Bordetella filamentous hemagglutinin and adenylate cyclase toxin interactions on the bacterial surface are consistent with FhaB-mediated delivery of ACT to phagocytic cells [PDF]
mBioBordetella species that cause respiratory infections in mammals include B. pertussis, which causes human whooping cough, and B. bronchiseptica, which infects nearly all mammals.
Zachary M. Nash +3 more
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cAMP signaling of Bordetella adenylate cyclase toxin blocks M-CSF triggered upregulation of iron acquisition receptors on differentiating CD14+ monocytes [PDF]
mSphereBordetella pertussis infects the upper airways of humans and disarms host defense by the potent immuno-subversive activities of its pertussis (PT) and adenylate cyclase (CyaA) toxins.
Jawid Nazir Ahmad, Peter Sebo
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Bordetella Adenylate Cyclase Toxin Can Bind Ganglioside GM1
BIO, 2011 Adenylate cyclase toxin (CyaA) is produced by Bordetella pertussis, the causative agent of whooping cough. CyaA specifically binds to the heavily Nglycosylated β2 integrin receptor CD11b/CD18 on its main cellular target myeloid phagocytic cells.
Lucyna Mrówczyńska +3 more
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Regulation of brain adenylate cyclase by calmodulin.
, 1988 The roles of Ca$\sp{2+}$ and cAMP are central to stimulus-response coupling mechanisms in cells. Hence, interactions between these two second messengers may be important for the coordinate regulation of the intracellular mechanisms responsible for the ...
Harrison, Jeffrey Keith
core +6 more sources
Nature Communications, 2022 The authors use optical tweezers to show that the folding of repeats-in-toxin (RTX) block-iv in adenylate cyclase is templated by the folded RTX block-v. The findings suggest a possible mechanism for transmitting the folding signal in the RTX domain.
Han Wang, Guojun Chen, Hongbin Li
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Anthrax edema factor toxicity is strongly mediated by the N-end rule. [PDF]
PLoS ONE, 2013 Anthrax edema factor (EF) is a calmodulin-dependent adenylate cyclase that converts adenosine triphosphate (ATP) into 3'-5'-cyclic adenosine monophosphate (cAMP), contributing to the establishment of Bacillus anthracis infections and the resulting ...
Clinton E Leysath +5 more
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Correction: The adenylate cyclase-mediated signaling pathway required for regulating siderophore and toxin biosynthesis and pathogenicity in Alternaria alternata [PDF]
Frontiers in Fungal BiologyKai-Chu Huang +7 more
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Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin. [PDF]
PLoS ONE, 2018 Several bacterial pathogens produce nucleotidyl cyclase toxins to manipulate eukaryotic host cells. Inside host cells they are activated by endogenous cofactors to produce high levels of cyclic nucleotides (cNMPs).
Dorothée Raoux-Barbot +9 more
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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]
, 2009 The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core +1 more source
mBio, 2020 Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya +13 more
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