Results 41 to 50 of about 23,918 (199)

A Simple Luminescent Adenylate-Cyclase Functional Assay for Evaluation of Bacillus anthracis Edema Factor Activity

Toxins, 2016
Edema Factor (EF), the toxic sub-unit of the Bacillus anthracis Edema Toxin (ET) is a calmodulin-dependent adenylate cyclase whose detrimental activity in the infected host results in severe edema. EF is therefore a major virulence factor of B. anthracis.
Ma’ayan Israeli, Shahar Rotem, Uri Elia, Erez Bar-Haim, Ofer Cohen, Theodor Chitlaru   +5 more
doaj   +1 more source

The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis

mBio, 2018
Bordetella pertussis, Bordetella bronchiseptica, and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ, and the reasons
Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi   +8 more
doaj   +1 more source

P2Y12 receptor modulation of ADP‐evoked intracellular Ca2+ signalling in THP‐1 human monocytic cells [PDF]

, 2018
Background and purpose: The Gi‐coupled, ADP‐activated P2Y12 receptor is well characterised as playing a key role in platelet activation via crosstalk with P2Y1 in ADP‐evoked intracellular Ca2+ response.
Alexander, Alexander, Aungraheeta, Baqi, Ben Addi, Brinson, Campwala, Cattaneo, Communi, Communi, Curtis, Czerniecki, Dorsam, Erb, Giezen, Harding, Hardy, Husted, Jin, Kronlage, Mahaut-Smith, Mamedova, Mattana, Myers, Nylander, Sivaramakrishnan, Suplat, West, Zhang, Ziegler-Heitbrock   +29 more
core   +1 more source

Bordetella Adenylate Cyclase Toxin Can Bind Ganglioside GM1

BIO, 2011
Adenylate cyclase toxin (CyaA) is produced by Bordetella pertussis, the causative agent of whooping cough. CyaA specifically binds to the heavily Nglycosylated β2 integrin receptor CD11b/CD18 on its main cellular target myeloid phagocytic cells.
Lucyna Mrówczyńska, Małgorzata Bobrowska-Hägerstrand, Christer Lindqvist, Henry Hägerstrand   +3 more
openaire   +1 more source

Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. [PDF]

, 2013
Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. While
Buck, Jochen, Darszon, Alberto, de la Vega Beltran, José L., Escoffier, Jessica, Haddad, Douglas, Krapf, Dario, Levin, Lonny R., Mager, Jesse, Navarrete, Felipe, Salicioni, Ana M., Sánchez Cárdenas, Claudia, Visconti, Pablo E., Wertheimer Hermitte, Eva Victoria   +12 more
core   +1 more source

The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core   +1 more source

The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.

PLoS Pathogens, 2009
The adjuvanticity of bacterial adenylate cyclase toxins has been ascribed to their capacity, largely mediated by cAMP, to modulate APC activation, resulting in the expression of Th2-driving cytokines.
Silvia Rossi Paccani, Marisa Benagiano, Nagaja Capitani, Irene Zornetta, Daniel Ladant, Cesare Montecucco, Mario M D'Elios, Cosima T Baldari   +7 more
doaj   +1 more source

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Toxins, 2021
One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines.
Marieke Esther Hoonakker
doaj   +1 more source

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat [PDF]

, 2015
In the absence of an ability to absorb fluid by cellular uptake mechanisms, fluid movement in vivo from the perfused rat intestine is absorptive when the diastolic blood pressure is normal or very low but is secretory when blood pressure falls below ...
Lucas, Michael, Morrison, James
core   +1 more source

Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps.

PLoS Pathogens, 2010
Bordetella adenylate cyclase toxin (CyaA) binds the alpha(M)beta(2) integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP.
Ladislav Bumba, Jiri Masin, Radovan Fiser, Peter Sebo   +3 more
doaj   +1 more source