Results 31 to 40 of about 175,144 (193)
Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum [PDF]
, 1990 cAMP binds to surface receptors of Dictyostelium discoideum cells, transducing the signal to adenylate cyclase, guanylate cyclase and to chemotaxis.
Haastert, Peter J.M. van, +3 more
core +2 more sources
Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro [PDF]
, 2003 The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine ...
Dufès, Christine +4 more
core +4 more sources
Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]
, 2006 Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R. +15 more
core +1 more source
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin
BMC Neuroscience, 2007 Background Several investigators have coupled toxins to neuropeptides for the purpose of lesioning specific neurons in the central nervous system. By producing deficits in function these toxin conjugates have yielded valuable information about the role ...
Perez Federico M +5 more
doaj +1 more source
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin [PDF]
Infection and Immunity, 1988 Bordetella pertussis and Bacillus anthracis produce extracytoplasmic adenylate cyclase toxins (AC toxins) with shared features including activation by calmodulin and the ability to enter target cells and catalyze intracellular cyclic AMP (cAMP) production from host ATP.
V M, Gordon, S H, Leppla, E L, Hewlett
openaire +2 more sources
Renal action of cholera toxin: II. Effects on adenylate cyclase-cyclic AMP system [PDF]
, 1975 Renal action of cholera toxin: II. Effects on adenylate cyclase-cyclic AMP system. The effects of cholera toxin (CT) on the adenylate cyclase-adenosine 3′,5′-cyclic monophosphate (cAMP) system(s) in renal cortex were examined using the isolated renal ...
Massry, Shaul G. +2 more
core +1 more source
Toxins, 2016 Edema Factor (EF), the toxic sub-unit of the Bacillus anthracis Edema Toxin (ET) is a calmodulin-dependent adenylate cyclase whose detrimental activity in the infected host results in severe edema. EF is therefore a major virulence factor of B. anthracis.
Ma’ayan Israeli +5 more
doaj +1 more source
Mechanism of activation of adenylate cyclase by cholera toxin. [PDF]
Proceedings of the National Academy of Sciences, 1975 Cholera toxin (choleragen) can stimulate adenylate cyclase [EC 4.6.1.1; ATP pyrophosphate-lyase (cyclizing)] activity in whole particulate fractions or purified plasma membranes of homogenates of isolated fat cells provided special precautions are taken to stabilize the enzyme during the required preincubation period. As observed with intact cells, the
N, Sahyoun, P, Cuatrecasas
openaire +2 more sources
mBio, 2018 Bordetella pertussis, Bordetella bronchiseptica, and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ, and the reasons
Aya Fukui-Miyazaki +8 more
doaj +1 more source
PLoS Pathogens, 2009 The adjuvanticity of bacterial adenylate cyclase toxins has been ascribed to their capacity, largely mediated by cAMP, to modulate APC activation, resulting in the expression of Th2-driving cytokines.
Silvia Rossi Paccani +7 more
doaj +1 more source