Results 11 to 20 of about 13,827 (215)

Bordetella BcrH1 and BcrH2 Are Specific Chaperones for the Pore-Forming Complex. [PDF]

Microbiol Immunol
ABSTRACT Bordetella has a type III secretion system that secretes virulence proteins crucial to the establishment of infection. The genes encoding components of the Bordetella type III secretion system are located in the bsc region on the chromosome. This region includes the bcrH1 and bcrH2 genes, which respectively encode the proteins BcrH1 and BcrH2.
Kishino Y, Ogawa T, Sato H, Abe A, Kuwae A.   +4 more
europepmc   +2 more sources

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network. [PDF]

Trop Med Int Health
ABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Reva ON, Sifuna A, Orata F, Omolo C, Iramiot JS, Enright MC, Mutshembele A, Zhou J, Shivoga WA.   +8 more
europepmc   +2 more sources

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding. [PDF]

Protein Sci
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Penning S, Mitchell L, Hong Y, Cunliffe T, Subedi P, Wang G, Hor L, Totsika M, Paxman JJ, Heras B.   +9 more
europepmc   +2 more sources

Virulence factor secretion and translocation by Bordetella species [PDF]

Current Opinion in Microbiology, 2009
Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional ...
Ruchi, Shrivastava, Jeff F, Miller
openaire   +2 more sources

The virulence factors ofBordetella pertussis: a matter of control [PDF]

FEMS Microbiology Reviews, 2001
Bordetella pertussis is the causative agent of whooping cough, a contagious childhood respiratory disease. Increasing public concern over the safety of whole-cell vaccines led to decreased immunisation rates and a subsequent increase in the incidence of the disease.
Smith, AM, Guzman, CA, Walker, MJ
openaire   +5 more sources

A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

mSystems, 2020
The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P).
Jakub Novák, David Jurnečka, Irena Linhartová, Jana Holubová, Ondřej Staněk, Daniel Štipl, Ana Dienstbier, Branislav Večerek, Nayara Azevedo, Jan Provazník, Vladimír Beneš, Peter Šebo   +11 more
doaj   +1 more source

Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response

Scientific Reports, 2023
Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart, Federico Sisti, Mónica C. Gestal, Julieta Fernández   +3 more
doaj   +1 more source

Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector. [PDF]

PLoS Biology, 2017
Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined.
Dawn L Taylor-Mulneix, Liron Bendor, Bodo Linz, Israel Rivera, Valerie E Ryman, Kalyan K Dewan, Shannon M Wagner, Emily F Wilson, Lindsay J Hilburger, Laura E Cuff, Christopher M West, Eric T Harvill   +11 more
doaj   +1 more source

Tn5-induced mutations affecting virulence factors of Bordetella pertussis [PDF]

Infection and Immunity, 1983
Transposon Tn5 was used to isolate mutants of Bordetella pertussis. Strains with Tn5 insertions were screened for loss of virulence-associated factors, including filamentous hemagglutinin, hemolysin, and pertussis toxin. Several mutants deficient for hemolysin production were obtained.
A A, Weiss, E L, Hewlett, G A, Myers, S, Falkow   +3 more
openaire   +2 more sources

Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of Bordetella pertussis

mSystems, 2020
Bordetella pertussis regulates the production of its virulence factors by the two-component system BvgAS. In the virulence phase, BvgS phosphorylates BvgA, which then activates the transcription of virulence-activated genes (vags).
Loïc Coutte, Rudy Antoine, Stephanie Slupek, Luis Solans, Julien Derop, Amelie Bonnefond, David Hot, Camille Locht   +7 more
doaj   +3 more sources