Altered response of adenylate cyclase to parathyroid hormone during compensatory renal growth [PDF]
, 1989 Altered response of adenylate cyclase to parathyroid hormone during compensatory renal growth. The loss of renal mass is associated with functional adaptations in the remaining nephrons to maintain homeostasis.
Milanes, Carmen L. +5 more
core +1 more source
PLoS Pathogens, 2012 Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities.
Radovan Fiser +13 more
doaj +1 more source
Toxins, 2022 Various bacterial pathogens are producing toxins that target the cyclic Nucleotide Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization.
Marilyne Davi +4 more
doaj +1 more source
Constitutive P2Y2 receptor activity regulates basal lipolysis in human adipocytes [PDF]
, 2018 White adipocytes are key regulators of metabolic homeostasis, which release stored energy as free fatty acids via lipolysis. Adipocytes possess both basal and stimulated lipolytic capacity, but limited information exists regarding the molecular ...
Ahmadian +62 more
core +1 more source
Bordetellaadenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme [PDF]
Pathogens and Disease, 2015 The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) is a key virulence factor of the whooping cough agent Bordetella pertussis. CyaA targets myeloid phagocytes expressing the complement receptor 3 (CR3, known as αMβ2 integrin CD11b/CD18 or Mac-1) and translocates by a poorly understood mechanism directly across the cytoplasmic membrane into ...
Mašín, J. (Jiří) +3 more
openaire +3 more sources
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin [PDF]
Infection and Immunity, 1988 Bordetella pertussis and Bacillus anthracis produce extracytoplasmic adenylate cyclase toxins (AC toxins) with shared features including activation by calmodulin and the ability to enter target cells and catalyze intracellular cyclic AMP (cAMP) production from host ATP.
V M, Gordon, S H, Leppla, E L, Hewlett
openaire +2 more sources
Somatostatin analogs: Clinical application in relation to human somatostatin receptor subtypes [PDF]
, 1995 Correlates of protection (CoPs) against the highly contagious respiratory disease whooping cough, caused by Bordetella pertussis, remain elusive. Characterizing the antibody response to this pathogen is essential towards identifying potential CoPs. Here,
Hofland, L.J. (Leo) +2 more
core +6 more sources
Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
Advanced Science, EarlyView.This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley +1 more source
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
PLoS ONE, 2008 BackgroundAnthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling
Andrea Puhar +4 more
doaj +1 more source
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]
, 1979 Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM +3 more
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