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The evolution of pertactin expression in Belgian circulating B. pertussis strains, pre- and post-COVID-19 [PDF]

open access: yesMicrobiology Spectrum
Prior to the COVID-19 pandemic, Bordetella pertussis strains not producing pertactin were globally increasing, especially in countries using the acellular pertussis vaccine. Subsequently, during the pandemic, global pertussis incidence dropped to extreme
Helena Martini   +6 more
doaj   +2 more sources

Bbvac: A Live Vaccine Candidate That Provides Long-Lasting Anamnestic and Th17-Mediated Immunity against the Three Classical Bordetella spp.

open access: yesMSphere, 2022
Acute pathogens such as Bordetella pertussis can cause severe disease but are ultimately cleared by the immune response. This has led to the accepted paradigm that convalescent immunity is optimal and therefore broadly accepted as the “gold standard ...
Cartelle M   +2 more
exaly   +3 more sources

Bordetella Adenylate Cyclase-Hemolysin Toxins

open access: yesToxins, 2017
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica.
Guiso Nicole
exaly   +3 more sources

Comparison of Bordetella species identification among differing rt-PCR assays in the United States

open access: yesMicrobiology Spectrum
In the United States, the general laboratory method for diagnosing pertussis, caused by Bordetella pertussis, is real-time PCR (rt-PCR) targeting insertion sequence 481 (IS481).
Margaret Williams, Matthew Cole
exaly   +3 more sources

Emergence of Bordetella holmesii–Associated Pertussis-Like Illness, Northern India, 2019–2023 [PDF]

open access: yesEmerging Infectious Diseases
We investigated Bordetella holmesii and Bordetella pertussis in 935 suspected pertussis cases in northern India (2019–2023) using PCR and serology. B. holmesii showed increased prevalence in pertussis cases, particularly in older children, highlighting ...
Nishant Shekhar   +12 more
doaj   +2 more sources

Immunobiological Properties of Biofilms of Bacteria of the Genus Bordetella

open access: yesЭпидемиология и вакцинопрофилактика, 2021
Relevance. Whooping cough remains a pressing public health problem worldwide, including in countries with high vaccination rates. One of the probable causes of the ongoing epidemic process of pertussis infection is B.
E. M. Zaitsev   +3 more
doaj   +1 more source

Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

open access: yesVirulence, 2021
Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS
Jesús Pérez-Ortega   +7 more
doaj   +1 more source

Rarely Encountered Gram-Negative Rods and Lung Transplant Recipients: A Narrative Review

open access: yesMicroorganisms, 2023
The respiratory tract of lung transplant recipients (LTR) is likely to be colonized with non-fermentative Gram-negative rods. As a consequence of the improvements in molecular sequencing and taxonomy, an increasing number of bacterial species have been ...
Eric Farfour   +5 more
doaj   +1 more source

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

open access: yesVirulence, 2021
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica.
Thomas Belcher   +4 more
doaj   +1 more source

Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation in Bordetella Biology and Virulence

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
The Bordetella genus is divided into two groups: classical and non-classical. Bordetella pertussis, Bordetella bronchiseptica and Bordetella parapertussis are known as classical bordetellae, a group of important human pathogens causing whooping cough or ...
Laurence Don Wai Luu   +4 more
doaj   +1 more source

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