Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain [PDF]
Toxins, 2018 The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis.
Ladislav Bumba +4 more
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cAMP signaling of Bordetella adenylate cyclase toxin blocks M-CSF triggered upregulation of iron acquisition receptors on differentiating CD14+ monocytes [PDF]
mSphereBordetella pertussis infects the upper airways of humans and disarms host defense by the potent immuno-subversive activities of its pertussis (PT) and adenylate cyclase (CyaA) toxins.
Jawid Nazir Ahmad, Peter Sebo
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Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells. [PDF]
Sci Rep, 2015 AbstractBordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium has been detected both in vitro and in vivo inside phagocytic and non-phagocytic cells.
Martín C +8 more
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Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation. [PDF]
PLoS Biology, 2018 Dissecting how bacterial pathogens escape immune destruction and cause respiratory infections in humans is a work in progress. One tactic employed by microbes is to use bacterial adenylate cyclase toxins (ACTs) to disarm immune cells and disrupt cellular
Natosha L Finley
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The adenylate cyclase-mediated signaling pathway required for regulating siderophore and toxin biosynthesis and pathogenicity in Alternaria alternata [PDF]
Frontiers in Fungal BiologyThe role of cyclic AMP–protein kinase A (PKA) signaling in siderophore-mediated iron uptake and its connection to virulence remains poorly understood in phytopathogenic fungi. Genetic studies demonstrate that the A.
Kai-Chu Huang +7 more
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Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis [PDF]
ToxinsPertussis toxin (PTx) is a major virulence factor of Bordetella pertussis and an AB5-type exotoxin that disrupts host signaling. Its enzymatic A subunit ADP-ribosylates the α-subunit of inhibitory G proteins (Gαi), preventing them from mediating receptor-
Qing Tang +3 more
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Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity. [PDF]
PLoS ONE, 2011 Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active.
César Martín +3 more
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Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain. [PDF]
PLoS ONE, 2013 Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract.
Kepa B Uribe +3 more
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Nature Communications, 2022 The authors use optical tweezers to show that the folding of repeats-in-toxin (RTX) block-iv in adenylate cyclase is templated by the folded RTX block-v. The findings suggest a possible mechanism for transmitting the folding signal in the RTX domain.
Han Wang, Guojun Chen, Hongbin Li
doaj +1 more source
Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines [PDF]
Expert Review of Vaccines, 2014 The adenylate cyclase toxin-hemolysin (ACT, AC-Hly or CyaA) is a key virulence factor of Bordetella pertussis. It targets bactericidal activities of phagocytes, such as oxidative burst and complement- or antibody-mediated opsonophagocytic killing of bacteria.
Peter, Sebo, Radim, Osicka, Jiri, Masin
openaire +3 more sources