Virulence Factors of Bordetella pertussis.
Nippon Saikingaku Zasshi, 1996 百日咳はワクチン接種の普及により日本では過去の病気となりつつあるが, 予防接種の行き渡らない国々では今なお猛威を奮っている小児の呼吸器伝染病で, 病因的にはジフテリアと同様, 毒素性疾患として理解し得る。最近では伝染源としての成人感染者が問題視され始めたが, 呼吸器感染症の常として根絶は殆ど不可能であり, 感染の予防, 治療に関する研究成果のみが百日咳の制圧を可能にする途である。本小文では, 百日咳菌の産生する病原因子のうち, 感染の第一段階である宿主細胞への菌の吸着に関与する接着因子 (繊維状赤血球凝集素, 線毛, パータクチン) および百日咳症の発現に関与する毒素類 (百日咳毒素, アデニレートシクラーゼ毒素, 気管上皮細胞毒素, 皮膚壊死毒素, 内毒素) の産生, 性状 ...
openaire +4 more sources
mSphere, 2019 Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory infections, many of which are characterized by coughing of the infected hosts.
Keiji Nakamura +7 more
doaj +1 more source
Fha Deficient Bordetella pertussis Isolates in Iran with 50 Years Whole Cell Pertussis Vaccination
Iranian Journal of Public Health, 2021 Background: Bordetella pertussis, a highly contagious respiratory. Notably, the resurgence of pertussis has recently been associated with the lacking production of vaccine virulence factors.
Samaneh Saedi +5 more
doaj +1 more source
From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network. [PDF]
Trop Med Int HealthABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Reva ON +8 more
europepmc +2 more sources
Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum [PDF]
, 2006 In many plant and animal bacterial pathogens, the Type III secretion system (TTSS) that directly translocates effector proteins into the eukaryotic host cells is essential for the development of disease.
Christian Boucher +8 more
core +2 more sources
Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS. [PDF]
PLoS ONE, 2018 The whooping cough agent Bordetella pertussis coordinately regulates the expression of its virulence factors with the two-component system BvgAS. In laboratory conditions, specific chemical modulators are used to trigger phenotypic modulation of B ...
Elodie Lesne +10 more
doaj +1 more source
Role of Antibodies against Bordetella pertussis Virulence Factors in Adherence of Bordetella pertussis and Bordetella parapertussis to Human Bronchial Epithelial cells [PDF]
Infection and Immunity, 1999 ABSTRACT Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers ...
van den Berg, BM +3 more
openaire +4 more sources
mBio, 2020 Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya +13 more
doaj +1 more source
Novel Strategies to Inhibit Pertussis Toxin
Toxins, 2022 Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT).
Katharina Ernst
doaj +1 more source
Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis [PDF]
, 2011 Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E. +21 more
core +1 more source