Results 11 to 20 of about 8,047 (199)

The virulence factors ofBordetella pertussis: a matter of control [PDF]

FEMS Microbiology Reviews, 2001
Bordetella pertussis is the causative agent of whooping cough, a contagious childhood respiratory disease. Increasing public concern over the safety of whole-cell vaccines led to decreased immunisation rates and a subsequent increase in the incidence of the disease.
Smith, AM, Guzman, CA, Walker, MJ
openaire   +6 more sources

Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens [PDF]

BMC Genomics, 2012
Background The classical Bordetella subspecies are phylogenetically closely related, yet differ in some of the most interesting and important characteristics of pathogens, such as host range, virulence and persistence.
Park Jihye, Zhang Ying, Buboltz Anne M, Zhang Xuqing, Schuster Stephan C, Ahuja Umesh, Liu Minghsun, Miller Jeff F, Sebaihia Mohammed, Bentley Stephen D, Parkhill Julian, Harvill Eric T   +11 more
doaj   +3 more sources

The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae

BMC Genomics, 2008
Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella.
Schneiker-Bekel Susanne, Rückert Christian, Nakunst Diana, Mormann Sascha, Meyer Folker, Linke Burkhard, Link Stefanie, Larisch Christof, Khachane Amit N, Herrmann Stefanie, Gaigalat Lars, Ebensen Thomas, Choudhuri Jomuna V, Buhrmester Jens, Bartels Daniela, Lechner Melanie, Koebnik Ralf, Pieper Dietmar H, Martins dos Santos Vítor AP, Sebaihia Mohammed, Guzman Carlos A, Gross Roy, Schulze Kai, Vorhölter Frank-Jörg, Yevsa Tetyana, Engle Jacquelyn T, Goldman William E, Pühler Alfred, Göbel Ulf B, Goesmann Alexander, Blöcker Helmut, Kaiser Olaf, Martinez-Arias Rosa   +32 more
doaj   +3 more sources

Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of Bordetella pertussis

mSystems, 2020
Bordetella pertussis regulates the production of its virulence factors by the two-component system BvgAS. In the virulence phase, BvgS phosphorylates BvgA, which then activates the transcription of virulence-activated genes (vags).
Loïc Coutte, Rudy Antoine, Stephanie Slupek, Luis Solans, Julien Derop, Amelie Bonnefond, David Hot, Camille Locht   +7 more
doaj   +4 more sources

Bordetella pertussisVirulence Factors Affect Phagocytosis by Human Neutrophils [PDF]

Infection and Immunity, 2000
ABSTRACTThe interaction between human neutrophils and wild-typeBordetella pertussisor mutants expressing altered lipopolysaccharide or lacking virulence factors—pertussis toxin, adenylate cyclase toxin, dermonecrotic toxin, filamentous hemagglutinin (FHA), pertactin, or BrkA—was examined.
C L, Weingart, A A, Weiss
openaire   +3 more sources

Molecular evolution of the two-component system BvgAS involved in virulence regulation in Bordetella. [PDF]

PLoS ONE, 2009
The whooping cough agent Bordetella pertussis is closely related to Bordetella bronchiseptica, which is responsible for chronic respiratory infections in various mammals and is occasionally found in humans, and to Bordetella parapertussis, one lineage of
Julien Herrou, Anne-Sophie Debrie, Eve Willery, Geneviève Renauld-Mongénie, Camille Locht, Frits Mooi, Françoise Jacob-Dubuisson, Rudy Antoine   +7 more
doaj   +2 more sources

Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca_V3.1 as the Cell Surface Receptor

mBio, 2020
Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Takashi Nishida, Fuminori Sugihara, Yusuke Maeda, Yasuhiko Horiguchi   +13 more
doaj   +2 more sources

Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis.

Proceedings of the National Academy of Sciences, 1990
Regulation of the genes coding for virulence factors in Bordetella pertussis is controlled by the bvg locus, which encodes one putative sensory protein (BvgS) and one positive regulator of transcription (BvgA). We have studied the transcription of the bvg locus and found that this is controlled by a 350-base-pair DNA fragment, which contains five ...
Scarlato V., Prugnola A., Arico B., Rappuoli R.   +3 more
openaire   +5 more sources

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS. [PDF]

PLoS ONE, 2018
The whooping cough agent Bordetella pertussis coordinately regulates the expression of its virulence factors with the two-component system BvgAS. In laboratory conditions, specific chemical modulators are used to trigger phenotypic modulation of B ...
Elodie Lesne, Loic Coutte, Luis Solans, Stephanie Slupek, Anne-Sophie Debrie, Véronique Dhennin, Philippe Froguel, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson   +10 more
doaj   +3 more sources

A Case of Sepsis Caused by ST80 Multidrug-Resistant Enterococcus faecium With Concurrent Klebsiella pneumoniae Infection in a Dog. [PDF]

Vet Med Sci
An 8‐year‐old dog developed acute respiratory distress that progressed to sepsis and death. Multidrug‐resistant Enterococcus faecium ST80 was isolated from the liver and kidney, while Klebsiella pneumoniae was detected in the lung by PCR. Whole‐genome sequencing showed that the ST80 isolates were genetically identical, suggesting hematogenous spread ...
Seo HM, La TM, Seo YR, Lee DY, Han HJ, Hyeon JY.   +5 more
europepmc   +2 more sources