Results 41 to 50 of about 7,870 (170)

Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

mBio, 2022
Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved.
Andrea M. DiVenere, Dzifa Amengor, Rui P. Silva, Jory A. Goldsmith, Jason S. McLellan, Jennifer A. Maynard   +5 more
doaj   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Bordetella pertussis outer membrane vesicles as virulence factor vehicles that influence bacterial interaction with macrophages

Pathogens and Disease, 2022
ABSTRACT Gram-negative pathogenic bacteria constitutively shed outer membrane vesicles (OMVs) which play a significant role in the host–pathogen interaction, eventually determining the outcome of the infection. We previously found that Bordetella pertussis, the etiological agent of whooping cough, survives the innate interaction with ...
Bruno Blancá, Jimena Alvarez Hayes, Kristin Surmann, Valdez Hugo, Christian Hentschker, Yanina Lamberti, Uwe Völker, María Eugenia Rodriguez   +7 more
openaire   +3 more sources

BopN is a Gatekeeper of the Bordetella Type III Secretion System

Microbiology Spectrum, 2023
The classical Bordetella species infect the respiratory tract of mammals. While B. bronchiseptica causes rather chronic respiratory infections in a variety of mammals, the human-adapted species B. pertussis and B.
Kevin Munoz Navarrete, Ladislav Bumba, Tatyana Prudnikova, Ivana Malcova, Tania Romero Allsop, Peter Sebo, Jana Kamanova   +6 more
doaj   +1 more source

Virulence factors determine attachment and ingestion of nonopsonized and opsonized Bordetella pertussis by human monocytes [PDF]

Infection and Immunity, 1994
In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells attached to monocytes. Nonopsonized
Hazenbos, WLW, van den Berg, BM, van 't. Wout, JW, Mooi, FR, van Furth, R   +4 more
openaire   +3 more sources

Phenotypic expression of the gene‐for‐gene interaction in plant pathogenic bacteria: An implication for resistance to bacterial diseases by plants

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Plant pathogenic bacteria cause massive losses in agriculture and damage to natural plant habitats. Bacterial pathogens not only reduce crop production, but they also reduce crop quality by releasing toxins into the environment. Pathogenic bacteria that invade plant tissues must overcome the plant's defense mechanisms. Plants possess an innate
Muluken Getahun, Zelalem Bekeko
wiley   +1 more source

Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor [PDF]

Emerging Microbes & Infections, 2018
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries represent up to 95% of recent clinical isolates.
Hovingh, ES, Mariman, R, Solans, L, Hijdra, D, Hamstra, HJ, Jongerius, I, van Gent, M, Mooi, F, Locht, C, Pinelli, E   +9 more
openaire   +4 more sources

Microbiological, Molecular Diagnosis and Antimicrobial Resistance of Bordetella bronchiseptica in the Equine Reproductive Tract in Brazil

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
First report of Bordetella bronchiseptica in the reproductive tract of Brazilian mares. Uterine lavage samples from mares with endometritis and infertility were positive by culture, PCR (237 bp flaA), sequencing and phylogenetic analysis. Isolates showed multidrug resistance, emphasizing the relevance of this pathogen in equine reproductive disorders ...
Samira Salim Mello Gallo, Maria de Lourdes Amaral Bernardino, Luiz Antonio Silveira da Motta Júnior, Francisco Carlos Rodrigues de Oliveira, Marcos Antonio Pessanha Barreto, Marcio Manhães Folly   +5 more
wiley   +1 more source

PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice

Toxins, 2021
Whooping cough is a severe, highly contagious disease of the human respiratory tract, caused by Bordetellapertussis. The pathogenicity requires several virulence factors, including pertussis toxin (PTX), a key component of current available vaccines ...
Julie Tomas, Yoon Koo, Dimitri Popoff, Vilma Arce-Gorvel, Sean Hanniffy, Jean-Pierre Gorvel, Cyrille Mionnet   +6 more
doaj   +1 more source

Phosphate Limitation Modulates Vibrio Cholerae Outer Membrane Vesicle Formation, Composition and Toxicity

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Vibrio cholerae inhabits phosphorus‐poor aquatic environments and host intestine, where it expresses genes regulated by the PhoB/PhoR two‐component system in response to inorganic phosphate (Pi) limitation. Like other Gram‐negative bacteria, V.
Matheus Luchetta da Fonseca, Livia Carvalho Barbosa, Beatriz Ferreira de Carvalho Patricio, Wellington da Silva Ferreira, Carolina Neumann Keim, Cedric Delporte, Pierre van Antwerpen, Jean‐Marie Ruysschaert, Paulo Mascarello Bisch, Wanda Maria Almeida von Kruger   +9 more
wiley   +1 more source