-activated genes (vags).
Loïc Coutte +7 more
doaj +3 more sources