Results 51 to 60 of about 32,826 (199)

CONSTRUCTION OF RECOMBINANT ATTENUATED BORDETELLA PERTUSSIS BACTERIA OF PTXP3 GENOTYPE

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. The construction of recombinant attenuated Bordetella pertussis bacteria of ptxP3 genotype and its genetic and biological stability characteristics. Materials and methods.
E. G. Semin, L. N. Sinyashina, A. Yu. Medkova, G. I. Karataev   +3 more
doaj   +1 more source

Small mutations in Bordetella pertussis are associated with selective sweeps. [PDF]

PLoS ONE, 2012
Bordetella pertussis is the causative agent of pertussis, a highly contagious disease of the human respiratory tract. Despite high vaccination coverage, pertussis has resurged and has become one of the most prevalent vaccine-preventable diseases in ...
Marjolein van Gent, Marieke J Bart, Han G J van der Heide, Kees J Heuvelman, Frits R Mooi   +4 more
doaj   +1 more source

Development of a qualitative assay for screening of Bordetella pertussis isolates for pertussis toxin production.

, 2017
Bordetella pertussis infection has been increasing in the US, with reported cases reaching over 50,000 in 2012, a number last observed in the 1950s. Concurrently, B. pertussis lacking the pertactin protein, one of the immunogens included in the acellular
Hong Ju, Pertussis Working Group, Irina Gates, M Lucia Tondella, Lucia Pawloski, Marina DuVall   +5 more
core   +1 more source

Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis

, 2021
Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection.
Peter Sebo, Aapo Knuutila, Radim Osicka, Alex-Mikael Barkoff, Qiushui He, Jussi Mertsola   +5 more
core   +1 more source

Changes in genetic diversity of the Bordetella pertussis population in Serbia between 1953 and 2011 [PDF]

Archives of Biological Sciences, 2014
Mass vaccination has significantly reduced the incidence of pertussis, however, the disease is re-emerging, even in some countries with high vaccination coverage. In Serbia, whole cell pertussis vaccine was introduced in 1957. To monitor changes
Plješa Tatjana, He Qiushui, Dakić Gordana, Vignjević-Krastavčević Mirjana, Miković Nevenka, Ćirković Ivana   +5 more
doaj   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source

Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

EBioMedicine, 2021
Background: Pertussis can lead to serious disease and even death in infants. Older adults are more vulnerable to complications as well. In high-income countries, acellular pertussis vaccines are used for priming vaccination.
Pauline Versteegen, Marta Valente Pinto, Alex M. Barkoff, Pieter G.M. van Gageldonk, dr. Jan van de Kassteele, dr. Marlies A. van Houten, prof. Elisabeth A.M. Sanders, prof. Ronald de Groot, dr. Dimitri A. Diavatopoulos, dr. Sagida Bibi, dr. Raakel Luoto, prof. Qiushui He, dr. Anne-Marie Buisman, dr. Dominic F. Kelly, prof. Jussi Mertsola, dr. Guy A.M. Berbers   +15 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates

Toxins, 2017
Bordetella pertussis and Bordetella parapertussis are the causal agents of whooping cough in humans. They produce diverse virulence factors, including adenylate cyclase-hemolysin (AC-Hly), a secreted toxin of the repeat in toxins (RTX) family with ...
Valérie Bouchez, Thibaut Douché, Mélody Dazas, Sophie Delaplane, Mariette Matondo, Julia Chamot-Rooke, Nicole Guiso   +6 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source