Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation [PDF]
Frontiers in Immunology, 2020 Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight
Jawid Nazir Ahmad, Peter Sebo
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Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes [PDF]
Toxins, 2017 Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Helena Ostolaza +4 more
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An Introduction to the Toxins Special Issue on the Adenylate Cyclase Toxin [PDF]
Toxins, 2018 n ...
Alexandre Chenal
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Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes [PDF]
Toxins, 2021 The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. This toxin primarily targets innate immunity to facilitate bacterial colonization of the respiratory tract ...
Daniel Ladant
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Bordetella Adenylate Cyclase-Hemolysin Toxins [PDF]
Toxins, 2017 Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica.
Nicole Guiso
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Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin [PDF]
BMC Neuroscience, 2007 Background Several investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system. By producing deficits in function these toxin conjugates have yielded valuable information about the role ...
Perez Federico M +5 more
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Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis [PDF]
Diagnostics, 2021 Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection.
Aapo Knuutila +5 more
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Phospholipase A activity of adenylate cyclase toxin? [PDF]
Proc Natl Acad Sci U S A, 2018 Gonzalez-Bullon et al. (1) detected a phospholipase A (PLA) activity in the preparations of adenylate cyclase (AC) toxin (ACT) purified from recombinant Escherichia coli . The authors conclude that the PLA activity is intrinsic to the toxin protein and facilitates translocation of its AC enzyme domain across the target cell membrane.
Masin J, Osicka R, Bumba L, Sebo P.
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Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes [PDF]
Toxins, 2020 The Gram-negative bacterium Bordetella pertussis is the cause of whooping cough. One of its pathogenicity factors is the adenylate cyclase toxin (CyaA) secreted by a Type I export system.
Oliver Knapp, Roland Benz
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Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines [PDF]
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
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