Results 31 to 40 of about 7,870 (170)

Fha Deficient Bordetella pertussis Isolates in Iran with 50 Years Whole Cell Pertussis Vaccination

Iranian Journal of Public Health, 2021
Background: Bordetella pertussis, a highly contagious respiratory. Notably, the resurgence of pertussis has recently been associated with the lacking production of vaccine virulence factors.
Samaneh Saedi, Azadeh Safarchi, Faranak Tayebzadeh Moghadam, Siamak Heidarzadeh, Vajihe Sadat Nikbin, Fereshteh Shahcheraghi   +5 more
doaj   +1 more source

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS. [PDF]

PLoS ONE, 2018
The whooping cough agent Bordetella pertussis coordinately regulates the expression of its virulence factors with the two-component system BvgAS. In laboratory conditions, specific chemical modulators are used to trigger phenotypic modulation of B ...
Elodie Lesne, Loic Coutte, Luis Solans, Stephanie Slupek, Anne-Sophie Debrie, Véronique Dhennin, Philippe Froguel, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson   +10 more
doaj   +1 more source

Role of Antibodies against Bordetella pertussis Virulence Factors in Adherence of Bordetella pertussis and Bordetella parapertussis to Human Bronchial Epithelial cells [PDF]

Infection and Immunity, 1999
ABSTRACT Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers ...
van den Berg, BM, Beekhuizen, H, Mooi, FR, van Furth, R   +3 more
openaire   +4 more sources

Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca_V3.1 as the Cell Surface Receptor

mBio, 2020
Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Takashi Nishida, Fuminori Sugihara, Yusuke Maeda, Yasuhiko Horiguchi   +13 more
doaj   +1 more source

Novel Strategies to Inhibit Pertussis Toxin

Toxins, 2022
Pertussis, also known as whooping cough, is a respiratory disease caused by infection with Bordetella pertussis, which releases several virulence factors, including the AB-type pertussis toxin (PT).
Katharina Ernst
doaj   +1 more source

Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella

mBio, 2016
The two-component system BvgAS controls the expression of the virulence regulon of Bordetella pertussis. BvgS is a prototype of bacterial sensor kinases with extracytoplasmic Venus flytrap perception domains.
E. Lesne, E.-M. Krammer, E. Dupre, C. Locht, M. F. Lensink, R. Antoine, F. Jacob-Dubuisson   +6 more
doaj   +1 more source

sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

BMC Microbiology, 2012
Background The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection.
Barchinger Sarah E, Zhang Xuqing, Hester Sara E, Rodriguez Maria E, Harvill Eric T, Ades Sarah E   +5 more
doaj   +1 more source

RETRACTED: Melanin Produced by Bordetella parapertussis Confers a Survival Advantage to the Bacterium during Host Infection

mSphere, 2021
Bordetella parapertussis causes respiratory infection in humans, with a mild pertussis (whooping cough)-like disease. The organism produces a brown pigment, the nature and biological significance of which have not been elucidated.
Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Fuminori Sugihara, Yasuhiko Horiguchi   +4 more
doaj   +1 more source

Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018

Emerging Infectious Diseases, 2022
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros, Albert Moreno-Mingorance, M. Teresa Martín-Gómez, Raquel Abad, Iván Bloise, Magda Campins, Alejandro González-Praetorius, M. Nieves Gutiérrez, Héctor Martín-González, Carmen Muñoz-Almagro, M. Ángeles Orellana, Manuela de Pablos, Josep Roca-Grande, Carlos Rodrigo, M. Elena Rodríguez, Sonia Uriona, M. José Vidal, Tomàs Pumarola, M. Nieves Larrosa, Juan José González-López   +19 more
doaj   +1 more source

Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Bordetella bronchiseptica isolates from diverse hosts, including humans, display potent cytotoxicity against a broad range of mammalian cells, which is dependent on type III secretion system (T3SS) effector BteA. In contrast, neither laboratory nor clinical isolates of
Ahuja, Umesh, Shokeen, Bhumika, Cheng, Ning, Cho, Yeonjoo, Blum, Charles, Coppola, Giovanni, Miller, Jeff F   +6 more
openaire   +4 more sources