Results 41 to 50 of about 8,047 (199)

sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

BMC Microbiology, 2012
Background The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection.
Barchinger Sarah E, Zhang Xuqing, Hester Sara E, Rodriguez Maria E, Harvill Eric T, Ades Sarah E   +5 more
doaj   +1 more source

Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018

Emerging Infectious Diseases, 2022
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros, Albert Moreno-Mingorance, M. Teresa Martín-Gómez, Raquel Abad, Iván Bloise, Magda Campins, Alejandro González-Praetorius, M. Nieves Gutiérrez, Héctor Martín-González, Carmen Muñoz-Almagro, M. Ángeles Orellana, Manuela de Pablos, Josep Roca-Grande, Carlos Rodrigo, M. Elena Rodríguez, Sonia Uriona, M. José Vidal, Tomàs Pumarola, M. Nieves Larrosa, Juan José González-López   +19 more
doaj   +1 more source

Differential regulation of type III secretion and virulence genes inBordetella pertussisandBordetella bronchisepticaby a secreted anti-σ factor [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceBordetella bronchisepticaisolates from diverse hosts, including humans, display potent cytotoxicity against a broad range of mammalian cells, which is dependent on type III secretion system (T3SS) effector BteA. In contrast, neither laboratory nor clinical isolates ofBordetella pertussishave been observed to display T3SS-dependent ...
Ahuja, Umesh, Shokeen, Bhumika, Cheng, Ning, Cho, Yeonjoo, Blum, Charles, Coppola, Giovanni, Miller, Jeff F   +6 more
openaire   +4 more sources

Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

mBio, 2022
Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved.
Andrea M. DiVenere, Dzifa Amengor, Rui P. Silva, Jory A. Goldsmith, Jason S. McLellan, Jennifer A. Maynard   +5 more
doaj   +1 more source

Cyclic di-GMP Regulates the Type III Secretion System and Virulence in Bordetella bronchiseptica [PDF]

, 2022
The second messenger cyclic di-GMP (c-di-GMP) is a ubiquitous molecule in bacteria that regulates diverse phenotypes. Among them, motility and biofilm formation are the most studied. Furthermore, c-di-GMP has been suggested to regulate virulence factors,
Damron, F. Heath, Heath Damron, Fredrick, Damron, Fredrick Heath, Wong, Ting, Gutierrez, María de la Paz, Sisti, Federico, Sisti, Federico Bernardo, Fernández, Julieta, Wong, Ting Y.   +8 more
core   +1 more source

Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor

Frontiers in Immunology, 2018
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors
Elise S. Hovingh, Elise S. Hovingh, Steven de Maat, Alexandra P. M. Cloherty, Steven Johnson, Elena Pinelli, Coen Maas, Ilse Jongerius, Ilse Jongerius   +8 more
doaj   +1 more source

Bordetella pertussis outer membrane vesicles as virulence factor vehicles that influence bacterial interaction with macrophages

Pathogens and Disease, 2022
ABSTRACT Gram-negative pathogenic bacteria constitutively shed outer membrane vesicles (OMVs) which play a significant role in the host–pathogen interaction, eventually determining the outcome of the infection. We previously found that Bordetella pertussis, the etiological agent of whooping cough, survives the innate interaction with ...
Bruno Blancá, Jimena Alvarez Hayes, Kristin Surmann, Valdez Hugo, Christian Hentschker, Yanina Lamberti, Uwe Völker, María Eugenia Rodriguez   +7 more
openaire   +3 more sources

Virulence factors determine attachment and ingestion of nonopsonized and opsonized Bordetella pertussis by human monocytes [PDF]

Infection and Immunity, 1994
In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells attached to monocytes. Nonopsonized
Hazenbos, WLW, van den Berg, BM, van 't. Wout, JW, Mooi, FR, van Furth, R   +4 more
openaire   +3 more sources

Phosphate Limitation Modulates Vibrio Cholerae Outer Membrane Vesicle Formation, Composition and Toxicity

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Vibrio cholerae inhabits phosphorus‐poor aquatic environments and host intestine, where it expresses genes regulated by the PhoB/PhoR two‐component system in response to inorganic phosphate (Pi) limitation. Like other Gram‐negative bacteria, V.
Matheus Luchetta da Fonseca, Livia Carvalho Barbosa, Beatriz Ferreira de Carvalho Patricio, Wellington da Silva Ferreira, Carolina Neumann Keim, Cedric Delporte, Pierre van Antwerpen, Jean‐Marie Ruysschaert, Paulo Mascarello Bisch, Wanda Maria Almeida von Kruger   +9 more
wiley   +1 more source

Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract

, 2017
Significance Bordetella spp. includes Bordetella pertussis , the causal agent of whooping cough. The Bordetella virulence gene (BvgAS) two-component regulatory system (TCS)
Sara A. Marlatt, Steven M. Julio, Aaron J. Wilk, Andrew I. Perault, Scott Stibitz, M. Ashley Bone, Erich V. Scheller, Qing Chen, Peggy A. Cotter, Rebecca Anthouard   +9 more
core   +1 more source