Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes [PDF]
Toxins, 2017 Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host.
Jakub Novak +7 more
doaj +4 more sources
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin [PDF]
Toxins, 2018 Adenylate cyclase toxin (ACT, CyaA) is one of the important virulence factors secreted by the whooping cough bacterium Bordetella pertussis, and it is essential for the colonization of the human respiratory tract by this bacterium.
David González-Bullón +2 more
doaj +2 more sources
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins [PDF]
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
doaj +5 more sources
Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages [PDF]
mBioBordetella pertussis infects human upper airways and deploys an array of immunosuppressive virulence factors, among which the adenylate cyclase toxin (CyaA) plays a prominent role in disarming host phagocytes.
Jawid Nazir Ahmad +5 more
doaj +2 more sources
Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species [PDF]
mBioBordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber +5 more
doaj +2 more sources
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy [PDF]
Toxins, 2018 The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping cough. CyaA is able to invade eukaryotic cells where, upon activation by endogenous calmodulin, it synthesizes massive ...
Alexandre Chenal, Daniel Ladant
doaj +2 more sources
Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Numerous bacterial toxins can cross cell membranes, penetrating the cytosol of their target cells, but to do so exploits cellular endocytosis or intracellular sorting machineries. Bordetella pertussis adenylate cyclase toxin (ACT) delivers its catalytic domain directly across the cell membrane
González-Bullón D +3 more
europepmc +4 more sources
Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size [PDF]
Biomolecules, 2019 RTX (Repeats in ToXin) pore-forming toxins constitute an expanding family of exoproteins secreted by many Gram-negative bacteria and involved in infectious diseases caused by said pathogens.
David González-Bullón +6 more
doaj +2 more sources
mBio, 2019 Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid ...
Jawid Nazir Ahmad +6 more
doaj +2 more sources
Bordetella filamentous hemagglutinin and adenylate cyclase toxin interactions on the bacterial surface are consistent with FhaB-mediated delivery of ACT to phagocytic cells [PDF]
mBioBordetella species that cause respiratory infections in mammals include B. pertussis, which causes human whooping cough, and B. bronchiseptica, which infects nearly all mammals.
Zachary M. Nash +3 more
doaj +2 more sources