Results 41 to 50 of about 175,144 (193)
PLoS Pathogens, 2010 Bordetella adenylate cyclase toxin (CyaA) binds the alpha(M)beta(2) integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP.
Ladislav Bumba +3 more
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In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity
Toxins, 2021 One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines.
Marieke Esther Hoonakker
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Reconstitution of cholera toxin-activated adenylate cyclase. [PDF]
Proceedings of the National Academy of Sciences, 1978 Reconstitution of adenylate cyclase activity responsive to stimulation by guanylyl-5'imidodiphosphate or NaF may be achieved by mixing dilute Lubrol 12A9-solubilized extracts of wild-type S49 membranes with membranes of an adenylate cyclase-deficient variant.
G L, Johnson, H R, Kaslow, H R, Bourne
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Hemolytic activity of adenylate cyclase toxin fromBordetella pertussis [PDF]
FEBS Letters, 1991 Adenylate cyclase (AC) toxin fromB. pertussis enters eukaryotic cells where it produces supraphysiologie levels of cAMP. Purification of AC toxin activity [(1989) J. Biol. Chem. 264, 19279] results in increasing potency of hemolytic activity and electroelution of the 216‐kDA holotoxin yields a single protein with AC enzymatic, toxin and hemolytic ...
Ehrmann, Ingrid E. +4 more
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Toxins, 2018 The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis.
Ladislav Bumba +4 more
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PLoS Pathogens, 2012 Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities.
Radovan Fiser +13 more
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Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines
Expert Review of Vaccines, 2014 The adenylate cyclase toxin-hemolysin (ACT, AC-Hly or CyaA) is a key virulence factor of Bordetella pertussis. It targets bactericidal activities of phagocytes, such as oxidative burst and complement- or antibody-mediated opsonophagocytic killing of bacteria.
Peter, Sebo, Radim, Osicka, Jiri, Masin
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Toxins, 2022 Various bacterial pathogens are producing toxins that target the cyclic Nucleotide Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization.
Marilyne Davi +4 more
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Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation
Advanced Science, EarlyView.Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi +9 more
wiley +1 more source
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
PLoS ONE, 2008 BackgroundAnthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling
Andrea Puhar +4 more
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