Bordetella Adenylate Cyclase-Hemolysin Toxins [PDF]
Toxins, 2017 Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica.
Nicole Guiso
exaly +6 more sources
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes [PDF]
Toxins, 2021 The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. This toxin primarily targets innate immunity to facilitate bacterial colonization of the respiratory tract ...
Daniel Ladant
doaj +3 more sources
Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation [PDF]
Frontiers in Immunology, 2020 Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight
Jawid Nazir Ahmad, Peter Sebo
doaj +5 more sources
An Introduction to the Toxins Special Issue on the Adenylate Cyclase Toxin [PDF]
Toxins, 2018 n ...
Alexandre Chenal
doaj +6 more sources
Phospholipase A activity of adenylate cyclase toxin? [PDF]
Proc Natl Acad Sci U S A, 2018 Gonzalez-Bullon et al. (1) detected a phospholipase A (PLA) activity in the preparations of adenylate cyclase (AC) toxin (ACT) purified from recombinant Escherichia coli . The authors conclude that the PLA activity is intrinsic to the toxin protein and facilitates translocation of its AC enzyme domain across the target cell membrane.
Masin J, Osicka R, Bumba L, Sebo P.
europepmc +4 more sources
The Minimal Folding Motif of the Repeat-in-Toxin Domain of Adenylate Cyclase Toxin. [PDF]
LangmuirThe bacterial adenylate cyclase toxin (CyaA) is the key virulence factor of the whooping cough-causing agent Bordetella pertussis. The folding of its repeats-in-toxin (RTX) domain is critical to CyaA's toxin activity and virulence. The RTX domain contains five RTX blocks (RTX-i to RTX-v), and its folding follows a strict vectorial, series folding ...
Chen G, Wang H, Straus SK, Li H.
europepmc +4 more sources
Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis [PDF]
Diagnostics, 2021 Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection.
Aapo Knuutila +5 more
doaj +2 more sources
Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes [PDF]
Toxins, 2020 The Gram-negative bacterium Bordetella pertussis is the cause of whooping cough. One of its pathogenicity factors is the adenylate cyclase toxin (CyaA) secreted by a Type I export system.
Oliver Knapp, Roland Benz
doaj +2 more sources
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin [PDF]
Toxins, 2018 Adenylate cyclase toxin (ACT, CyaA) is one of the important virulence factors secreted by the whooping cough bacterium Bordetella pertussis, and it is essential for the colonization of the human respiratory tract by this bacterium.
David González-Bullón +2 more
doaj +2 more sources
Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines [PDF]
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
doaj +2 more sources