Results 71 to 80 of about 175,144 (193)

Role of the segment 400-500 in biological activity of Bordetella pertussis adenylate cyclase toxin [PDF]

, 2017
The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in virulence of the whooping cough agent Bordetella pertussis. It translocates an AC enzyme into cytosol of CD11b+ phagocytes and subverts their bactericidal functions by unregulated ...
Suková, Anna
core  

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei, Seyed Shahram Miraghaee, Faegheh Farhadi, Abolfazl Akbarzadeh, Fatemeh Yarmohammadi   +4 more
wiley   +1 more source

Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells [PDF]

Pathogens and Disease, 2015
The adenylate cyclase toxin (ACT) of Bordetella pertussis internalizes its catalytic domain into target cells. ACT can function as a tool for delivering foreign protein antigen moieties into immune effector cells to induce a cytotoxic T lymphocyte response.
Masaaki, Iwaki, Toshifumi, Konda
openaire   +2 more sources

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells [PDF]

, 1992
Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells. Although several cytokines have been demonstrated to exert pleiotropic responses, there is little information on cytokine regulation of renal tubular epithelial cell function.
Anderson, Robert J., Breckon, Ruth, Ruth Breckon, Robert J. Anderson   +3 more
core   +1 more source

The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro

Toxins, 2019
The adenylate cyclase (CyaA) toxin produced in Bordetella pertussis is the causative agent of whooping cough. CyaA exhibits the remarkable capacity to translocate its N-terminal adenyl cyclase domain (ACD) directly across the plasma membrane into the ...
Alexis Voegele, Mirko Sadi, Dorothée Raoux-Barbot, Thibaut Douché, Mariette Matondo, Daniel Ladant, Alexandre Chenal   +6 more
doaj   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

Adenylate cyclase activity of ν-ras-k transformed rat epithelial thyroid cells [PDF]

, 1988
The regulation of adenylate cyclase has been analyzed in normal rat thyroid cells as well as in the same cells transformed by the ν-ras-k oncogene. In both cell types the adenylate cyclase complex consists of the two GTP-binding proteins, Gi and Gs, as ...
Kohn, Leonard D., Gennaro Schettini, Eduardo Consiglio, Giulia Colletta, Schettini, Gennaro, Cirafici, Anna Maria, Consiglio, Eduardo, Leonard D. Kohn, Daniela Corda, Colletta, Giulia, Anna Maria Cirafici, Corda, Daniela   +11 more
core   +1 more source

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source