Results 41 to 50 of about 13,827 (215)

Novel Strategies to Inhibit Pertussis Toxin

Toxins, 2022
Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT).
Katharina Ernst
doaj   +1 more source

Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence [PDF]

, 2000
The phosphoglucomutase (PGM)-encoding gene of Bordetella bronchiseptica is required for lipopolysaccharide (LPS) biosynthesis. An insertion mutant of the wild-type B.
West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A., Walker, Mark J.   +5 more
core   +1 more source

Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca_V3.1 as the Cell Surface Receptor

mBio, 2020
Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Takashi Nishida, Fuminori Sugihara, Yusuke Maeda, Yasuhiko Horiguchi   +13 more
doaj   +1 more source

isolates in Finland: Serotype and fimbrial expression [PDF]

, 2008
Background Bordetella pertussis causes whooping cough or pertussis in humans. It produces several virulence factors, of which the fimbriae are considered adhesins and elicit immune responses in the host. B.
Eriikka Heikkinen, Dorothy K Xing, Rose-Marie Olander, Jukka Hytonen, Matti K Viljanen, Jussi Mertsola, Qiushui He   +6 more
core   +1 more source

RETRACTED: Melanin Produced by Bordetella parapertussis Confers a Survival Advantage to the Bacterium during Host Infection

mSphere, 2021
Bordetella parapertussis causes respiratory infection in humans, with a mild pertussis (whooping cough)-like disease. The organism produces a brown pigment, the nature and biological significance of which have not been elucidated.
Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Fuminori Sugihara, Yasuhiko Horiguchi   +4 more
doaj   +1 more source

Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella

mBio, 2016
The two-component system BvgAS controls the expression of the virulence regulon of Bordetella pertussis. BvgS is a prototype of bacterial sensor kinases with extracytoplasmic Venus flytrap perception domains.
E. Lesne, E.-M. Krammer, E. Dupre, C. Locht, M. F. Lensink, R. Antoine, F. Jacob-Dubuisson   +6 more
doaj   +1 more source

Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018

Emerging Infectious Diseases, 2022
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros, Albert Moreno-Mingorance, M. Teresa Martín-Gómez, Raquel Abad, Iván Bloise, Magda Campins, Alejandro González-Praetorius, M. Nieves Gutiérrez, Héctor Martín-González, Carmen Muñoz-Almagro, M. Ángeles Orellana, Manuela de Pablos, Josep Roca-Grande, Carlos Rodrigo, M. Elena Rodríguez, Sonia Uriona, M. José Vidal, Tomàs Pumarola, M. Nieves Larrosa, Juan José González-López   +19 more
doaj   +1 more source

Differential regulation of type III secretion and virulence genes inBordetella pertussisandBordetella bronchisepticaby a secreted anti-σ factor [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceBordetella bronchisepticaisolates from diverse hosts, including humans, display potent cytotoxicity against a broad range of mammalian cells, which is dependent on type III secretion system (T3SS) effector BteA. In contrast, neither laboratory nor clinical isolates ofBordetella pertussishave been observed to display T3SS-dependent ...
Ahuja, Umesh, Shokeen, Bhumika, Cheng, Ning, Cho, Yeonjoo, Blum, Charles, Coppola, Giovanni, Miller, Jeff F   +6 more
openaire   +4 more sources

sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

BMC Microbiology, 2012
Background The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection.
Barchinger Sarah E, Zhang Xuqing, Hester Sara E, Rodriguez Maria E, Harvill Eric T, Ades Sarah E   +5 more
doaj   +1 more source

Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

mBio, 2022
Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved.
Andrea M. DiVenere, Dzifa Amengor, Rui P. Silva, Jory A. Goldsmith, Jason S. McLellan, Jennifer A. Maynard   +5 more
doaj   +1 more source