Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes [PDF]
Toxins, 2017 Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host.
Jakub Novak +7 more
doaj +4 more sources
Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Numerous bacterial toxins can cross cell membranes, penetrating the cytosol of their target cells, but to do so exploits cellular endocytosis or intracellular sorting machineries. Bordetella pertussis adenylate cyclase toxin (ACT) delivers its catalytic domain ...
González-Bullón D +3 more
europepmc +6 more sources
Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity. [PDF]
PLoS ONE, 2011 Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active.
César Martín +3 more
doaj +3 more sources
Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain. [PDF]
PLoS ONE, 2013 Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract.
Kepa B Uribe +3 more
doaj +2 more sources
Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages [PDF]
mBioBordetella pertussis infects human upper airways and deploys an array of immunosuppressive virulence factors, among which the adenylate cyclase toxin (CyaA) plays a prominent role in disarming host phagocytes.
Jawid Nazir Ahmad +5 more
doaj +2 more sources
Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species [PDF]
mBioBordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber +5 more
doaj +2 more sources
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy [PDF]
Toxins, 2018 The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping cough. CyaA is able to invade eukaryotic cells where, upon activation by endogenous calmodulin, it synthesizes massive ...
Alexandre Chenal, Daniel Ladant
doaj +2 more sources
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes [PDF]
Toxins, 2017 Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Helena Ostolaza +4 more
doaj +2 more sources
Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size [PDF]
Biomolecules, 2019 RTX (Repeats in ToXin) pore-forming toxins constitute an expanding family of exoproteins secreted by many Gram-negative bacteria and involved in infectious diseases caused by said pathogens.
David González-Bullón +6 more
doaj +2 more sources
mBio, 2019 Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid ...
Jawid Nazir Ahmad +6 more
doaj +2 more sources